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Cited by 149Gestational Diabetes Research and ManagementBirth, Development, and HealthTrace Elements in Health

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Prevention of diabetes-associated embryopathy by overexpression of the free radical scavenger copper zinc superoxide dismutase in transgenic mouse embryos

Hagay, Zion J., Weiss, Yael, Zusman, Igor, Peled-Kamar, Mira, Reece, E.Albert, Eriksson, Ulf J., Groner, Yoram·1995·American Journal of Obstetrics and Gynecology
DOI 10.1016/0002-9378(95)91323-8
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Abstract

Objectives It has recently been suggested that oxygen free radicals are involved in the high incidence of fetal dysmorphogenesis that is associated with diabetic pregnancies. The purpose of the current investigation was to study the effect of copper zinc superoxide dismutase, a free radical scavenging enzyme, on the prevention of diabetes-associated embryopathy in mice. Study design Mice used in this study were either transgenic, bearing the human copper zinc superoxide dismutase gene, or nontransgenic controls. Diabetes was generated by streptozotocin administration on days 6 and 7 of gestation. Hyperglycemia developed on day 8 and was maintained through day 10 (critical period of organogenesis). On day 10 fetuses were examined for external anomalies, and their crown-rump lengths and deoxyribonucleic acid content were determined. Results Induction of maternal diabetes produced a significant reduction in mean crown-rump length of control embryos (4.48 +/- 0.7 mm vs 3.65 +/- 0.6 mm, p = 0.0001), whereas transgenic embryos were not affected (4.72 +/- 0.6 mm vs 4.45 +/- 0.8 mm, p > 0.05). After induction of diabetes fetal loss and malformation rates were significantly higher in control embryos (6.0% vs 23.8% and 8.4% vs 16.5%, respectively). Transgenic embryos were practically unaffected by diabetes and showed fetal loss and malformation rates of 5.9% and 4.4%, respectively, after induction of diabetes. Conclusions Elevated levels of copper zinc superoxide dismutase, a key enzyme in the metabolism of free oxygen radicals, elicit a protective effect against diabetes-associated embryopathy.

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Crossref · 10.1016/0002-9378(95)91323-8

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  1. Eriksson, 1993, Increased superoxide dismutase (SOD) activity in embryos of transgenic mice protects from the teratogenic effects of a diabetic environment, Diabetes, 42, 85A

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Metadata

Authors
Hagay, Z. J., Weiss, Y., Zusman, I., Peled-Kamar, M., Reece, E. A., Eriksson, U. J., & Groner, Y.
Affiliations
  • Kaplan Medical Center (IL)
  • Weizmann Institute of Science (IL)
  • Hebrew University of Jerusalem (IL)
  • Temple University (US)
  • Uppsala University (SE)
Corresponding author
Hagay, Zion J.
ORCID
Groner, Yoram
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
1995-10
Volume
173
Issue
4
Pages
1036-1041
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/0002-9378(95)91323-8
OpenAlex
W2050726467
Cited by
149
References
25
Citations by year
2024: 2 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 10
FWCI
10.69
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
copper-zinc superoxide dismutase, oxygen free radicals, transgenic embryos, maternal diabetes, streptozotocin-induced diabetes, fetal death, crown-rump length, organogenesis, antioxidant defense
MeSH terms
Congenital Abnormalities, Analysis of Variance, Animals, Diabetes Mellitus, Experimental, Embryo, Mammalian, Female, Humans, Mice, Transgenic, Pregnancy, Pregnancy in Diabetics, Superoxide Dismutase, Gene Expression, Chi-Square Distribution, Odds Ratio, Free Radical Scavengers, Mice

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