Circadian myometrial and endocrine rhythms in the pregnant rhesus macaque: Effects of constant light and timed melatonin infusion
Abstract
Six chronically catheterized rhesus macaques maintained on a 12-hour-light/dark cycle (lights on from 7 AM to 7 PM) showed a nocturnal uterine activity rhythm with peak contractile events between 9 and 11 PM (p less than 0.05). In blood samples collected at 3-hour intervals over a 24-hour period, we determined that plasma melatonin and progesterone concentrations were elevated at night whereas estradiol, estrone, and cortisol reached peak concentrations in the early morning (p less than 0.05). Lights were then left on for the remainder of the study. After 12 days in constant light, daily rhythms in uterine activity and plasma steroid levels were relatively unchanged, whereas melatonin concentrations were suppressed. Animals then received a timed infusion of melatonin (0.2 mg/kg/hr each day from 7 PM to 6 AM daily until delivery). The nocturnal uterine activity rhythm and the rhythms in plasma steroid concentrations were maintained. We conclude that the 24-hour patterns in maternal uterine activity and plasma steroid hormone levels are circadian rhythms generated by an endogenous biologic clock and do not appear to be driven by the pattern of melatonin in circulation.
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Exposing pregnant non-human primates to constant light suppresses the emergence of melatonin and body temperature rhythms in their offspring following birth, suggesting that maternal rhythms are important for the early brain development of fetal circadian systems.
“Exposing pregnant NHPs to constant light suppresses the emergence of melatonin and body temperature rhythms in their offspring following birth42–44, suggesting that maternal rhythms are important for the early brain development of fetal circadian systems45.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [44]
Cites
Oxford reviews of reproductive biology
(1981) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(81)93042-5 · Cited by 751 · see citing works
Neuroendocrine Basis of Seasonal Reproduction
Karsch, F. J., Bittman, E. L., Foster, D. L., Goodman, R. L., Legan, S. J., & Robinson, J. E. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-571140-1.50010-4 · Cited by 602 · see citing works
Winfree, A. T. (1983) · Mathematical Biosciences · doi:10.1016/0025-5564(83)90095-0 · Cited by 541 · see citing works
Primate Behavior. Developments in Field and Laboratory Research, 4
(1977) · Journal of Human Evolution · doi:10.1016/s0047-2484(77)80021-3 · Cited by 327 · see citing works
Mammalian pineal melatonin: A clock for all seasons
Bartness, T. J., & Goldman, B. D. (1989) · Cellular and Molecular Life Sciences · doi:10.1007/bf01953051 · Cited by 312 · see citing works
Estrogens in Fetal and Maternal Plasma of the Rhesus Monkey
Resko, J. A., PLOEM, J. G., & Stadelman, H. L. (1975) · Endocrinology · doi:10.1210/endo-97-2-425 · Cited by 237 · see citing works
Resko, J. A., Ellinwood, W. E., Pasztor, L. M., & Buhl, A. E. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-50-5-900 · Cited by 207 · see citing works
Resko, J. A., Norman, R. L., NISWENDER, G. D., & Spies, H. G. (1974) · Endocrinology · doi:10.1210/endo-94-1-128 · Cited by 202 · see citing works
Regulation of Myometrial Adrenoreceptors and Adrenergic Response by Sex Steroids
Roberts, J. M., Insel, P. A., & Goldfien, A. (1981) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13904-7 · Cited by 121 · see citing works
Goldman, B. D., Darrow, J. M., & Yogev, L. (1984) · Endocrinology · doi:10.1210/endo-114-6-2074 · Cited by 110 · see citing works
Yellon, S. M., & Longo, L. D. (1988) · Biology of Reproduction · doi:10.1095/biolreprod39.5.1093 · Cited by 103 · see citing works
Self-citationTaylor, N. F., Martin, M. C., Nathanielsz, P. W., et al. (1983) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(83)90803-7 · Cited by 100 · see citing works
PREGNANCY AND DELIVERY BEHAVIOR IN THE SQUIRREL MONKEY (SAIMIRI SCIUREUS) AND OTHER PRIMATES
Bowden, D. M., Winter, P., & Ploog, D. W. (1967) · Folia Primatologica · doi:10.1159/000161936 · Cited by 99 · see citing works
Hess, D. L., Spies, H. G., & Hendrickx, A. G. (1981) · Biology of Reproduction · doi:10.1095/biolreprod24.3.609 · Cited by 93 · see citing works
Self-citationParturition in Primates: Behavior Related to Birth
Brandt, E. M., & Mitchell, G. (1971) · Elsevier eBooks · doi:10.1016/b978-0-12-534002-1.50010-9 · Cited by 77 · see citing works
Circadian hormonal interactions among the mother, fetus, and amniotic fluid
Walsh, S. W., Ducsay, C. A., & Novy, M. J. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(84)90679-3 · Cited by 76 · see citing works
Self-citationThe Endocrine Control of the Fetus
Künzel, W. W. F., & Jensen, A. (1988) · Springer eBooks · doi:10.1007/978-3-642-72975-1 · Cited by 65 · see citing works
Circadian patterns and dexamethasone-induced changes in uterine activity in pregnant rhesus monkeys
Ducsay, C. A., Cook, M. J., Walsh, S. W., et al. (1983) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(83)90305-8 · Cited by 62 · see citing works
Self-citationHsu, H.-W., Figueroa, J. P., Barbera, M., et al. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90543-7 · Cited by 47 · see citing works
Endocrine and Morphological Maturation of the Fetal and Neonatal Adrenal Cortex in Baboons*
Ducsay, C. A., Hess, D. L., McClellan, M. C., & Novy, M. J. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-2-385 · Cited by 47 · see citing works
Self-citationDiurnal variations in maternal and fetal steroids in pregnant rhesus monkeys.
Challis, Socol, M. L., Murata, Y., et al. (1980) · PubMed · Cited by 47 · see citing works
Photoperiod Regulation of Uterine Activity and Melatonin Rhythms in the Pregnant Rhesus Macaque1
Ducsay, C. A., & Yellon, S. M. (1991) · Biology of Reproduction · doi:10.1095/biolreprod44.6.967 · Cited by 41 · see citing works
Self-citationFigueroa, J. P., Honnebier, M. B. O. M., Jenkins, S. L., et al. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)91217-z · Cited by 39 · see citing works
Biorhythms of the primate uterus (Macaca mulatta) during labor and delivery
Harbert, G. M., & Spisso, K. R. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90089-7 · Cited by 38 · see citing works
Ca, D., Mj, C., & Novy, M. J. (1988) · PubMed · Cited by 32 · see citing works
Foster, D. L., Ebling, F. J. P., Claypool, L. E., et al. (1989) · Biology of Reproduction · doi:10.1095/biolreprod40.5.920 · Cited by 29 · see citing works
CHARACTERISTICS OF THE DAILY RHYTHM OF MENSTRUATION AND LABOR
Málek, J., Gleich, J., & Malý, V. (1962) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1962.tb30617.x · Cited by 29 · see citing works
The four direct regulatory factors of myometrial function
CSAPO, A. (1969) · Biblioteca Digital (Real Academia Nacional de Medicina) · Cited by 27 · see citing works
Neuroendocrine responsiveness to light during the neonatal period in the sheep
Ebling, F. J. P., Claypool, L. E., & Foster, D. L. (1988) · Journal of Endocrinology · doi:10.1677/joe.0.1190211 · Cited by 25 · see citing works
Circadian Uterine Activity in the Pregnant Rhesus Macaque: Do Prostaglandins Play a Role?1
Ducsay, C. A., & McNutt, C. M. (1989) · Biology of Reproduction · doi:10.1095/biolreprod40.5.988 · Cited by 22 · see citing works
Self-citationEstrone, 17β-Estradiol, and Cortisol in Serum of Peripartum Rhesus Monkeys*
Sholl, S. A., Robinson, J. A., & Wolf, R. C. (1979) · Endocrinology · doi:10.1210/endo-104-5-1274 · Cited by 22 · see citing works
A microcomputer program for real-time data acquisition in the perinatal physiology laboratory.
Ps, D., Ca, D., Rd, G., et al. (1989) · PubMed · Cited by 22 · see citing works
Biological Timekeeping During Pregnancy and the Role of Circadian Rhythms in Parturition
Longo, L. D., & Yellon, S. M. (1988) · Springer eBooks · doi:10.1007/978-3-642-72975-1_15 · Cited by 20 · see citing works
Self-citationChanging parturition time in monkeys (Macaca nemestrina) from night to day.
Gd, J., & Ra, B. (1967) · PubMed · Cited by 13 · see citing works
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Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
Circadian rhythms in the fetus
Serón-Ferré, M., Mendez, N., Abarzua-Catalan, L., Vilches, N., Valenzuela, F. J., Reynolds, H. E., Llanos, A. J., Rojas, A., Valenzuela, G. J., & Torres-Farfan, C. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.039 · Cited by 186 · see citing works
Self-citationMaternal melatonin selectively inhibits cortisol production in the primate fetal adrenal gland
Torres‐Farfan, C., Richter, H. G., Germain, A. M., Valenzuela, G. J., Campino, C., Rojas‐García, P., Forcelledo, M. L., Torrealba, F., & Serón‐Ferré, M. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.056465 · Cited by 85 · see citing works
Self-citationImpact of Chronodisruption during Primate Pregnancy on the Maternal and Newborn Temperature Rhythms
Serón-Ferré, M., Forcelledo, M. L., Torres-Farfan, C., Valenzuela, F. J., Rojas, A., Vergara, M., Rojas-Garcia, P. P., Recabarren, M. P., & Valenzuela, G. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057710 · Cited by 55 · see citing works
Self-citation
- Authors
- Matsumoto, T., Hess, D. L., Kaushal, K. M., Valenzuela, G. J., Yellon, S. M., & Ducsay, C. A.
- Affiliations
- Loma Linda University (US)
- Corresponding author
- Ducsay, Charles A.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1991-12
- Volume
- 165
- Issue
- 6
- Pages
- 1777-1784
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2016656607
- Cited by
- 39
- References
- 34
- Citations by year
- 2025: 2 · 2022: 1 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29hd022865-04)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 22865, HD 18185)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Keywords
- circadian rhythm, uterine contractility, melatonin, progesterone, estradiol, cortisol, endocrine rhythms, constant light, rhesus monkeys, pregnancy, biological clock, steroid secretion
- MeSH terms
- Animals, Circadian Rhythm, Estradiol, Estrogens, Estrone, Female, Hydrocortisone, Macaca mulatta, Melatonin, Pregnancy, Progesterone, Uterine Contraction
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