The histochemistry of drusen
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Drusen contain acute phase proteins, complement pathway components and inhibitors, apolipoproteins B and E, mucopolysaccarides, lipids, mannose, and sialic acid.
“Studies analyzing the composition of drusen have shown that drusen contain acute phase proteins (C-reactive protein, vitronectin, α-antichymotrypsin, amyloid P component, and fibrinogen), complement pathway components (C3, C5 and C5b-9 complex) and inhibitors (clusterin), apolipoproteins B and E, mucopolysaccarides, lipids, mannose, and sialic acid (Farkas et al., 1971; Mullins et al., 2000).”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Farkas et al., 1971
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- Authors
- Farkas, T. G., Sylvester, V., Archer, D., & Altona, M.
- Affiliations
- University of Chicago (US)
- ORCID
- Farkas, Tibor G.
- Venue
- American Journal of Ophthalmology
- Publisher
- Elsevier BV
- Published
- 1971-06
- Volume
- 71
- Issue
- 6
- Pages
- 1206-1215
- ISSN
- 0002-9394 (ISSN-L)
- OpenAlex
- W1980032656
- Cited by
- 112
- References
- 11
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- drusen, histology, retinal pigment epithelium, macular degeneration
- MeSH terms
- Cerebrosides, Choroid, Choroiditis, Eye Neoplasms, Gangliosides, Glycosaminoglycans, Histocytochemistry, Humans, Lipids, Melanoma, Membranes, Mucins, Neuraminic Acids, Polysaccharides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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