Impact of Chronodisruption during Primate Pregnancy on the Maternal and Newborn Temperature Rhythms
Open accessAbstract
Disruption of the maternal environment during pregnancy is a key contributor to offspring diseases that develop in adult life. To explore the impact of chronodisruption during pregnancy in primates, we exposed pregnant capuchin monkeys to constant light (eliminating the maternal melatonin rhythm) from the last third of gestation to term. Maternal temperature and activity circadian rhythms were assessed as well as the newborn temperature rhythm. Additionally we studied the effect of daily maternal melatonin replacement during pregnancy on these rhythms. Ten pregnant capuchin monkeys were exposed to constant light from 60% of gestation to term. Five received a daily oral dose of melatonin (250 µg kg/body weight) at 1800 h (LL+Mel) and the other five a placebo (LL). Six additional pregnant females were maintained in a 14∶10 light:dark cycles and their newborns were used as controls (LD). Rhythms were recorded 96 h before delivery in the mother and at 4-6 days of age in the newborn. Exposure to constant light had no effect on the maternal body temperature rhythm however it delayed the acrophase of the activity rhythm. Neither rhythm was affected by melatonin replacement. In contrast, maternal exposure to constant light affected the newborn body temperature rhythm. This rhythm was entrained in control newborns whereas LL newborns showed a random distribution of the acrophases over 24-h. In addition, mean temperature was decreased (34.0±0.6 vs 36.1±0.2°C, in LL and control, respectively P<0.05). Maternal melatonin replacement during pregnancy re-synchronized the acrophases and restored mean temperature to the values in control newborns. Our findings demonstrate that prenatal melatonin is a Zeitgeber for the newborn temperature rhythm and supports normal body temperature maintenance. Altogether these prenatal melatonin effects highlight the physiological importance of the maternal melatonin rhythm during pregnancy for the newborn primate.
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Exposing pregnant non-human primates to constant light suppresses the emergence of melatonin and body temperature rhythms in their offspring following birth, suggesting that maternal rhythms are important for the early brain development of fetal circadian systems.
“Exposing pregnant NHPs to constant light suppresses the emergence of melatonin and body temperature rhythms in their offspring following birth42–44, suggesting that maternal rhythms are important for the early brain development of fetal circadian systems45.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [43]
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Rhythms of life: circadian disruption and brain disorders across the lifespan
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- Authors
- Serón-Ferré, M., Forcelledo, M. L., Torres-Farfan, C., Valenzuela, F. J., Rojas, A., Vergara, M., Rojas-Garcia, P. P., Recabarren, M. P., & Valenzuela, G. J.
- Affiliations
- Pontificia Universidad Católica de Chile (CL)
- University of Chile (CL)
- Arrowhead Regional Medical Center (US)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-02-28
- Volume
- 8
- Issue
- 2
- Pages
- e57710
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3585206
- OpenAlex
- W1971099345
- Cited by
- 55
- References
- 38
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2021: 5 · 2020: 20 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 1
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian rhythm disruption, pregnancy, melatonin, circadian rhythm, body temperature rhythm, activity rhythms, continuous light exposure, capuchin monkeys, neonates, acrophase, zeitgebers, prenatal programming, circadian entrainment
- MeSH terms
- Animals, Animals, Newborn, Behavior, Animal, Cebus, Circadian Rhythm, Female, Light, Male, Melatonin, Mothers, Pregnancy, Pregnancy Trimester, Third, Temperature, Time Factors, Maternal Exposure
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