Jope, Richard S.

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

Beurel, E., Grieco, S. F., & Jope, R. S. (2015) · Pharmacology & Therapeutics

Wnt/β-catenin signaling in development and cancerProtein Kinase Regulation and GTPase Signaling

Cited by 1,768

Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics

Jope, R. S., Yuskaitis, C. J., & Beurel, E. (2007) · Neurochemical Research

Wnt/β-catenin signaling in development and cancerProtein Kinase Regulation and GTPase Signaling

Cited by 774

In Vivo Regulation of Glycogen Synthase Kinase-3β (GSK3β) by Serotonergic Activity in Mouse Brain

Li, X., Zhu, W., Roh, M.-S., Friedman, A. B., Rosborough, K., & Jope, R. S. (2004) · Neuropsychopharmacology

Treatment of Major DepressionBipolar Disorder and Treatment

Cited by 300

Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

Li, X., & Jope, R. S. (2010) · Neuropsychopharmacology

Bipolar Disorder and TreatmentTreatment of Major Depression

Cited by 294

TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice

Cheng, Y., Desse, S., Martinez, A., Worthen, R. J., Jope, R. S., & Beurel, E. (2018) · Brain, Behavior, and Immunity

Tryptophan and brain disordersTreatment of Major Depression

Cited by 292

Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice

Beurel, E., Song, L., & Jope, R. S. (2011) · Molecular Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 288

Inflammatory T helper 17 cells promote depression-like behavior in mice

Beurel, E., Harrington, L. E., & Jope, R. S. (2013) · Biological Psychiatry

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 254

Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity

Yuskaitis, C. J., & Jope, R. S. (2009) · Cellular Signalling

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 240

Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances

Polter, A., Beurel, E., Yang, S., Garner, R., Song, L., Miller, C. A., Sweatt, J. D., McMahon, L., Bartolucci, A. A., Li, X., et al. (2010) · Neuropsychopharmacology

Bipolar Disorder and TreatmentTreatment of Major Depression

Cited by 225

Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior

Cheng, Y., Pardo, M., Armini, R. D. S., Martinez, A., Mouhsine, H., Zagury, J.-F., Jope, R. S., & Beurel, E. (2016) · Brain, Behavior, and Immunity

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 174

Proteolysis of tau by calpain

Johnson, G. V. W., Jope, R. S., & Binder, L. I. (1989) · Biochemical and Biophysical Research Communications

Calpain Protease Function and RegulationAlzheimer's disease research and treatments

Cited by 161

Elevated glycogen synthase kinase-3 activity in Fragile X mice: Key metabolic regulator with evidence for treatment potential

Min, W. W., Yuskaitis, C. J., Yan, Q., Sikorski, C., Chen, S., Jope, R. S., & Bauchwitz, R. P. (2009) · Neuropharmacology

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 146

Blocked Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3α/β Impairs In Vivo Neural Precursor Cell Proliferation

Eom, T.-Y., & Jope, R. S. (2009) · Biological Psychiatry

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 115

Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits

Beurel, E., & Jope, R. S. (2014) · Translational Psychiatry

Tryptophan and brain disordersSuicide and Self-Harm Studies

Cited by 92

Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells

Beurel, E., Yeh, W.-I., Michalek, S. M., Harrington, L. E., & Jope, R. S. (2011) · The Journal of Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 86

Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome.

Yuskaitis, C. J., Beurel, E., & Jope, R. S. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 79

Ketamine‐induced inhibition of glycogen synthase kinase‐3 contributes to the augmentation of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA) receptor signaling

Beurel, E., Grieco, S. F., Amadei, C., Downey, K., & Jope, R. S. (2016) · Bipolar Disorders

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 76

A pre-conditioning stress accelerates increases in mouse plasma inflammatory cytokines induced by stress

Cheng, Y., Jope, R. S., & Beurel, E. (2015) · BMC Neuroscience

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 70

Distinct characteristics of hippocampal pathogenic th17 cells in a mouse model of depression

Beurel, E., Lowell, J. A., & Jope, R. S. (2018) · Brain, Behavior, and Immunity

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 65

Oxidative Stress and Heat Shock Stimulate RGS2 Expression in 1321N1 Astrocytoma Cells

Zmijewski, J. W., Song, L., Harkins, L., Cobbs, C. S., & Jope, R. S. (2001) · Archives of Biochemistry and Biophysics

Redox biology and oxidative stressProtein Kinase Regulation and GTPase Signaling

Cited by 48