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The antioxidant action of ergothioneine
Abstract
Ergothioneine is a product of plant origin that accumulates in animal tissues. Its suggested ability to act as an antioxidant has been evaluated. Ergothioneine is a powerful scavenger of hydroxyl radicals (.OH) and an inhibitor of iron or copper ion-dependent generation of .OH from hydrogen peroxide (H2O2). It is also an inhibitor of copper ion-dependent oxidation of oxyhaemoglobin, and of arachidonic acid peroxidation promoted by mixtures of myoglobin (or haemoglobin) and H2O2. Ergothioneine is a powerful scavenger of hypochlorous acid, being able to protect alpha 1-antiproteinase against inactivation by this molecule. By contrast, it does not react rapidly with superoxide (O2-) or hydrogen peroxide (H2O2) and it does not inhibit microsomal lipid peroxidation in the presence of iron ions. Overall, our results show that ergothioneine at the concentrations present in vivo could act as an antioxidant.
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“Although the literature is somewhat scattered and heterogeneous, it seems clear that as well as hydroxyl radicals(228–232), ERG can also react with and detoxify, or prevent the formation of, singlet oxygen(233–242), ozone(243), superoxide(231,241,244–246), peroxide(32,124,247,248), hypochlorite(32,232,249) and peroxynitrite(224,231,250,251).”
From The biology of ergothioneine, an antioxidant nutraceutical (2020) · cites this paper as [228]
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Photoageing: mechanism, prevention and therapy
Yaar, M., & Gilchrest, B. A. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08108.x · Cited by 755
Intracellular Antioxidants: from Chemical to Biochemical Mechanisms
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Ulrich, K., & Jakob, U. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.035 · Cited by 574
Ergothioneine; antioxidant potential, physiological function and role in disease
Cheah, I. K., & Halliwell, B. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.09.017 · Cited by 514
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Metadata
- Authors
- Akanmu, D., Cecchini, R., Aruoma, O. I., & Halliwell, B.
- Affiliations
- University of London (GB)
- University of California Davis Medical Center (US)
- Corresponding author
- Halliwell, Barry
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 1991-07
- Volume
- 288
- Issue
- 1
- Pages
- 10-16
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2039684034
- Cited by
- 251
- References
- 51
- Citations by year
- 2026: 17 · 2025: 15 · 2024: 10 · 2023: 11 · 2022: 20 · 2021: 16 · 2020: 7 · 2019: 13 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 7 · 2014: 17 · 2013: 6 · 2012: 14
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- ergothioneine, antioxidant activity, hydroxyl radical scavenging, hydrogen peroxide, copper-catalyzed oxidation, iron-catalyzed oxidation, arachidonic acid peroxidation, myoglobin, hypochlorous acid, alpha-1-antiproteinase, superoxide, lipid peroxidation
- MeSH terms
- alpha 1-Antitrypsin, Animals, Antioxidants, Copper, Ergothioneine, Hemoglobins, Humans, Hydrogen Peroxide, Hydroxides, Myoglobin, Superoxides, Lipid Peroxidation, Hydroxyl Radical, In Vitro Techniques
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