CoChat
Sign Up
Cited by 383Cytokine Signaling Pathways and InteractionsImmune cells in cancerImmune Response and Inflammation

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

Cunha, F.Q., Mohcada, S., Liew, F.Y.·1992·Biochemical and Biophysical Research Communications
DOI 10.1016/0006-291x(92)91852-h
Open this paper in CoChat — free account

Abstract

A murine macrophage cell line, J774, expresses high levels of the enzyme nitric oxide synthase (NOS) and produces large amounts of nitric oxide (NO) when activated with recombinant interferon (IFN)-gamma and a low concentration of LPS (10 ng/ml). Both the expression of NOS and the production of NO were inhibited by recombinant IL-10 in a dose-dependent manner. The inhibition was effective only when the cells were pretreated with IL-10; addition of IL-10 at the same time or after IFN-gamma activation was without effect. These results demonstrate that IL-10, a product of Th2 (helper T lymphocyte 2) cells, can antagonise the function of IFN-gamma, a product of Th1 cells, by modulating the mechanism of synthesis of nitric oxide in the macrophages.

Integrity signals

Registry

Crossref · 10.1016/0006-291x(92)91852-h

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Macrophages exposed to IL-10 have lowered microbicidal activity and diminished capacity to respond to IFN-γ.

    “Macrophages themselves are affected by IL-10 in that exposure to this cytokine lowers their microbicidal activity and diminishes their capacity to respond to IFN-γ (63, 64).”

    From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [64]

  • NO increases levels of anti-inflammatory cytokine IL-10 in Treg cells and some cancer cells.

    “NO also increases levels of the anti-inflammatory cytokine interleukin-10 (IL-10) in Treg cells as well as in some cancer cells [63-65].”

    From Signaling and stress: The redox landscape in NOS2 biology (2015) · cites this paper as [65]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Cunha, F. Q., Mohcada, S., & Liew, F. Y.
Affiliations
  • Wellcome Trust (GB)
  • University of Glasgow (GB)
Corresponding author
Liew, F.Y.
ORCID
Cunha, F.Q.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
1992-02
Volume
182
Issue
3
Pages
1155-1159
ISSN
0006-291X (ISSN-L)
DOI
10.1016/0006-291x(92)91852-h
OpenAlex
W2038992843
Cited by
383
References
23
Citations by year
2026: 4 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 5
FWCI
11.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
IL-10, interferon-gamma, nitric oxide synthase, nitric oxide, macrophages, J774 cells, lipopolysaccharide, Th1/Th2 balance, cytokine antagonism, macrophage activation
MeSH terms
Amino Acid Oxidoreductases, Animals, Cell Line, Enzyme Induction, Interferon-gamma, Kinetics, Macrophages, Nitric Oxide, Recombinant Proteins, Interleukin-10, Nitric Oxide Synthase, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review