The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Proteolysis of tau by calpain
Abstract
The calpain-induced proteolysis of tau associated with twice-cycled microtubules or from a total brain heat-stable fraction was studied. Twice-cycled microtubule tau was rapidly hydrolyzed by calpain. In contrast, tau purified from the total brain heat-stable fraction was very resistant to degradation by calpain. These results clearly demonstrate that there are at least 2 populations of tau in the brain based on calpain-sensitivity, a calpain-sensitive form that is associated with microtubules and a calpain-resistant form that may represent another population of tau in the brain.
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In the citing paper
“while calpain-2 cleaves tau at Arg230 [202–206].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [202]
In the citing paper
“Calpain-1 cleaves tau at Lys44, Arg230, Arg242, Gly323, and Gly326”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [202]
Citations
Cites
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
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Phosphorylation affects the ability of tau protein to promote microtubule assembly.
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Bancher, C., Brunner, C., Lassmann, H., Budka, H., Jellinger, K., Wiche, G., Seitelberger, F., Grundke-Iqbal, I., Iqbal, K., & Wisniewski, H. M. (1989) · Brain Research · doi:10.1016/0006-8993(89)91396-6 · Cited by 818
Microtubule-Associated Proteins: Their Potential Role In Determining Neuronal Morphology
Matus, A. I. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.000333 · Cited by 606
Microtubule-Associated Proteins
Olmsted, J. B. (1986) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.02.110186.002225 · Cited by 563
Phosphorylation determines two distinct species of tau in the central nervous system
Papasozomenos, S. C., & Binder, L. I. (1987) · Cell Motility · doi:10.1002/cm.970080303 · Cited by 420
Self-citationStructure of the Bovine Tau Gene: Alternatively Spliced Transcripts Generate a Protein Family
Himmler, A. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.4.1389 · Cited by 327
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Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain
Pant, H. C. (1988) · Biochemical Journal · doi:10.1042/bj2560665 · Cited by 238
Separation and characterization of microtubule proteins from calf brain
Berkowitz, S. A., Katagiri, J., Binder, H. K., & Williams, R. C. (1977) · Biochemistry · doi:10.1021/bi00644a035 · Cited by 200
Research works printed but not linked: 5
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- Wood, 1986, 83, 4040
- Grundke-Iqbal, 1986, 83, 4913
- Pontremoli, 1984, 81, 6714
- Towbin, 1979, 76, 4354
Cited by
Sorted by citations
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994
Roles of tau protein in health and disease
Guo, T., Noble, W., & Hanger, D. P. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1707-9 · Cited by 1,003
Role of tau protein in both physiological and pathological conditions
AVILA, J., LUCAS, J. J., PÉREZ, M., & HERNÁNDEZ, F. (2004) · Physiological Reviews · doi:10.1152/physrev.00024.2003 · Cited by 1,005
Cysteine Proteases and Their Inhibitors
Otto, H., & Schirmeister, T. (1997) · Chemical Reviews · doi:10.1021/cr950025u · Cited by 760
Cutting to the chase: calpain proteases in cell motility
Glading, A., Lauffenburger, D. A., & Wells, A. H. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02179-1 · Cited by 388
Metadata
- Authors
- Johnson, G. V. W., Jope, R. S., & Binder, L. I.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Johnson, Gail V.W.
- ORCID
- Johnson, Gail V.W.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1989-09
- Volume
- 163
- Issue
- 3
- Pages
- 1505-1511
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2026101249
- Cited by
- 161
- References
- 18
- Citations by year
- 2025: 2 · 2021: 1 · 2020: 4 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 8
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ag006569-13)
- National Institute on Aging (P01 AG06569)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Keywords
- tau protein, calpain, proteolysis, microtubules, tau isoforms
- MeSH terms
- Animals, Brain, Calpain, Cattle, Kinetics, Microtubule-Associated Proteins, Microtubules, Nerve Tissue Proteins, Immunoblotting, tau Proteins
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