Cited by 134Menopause: Health Impacts and TreatmentsAnesthesia and Sedative AgentsEstrogen and related hormone effects

Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites

Arafat, ElSayed S., Hargrove, Joel T., Maxson, Wayne S., Desiderio, Dominic M., Wentz, Anne Colston, Andersen, Richard N.·1988·American Journal of Obstetrics and Gynecology

Abstract

Progesterone and its metabolites were measured in serum extracts by radioimmunoassay and gas chromatography-mass spectrometry, respectively, after ingestion of micronized progesterone by eight postmenopausal women. One subject received 400 mg of micronized progesterone orally that induced a hypnotic state that lasted for approximately 2 hours. Blood samples were drawn periodically from all subjects for measurement of progesterone and its metabolites in serum. Levels of serum progesterone and its metabolites increased significantly from baseline values and reached a peak between 2 and 6 hours after oral progesterone administration. Significant quantities of five compounds (progesterone, 5 alpha-pregnan-3 alpha-ol-20-one, 5 beta-pregnan-3 alpha-ol-20-one, 5 beta-pregnan-3 alpha,20 beta-diol, and 5 beta-pregnan-3 alpha-ol-11,20-dione) that have been reported to possess anesthetic qualities were identified. The sedative and hypnotic effects of oral administration of progesterone may be mediated through those compounds.

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Crossref · 10.1016/0002-9378(88)90448-6

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Authors
Arafat, E. S., Hargrove, J. T., Maxson, W. S., Desiderio, D. M., Wentz, A. C., & Andersen, R. N.
Affiliations
  • Rust College (US)
  • Vanderbilt University Medical Center (US)
  • University of Tennessee Health Science Center (US)
Corresponding author
Hargrove, Joel T.
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
1988-11
Volume
159
Issue
5
Pages
1203-1209
ISSN
0002-9378 (ISSN-L)
OpenAlex
W2042977357
Cited by
134
References
22
Citations by year
2026: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 2 · 2015: 1 · 2013: 4 · 2012: 2
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2s14rr002866-04)
  • National Institute of General Medical Sciences (GM26666)
  • National Center for Research Resources (5S14RR02866)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
micronized progesterone, sedative effects, hypnotic effects, progesterone metabolites, postmenopausal women, oral administration, serum progesterone, 5alpha-pregnan-3alpha-ol-20-one, sleep induction
MeSH terms
Administration, Oral, Blood Chemical Analysis, Chromatography, Gas, Dose-Response Relationship, Drug, Female, Humans, Hypnotics and Sedatives, Middle Aged, Powders, Progesterone, Mass Spectrometry, Time Factors

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