Cited by 317Estrogen and related hormone effectsMenopause: Health Impacts and TreatmentsPhytoestrogen effects and research

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Comparison of pharmacodynamic properties of various estrogen formulations

Mashchak, C.Ann, Lobo, Rogerio A., Dozono-Takano, Ryoko, Eggena, Peter, Nakamura, Robert M., Brenner, Paul F., Mishell, Daniel R.·1982·American Journal of Obstetrics and Gynecology

DOI 10.1016/0002-9378(82)90218-6

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Abstract

A group of 23 healthy postmenopausal women received one or more 2-week courses of daily administration of the following estrogen preparations: piperazine estrone sulfate (Ogen), 0.3, 0.625, 1.25, 2.5, and 5.0 mg; micronized estradiol (Estrace), 1, 2, and 10 mg; conjugated estrogens (Premarin), 0.3, 0.625, 1.25, and 2.5 mg; ethinyl estradiol (Estinyl), 10 and 20 micrograms; and diethylstilbestrol, 0.1 and 0.5 mg. Each dosage of each formulation was ingested by three women. In those women who received more than one dosage, each course was separated by a drug-free interval of at least 4 weeks. Pretreatment and posttreatment levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), corticosteroid-binding globulin-binding capacity, sex hormone-binding globulin-binding capacity, angiotensinogen, estrone, and estradiol were determined. The relative potency of these five estrogen formulations was determined by parallel line analysis for each of these responses, except LH. On a weight basis, piperazine estrone sulfate and micronized estradiol were equipotent for all responses. Conjugated estrogens suppressed FSH in a fashion equipotent to that of the other nonsynthetic estrogens; however, for all three hepatic parameters, the response was exaggerated twofold to threefold. The synthetic estrogens, diethylstilbestrol and ethinyl estradiol, were relatively more potent on a weight basis for every response and produced the most marked response (fourfold to eighteenfold in excess of their FSH suppression) for the hepatic parameters.

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Authors: Mashchak, C. A., Lobo, R. A., Dozono-Takano, R., Eggena, P., Nakamura, R. M., Brenner, P. F., & Mishell, D. R.
Affiliations: University of Southern California (US)
Corresponding author: Mishell, Daniel R.
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 1982-11
Volume: 144
Issue: 5
Pages: 511-518
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/0002-9378(82)90218-6
OpenAlex: W1593764750
Cited by: 316
References: 10
Citations by year: 2026: 2 · 2025: 8 · 2024: 5 · 2023: 5 · 2022: 11 · 2021: 8 · 2020: 7 · 2019: 1 · 2018: 5 · 2017: 10 · 2016: 4 · 2015: 13 · 2014: 3 · 2013: 10 · 2012: 15
FWCI: 2.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
Keywords: pharmacodynamics, postmenopausal women, micronized estradiol, conjugated estrogens, ethinyl estradiol, diethylstilbestrol, luteinizing hormone, sex hormone-binding globulin, corticosteroid-binding globulin, angiotensinogen, estrone, estradiol, relative potency, synthetic estrogens
MeSH terms: Angiotensinogen, Diethylstilbestrol, Estradiol, Estrogens, Conjugated (USP), Estrogens, Estrone, Ethinyl Estradiol, Female, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Menopause, Sex Hormone-Binding Globulin, Transcortin

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Comparison of pharmacodynamic properties of various estrogen formulations

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