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Cited by 63Pancreatic function and diabetesDiabetes and associated disordersTGF-β signaling in diseases

Emerging roles for the TGFβ family in pancreatic β-cell homeostasis

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Brown, Melissa L., Schneyer, Alan L.·2010·Trends in Endocrinology & Metabolism
DOI 10.1016/j.tem.2010.02.008PMC PMC2897975
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Abstract

Loss of functional beta-cells is the primary cause of type 2 diabetes, so that there is an acute need to understand how beta-cell number and function are regulated in the adult under normal physiological conditions. Recent studies suggest that members of the transforming growth factor (TGF)-beta family regulate beta-cell function and glucose homeostasis. These factors are also likely to influence beta-cell proliferation and/or the incorporation of new beta-cells from progenitors in adults. Soluble TGFbeta antagonists also appear to have important roles in maintaining homeostasis, and the coordinated activity of TGFbeta family members is likely to regulate the differentiation and function of adult beta-cells, raising the possibility of developing new diabetes therapies based on TGFbeta agonists or antagonists.

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Sorted by citations

Authors
Brown, M. L., & Schneyer, A. L.
Affiliations
University of Massachusetts Amherst (US)
Corresponding author
Schneyer, Alan L.
ORCID
Brown, Melissa L.
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2010-07
Volume
21
Issue
7
Pages
441-448
ISSN
1043-2760 (ISSN-L)
DOI
10.1016/j.tem.2010.02.008
PMC
PMC2897975
OpenAlex
W2047791249
Cited by
63
References
7
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 8 · 2014: 2 · 2013: 4 · 2012: 4
FWCI
0.74
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01dk075058-03)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK075058)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
TGF-beta superfamily, beta-cell proliferation, beta cell differentiation, glucose homeostasis, type 2 diabetes, diabetes treatment
MeSH terms
Animals, Diabetes Mellitus, Type 2, Glucose, Homeostasis, Signal Transduction, Transforming Growth Factor beta, Insulin-Secreting Cells, Mice

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