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Cited by 408Bipolar Disorder and TreatmentTreatment of Major DepressionElectroconvulsive Therapy Studies

Rapid Cycling in Manic-Depressives Induced by Tricyclic Antidepressants

Wehr, Thomas A.·1979·Archives of General Psychiatry
DOI 10.1001/archpsyc.1979.01780050065007
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Abstract

Maintenance tricyclic antidepressants induced rapid cycling between mania and depression in five female bipolar (manic-depressive) patients. Lithium carbonate did not prevent the tricyclic-induced rapid cycling, although two patients subsequently responded well to lithium carbonate alone. In these patients, the action of tricyclics can be conceptualized as accelerating rather than counteracting the natural, cyclic course of the illness in all of its phases. In this respect, tricyclics are analogous to several other drugs that are capable of modulating the frequency of oscillatory biological processes.

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Crossref · 10.1001/archpsyc.1979.01780050065007

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21 of 21 references verified0 citation errors · 0 not checkable

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  • Antidepressant medications sometimes induce, or accelerate the frequency of, rapid mood cycling.

    “Antidepressant medications sometimes induce, or accelerate the frequency of, rapid mood cycling.”

    From Bipolar mood cycles and lunar tidal cycles (2018) · cites this paper as [12]

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Authors
Wehr, T. A.
Corresponding author
Wehr, Thomas A.
ORCID
Wehr, Thomas A.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1979-05-01
Volume
36
Issue
5
Pages
555
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1979.01780050065007
OpenAlex
W2109973761
Cited by
408
References
21
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2021: 1 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 9
FWCI
15.49
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
rapid cycling, bipolar disorder, tricyclic antidepressants, lithium carbonate, female patients, biological oscillations
MeSH terms
Adolescent, Adult, Antidepressive Agents, Tricyclic, Bipolar Disorder, Circadian Rhythm, Desipramine, Dose-Response Relationship, Drug, Female, Humans, Lithium, Longitudinal Studies, Male, Middle Aged, Motor Activity, Sex Factors

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