The pathway of glutamate oxidation by mitochondria isolated from different tissues

Borst, P.

doi:10.1016/0006-3002(62)91119-8

Cited by 128Mitochondrial Function and PathologyAmino Acid Enzymes and MetabolismBiochemical Acid Research Studies

The pathway of glutamate oxidation by mitochondria isolated from different tissues

Borst, P.·1962·Biochimica et Biophysica Acta

DOI 10.1016/0006-3002(62)91119-8

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Under normal and glucose-replete conditions, transamination is the dominant reaction driving glutamine anaplerosis in cultured cells.
“However, under normal and glucose-replete conditions, transamination is the dominant reaction that drives glutamine anaplerosis in cultured cells (79, 80, 81, 82).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [80]

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Authors: Borst, P.
Affiliations: University of Amsterdam (NL)
Corresponding author: Borst, P.
ORCID: Borst, P.
Venue: Biochimica et Biophysica Acta
Publisher: Elsevier BV
Published: 1962-01
Volume: 57
Issue: 1
Pages: 256-269
ISSN: 0006-3002 (ISSN-L)
DOI: 10.1016/0006-3002(62)91119-8
OpenAlex: W2032296086
Cited by: 128
References: 43
Citations by year: 2026: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2016: 2
FWCI: 10.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Keywords: glutamate oxidation, mitochondrial metabolism, glutamate dehydrogenase, aspartate aminotransferase, TCA cycle, malonate inhibition, fluoride inhibition, arsenite inhibition, alpha-ketoglutarate, liver mitochondria, heart mitochondria, skeletal muscle mitochondria, Ehrlich ascites tumor cells, decarboxylation
MeSH terms: Glutamates, Mitochondria, Oxidation-Reduction, Glutamic Acid

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