Enzyme activity and behavior in hyperactive children grown up
Abstract
Thirty-one men, originally seen as children for problems with overactivity, distractibility, and impulsiveness, were reevaluated at ages 21-23 years. Subjects were interviewed and tested and provided a blood sample for analyses of dopamine-beta-hydroxylase (DBH), monoamine oxidase (MAO), and catechol-O-methyl-transferase (COMT). A series of Pearson correlations between the biological variables and psychological measures revealed that MAO levels were negatively associated with measures of drug involvement, cigarette use, fire-setting, and sensation seeking; DBH levels were positively associated with measures of sensation-seeking; and COMT levels were negatively associated with a measure of hostility and positively correlated with a measure of impulsiveness.
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The role of COMT in aggression was initially supported by observations of hostility in mice deficient in Comt and the negative correlation between COMT levels and hostility in men with behavioral problems as children.
“The role of COMT in aggression was initially supported by observations of hostility in mice deficient in Comt and the negative correlation between COMT levels and hostility in men with behavioral problems as children [57, 58]; reviewed in Qayyum et al. (2015) [59].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [58]
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Hess, C., Reif, A., Strobel, A., Boreatti-Hümmer, A., Heine, M., Lesch, K.-P., & Jacob, C. P. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0138-0 · Cited by 104 · see citing works
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Genetics of child aggression, a systematic review
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- Authors
- Kuperman, S., Kramer, J., & Loney, J.
- Affiliations
- University of Iowa (US)
- ORCID
- Kramer, John
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1988-08
- Volume
- 24
- Issue
- 4
- Pages
- 375-383
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2080251936
- Cited by
- 15
- References
- 32
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2019: 1 · 2015: 2
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- hyperactive children, adult outcomes, dopamine beta-hydroxylase, monoamine oxidase, catechol-O-methyltransferase, enzyme activity, impulsivity, sensation seeking, hostility, substance use, cigarette smoking, fire-setting, overactivity, distractibility
- MeSH terms
- Adult, Aggression, Arousal, Attention Deficit Disorder with Hyperactivity, Catechol O-Methyltransferase, Dopamine beta-Hydroxylase, Humans, Impulsive Behavior, Male, Monoamine Oxidase, Psychological Tests
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