Stimulation of insulin secretion by transforming growth factor- β

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Transforming Growth Factor-β: Biological Function and Chemical Structure

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The TGF-β family of growth and differentiation factors

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Insulin secretion: Combined effects of phorbol ester and A23187

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Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

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TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation

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Transforming growth factor-β pathway: Role in pancreas development and pancreatic disease

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Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

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TGF-beta stimulates insulin secretion and blocks mitogenic response of pancreatic beta-cells to glucose

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Emerging roles for the TGFβ family in pancreatic β-cell homeostasis

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Th2 Cytokines Have a Partial, Direct Protective Effect on the Function and Survival of Isolated Human Islets Exposed to Combined Proinflammatory and Th1 Cytokines

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Role of polyamines in the regulation of proliferation and hormone production by insulin-secreting cells

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TGF-β signaling in pancreatic islet β cell development and function.

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Transforming growth factor β induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene‐1 in rat insulinoma cells

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SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity

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Growth factor control of pancreatic B cell hyperplasia

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Calcium as a second messenger of the action of transforming growth factor-β on insulin secretion

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Differential synthesis and action of TGFβ superfamily ligands in mouse and rat islets

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Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands

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Transforming Growth Factor β Is a Critical Regulator of Adult Human Islet Plasticity

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β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs

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The Role of the TGFβ Receptor Signaling Pathway in Adult Beta Cell Proliferation

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Triphenyl Phosphate Alters Methyltransferase Expression and Induces Genome-Wide Aberrant DNA Methylation in Zebrafish Larvae

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Correlation of glycemic regulation and endotrophin in patients with type 2 Diabetes; pilot study

Yoldemir, Ş. A., Arman, Y., Akarsu, M., Altun, Ö., Özcan, M., & Tükek, T. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-021-00628-5 · Cited by 12 · see citing works

The Role of TGF-β Signaling in β-Cell Dysfunction and Type 2 Diabetes: A Review

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Recombinant Human Transforming Growth Factor β Does Not Inhibit the Effects of Interleukin-1β on Pancreatic Islet Cells

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Analysis of the transcriptome and metabolome of pancreatic spheroids derived from human induced pluripotent stem cells and matured in an organ-on-a-chip

Essaouiba, A., Jellali, R., Poulain, S., Tokito, F., Gilard, F., Gakière, B., Kim, S. H., Legallais, C., Sakai, Y., & Leclerc, É. (2022) · Molecular Omics · doi:10.1039/d2mo00132b · Cited by 10 · see citing works

Bimodal effect of transforming growth factor-β on insulin secretion in MIN6 cells

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Peptide and Protein Hormones

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Suppression of MafA-dependent transcription by transforming growth factor-β signaling

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Effects of high dose retinoic acid on TGF-β2 expression during pancreatic organogenesis

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Molecular signaling in pancreatic ductal metaplasia: emerging biomarkers for detection and intervention of early pancreatic cancer

Li, X., He, J., & Xie, K. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00664-x · Cited by 6 · see citing works

Transforming Growth Factor-β-Mullerian Inhibiting Substance Family of Growth Regulators

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Autocrine/Paracrine Intermediates in Hormonal Action and Modulation of Cellular Responses to Hormones

Denef, C. (1998) · Comprehensive physiology · doi:10.1002/cphy.cp070118 · Cited by 5 · see citing works

Strategies to promote beta-cell replication and regeneration

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Transforming Growth Factor-& Mullerian Inhibiting Substance Fiannily of Growth Regulators

Liu, M. A., & Oliff, A. (1991)

Investigating the differentiation and functional maturation of stem cell-derived β cells

Velazco-Cruz, L. (2021) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/8q4b-x232

Effect of short-term intensive insulin pump therapy on serum endotrophin levels in patients with newly diagnosed type 2 diabetes

Li, Y., Gui, X., Weng, Y., Xun, L., Yu, W., Xiang, C., Qi, X., Wang, X., & Bai, F. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1658272

Autocrine/Paracrine Intermediates in Hormonal Action and Modulation of Cellular Responses to Hormones

Denef, C. (1997) · Comprehensive physiology · doi:10.1002/j.2040-4603.1997.tb01442.x

TGF-beta stimulates insulin secretion and blocks mitogenic response of pancreatic beta-cells to glucose

Sjöholm, Å., & Hellerström, C. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.260.5.c1046 · Cited by 65 · see citing works

Bimodal effect of transforming growth factor-β on insulin secretion in MIN6 cells

Sekine, N., Yamashita, N., Kojima, I., Miyazaki, J., & Ogata, E. (1994) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(94)90133-3 · Cited by 10 · see citing works

Tansforming growth factor-β regulates insulin gene expression in isolated rat islets

Ling, D. (2009)

Transforming growth factor β induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene‐1 in rat insulinoma cells

Sayo, Y., Hosokawa, H., Imachi, H., Murao, K., Sato, M., Wong, N. C. W., Ishida, T., & Takahara, J. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01080.x · Cited by 38 · see citing works

Transforming growth factor β (TGF-β) increases insulin-like factor I (IGF I) secretion in osteoblast-like cells

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