The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies

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An Investigation of Factors Increasing the Risk of Aggressive Behavior among Schizophrenic Inpatients

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Agitation and Aggression in Alzheimer’s Disease: An Update on Pharmacological and Psychosocial Approaches to Care

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Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance

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Advancing Post-Stroke Depression Research: Insights from Murine Models and Behavioral Analyses

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Drosophila mutants lacking the glial neurotransmitter-modifying enzyme Ebony exhibit low neurotransmitter levels and altered behavior

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Physical activity and gene association with human obesity

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The epigenome: key to understanding and predicting gout flares

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Dark Triad traits mediate the interaction between childhood abuse and COMT Val158Met polymorphism on aggression among incarcerated Chinese males

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The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

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Violence Rewired

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Pharmacodynamic Gene Testing in Prader-Willi Syndrome

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Peripheral catecholamine systems: an evolutionary perspective

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Self-reported cancer-related cognitive impairment is associated with perturbed neurotransmission pathways

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Possible Biomarkers and Contributing Factors of Psychosis: a Review

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Therapeutic potential of Asplenium caudatum in Aluminum Chloride-induced Alzheimer’s diseases: An insight of integrative approaches

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Behavioral Genetics of Aggression and Intermittent Explosive Disorder

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Dog behaviour : Intricate picture of genetics, epigenetics, and human-dog relations

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Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework

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Genome‐wide association study of novel feedlot profitability‐related traits in Nelore cattle

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COMT Variants are Associated With Breast and Nipple Pain

ADERIBIGBE, T. B., Kelleher, S. L., Henderson, W. A., Prescott, S. M., Young, E. E., & Lucas, R. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.104568 · Cited by 3 · see citing works

Non-invasive genotyping with a massively parallel sequencing panel for the detection of SNPs in HPA-axis genes

Gutleb, D. R., Ostner, J., Schülke, O., Wajjwalku, W., Sukmak, M., Roos, C., & Noll, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-34223-y · Cited by 3 · see citing works

Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice

Davtyan, H., Naguib, S. A., Voskobiynyk, Y., Chadarevian, J. P., Capocchi, J. K., Giacchino, J. L., Eskandari‐Sedighi, G., DeNittis, V. R., Ford, J. B., Agababian, A., et al. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00978-6 · Cited by 2 · see citing works

Stress in Fetal Life Ex Utero: Very Preterm Infants

Levine, T. A., & GRUNAU, R. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-60159-1_11 · Cited by 2 · see citing works

Toxoplasmosis-related Psychological, Behavioral, Neurological, and Hormonal Changes: A Literature Review

(2023) · European Journal of Medical and Health Sciences · doi:10.34104/ejmhs.023.01280144 · Cited by 2 · see citing works

Potential effects of genetic polymorphism on anesthesia use for COVID-19 infected patients at intensive care unit

Sara, A. R., Mohamed, R., Eslam, M. S., & Sabri Nagwa, A. (2022) · Scientific Journal of Genetics and Gene Therapy · doi:10.17352/sjggt.000020 · Cited by 2 · see citing works

Molecular Genetics and Human Behavior☆

Forero, D. A., Pereira‐Morales, A. J., & González‐Giraldo, Y. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.06489-0 · Cited by 2 · see citing works

Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility

Tudor, L., Podobnik, J., Erjavec, G. N., Perković, M. N., Harro, J., Kanarik, M., Marčinko, D., Štrac, D. Š., Cusek, M., Kovač, V., et al. (2025) · Biomolecules · doi:10.3390/biom15040554 · Cited by 1 · see citing works

Preliminary insights into the association between the well-being spectrum and temporomandibular disorders

Chen, X., Zheng, C., Xu, J., Wang, Q., Zhao, Z., & Jiang, Q. (2025) · Clinical Oral Investigations · doi:10.1007/s00784-025-06377-3 · Cited by 1 · see citing works

A Combined Impact of Neurotransmitter System Genes and Social/Lifestyle Factors on Aggressive Behavior

Казанцева, А. В., Davydova, Y. D., Mustafin, R. N., Lobaskova, M. M., Malykh, S. B., & Khusnutdinova, E. K. (2025) · Russian Journal of Genetics · doi:10.1134/s102279542570125x · Cited by 1 · see citing works

Adenosine signals an imbalance between activity and supply in privileged cells

Nedbalová, P., & Dolezal, T. (2026) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2026.02.007 · Cited by 1 · see citing works

Nitric oxide inhibition ameliorates cortical proteomic changes in the Cntnap2-/- and Shank3Δ4–22 mouse models of autism spectrum disorder

Bazbaz, W., Kartawy, M., Халиулин, И. Г., & Amal, H. (2026) · Molecular Autism · doi:10.1186/s13229-026-00716-1 · Cited by 1 · see citing works

Structural Violence

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.006 · Cited by 1 · see citing works

Genomic studies in Montana Tropical Composite cattle

Grigoletto, L. (2020) · doi:10.11606/t.74.2020.tde-13042021-153436 · Cited by 1 · see citing works

Behavioral Genetics

Gaysina, D. (2022) · Wiley eBooks · doi:10.1002/9781119679028.ch2 · Cited by 1 · see citing works

Behavioural, physiological, and genetic drivers of copingPreprint

Bhattacharjee, D., Guðjónsdóttir, A. R., Chova, P. E., Middelburg, E., Jäckels, J., de Groot, N. G., Wallner, B., Massen, J. J. M., & Pflüger, L. S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.28.555090 · Cited by 1 · see citing works

Genetic Basis of Idiosyncratic Responses to Alcoholism

Osuji, C. E. (2016) · European Journal of Clinical and Biomedical Sciences · doi:10.11648/j.ejcbs.20160206.12

Integrating behavior, hormones and genes associated with the primate HPA-axis

Gutleb, D. R. (2019) · doi:10.53846/goediss-7382

Developmental Factors in Violence Propensity

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.005

CATECHOL O-METHYLTRANSFERASE VAL158/MET AND HYPERTENSION: A META-ANALYSIS

Merzah, M. A., & Natae, S. F. (2021) · Malaysian Journal of Public Health Medicine · doi:10.37268/mjphm/vol.21/no.2/art.878

Pharmaceutical Interventions

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.009

Major UN Initiatives to Address Violence, 1986–2018

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.013

Foreword

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.015

Introduction and Overview

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.001

The Prospect of Human Violence

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.002

The Biology of Violence

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.004

Psychosocial Interventions

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.010

Advancing a Global Public Health Response to Violence

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.007

Rewiring Our Expectations

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.012

Changing Structures

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.011

Risk Assessment

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.008

The Roots of Human Violence

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.003

Peer Review #2 of "Sociality genes are associated with human-directed social behaviour in golden and Labrador retriever dogs (v0.2)"

(2018) · PeerJ · doi:10.7287/peerj.5889v0.2/reviews/2

Index

Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.014

Peer Review #1 of "Sociality genes are associated with human-directed social behaviour in golden and Labrador retriever dogs (v0.1)"

(2018) · PeerJ · doi:10.7287/peerj.5889v0.1/reviews/1

Further Reading

(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-802629-8.16001-2

Peer Review #2 of "Sociality genes are associated with human-directed social behaviour in golden and Labrador retriever dogs (v0.1)"

(2018) · PeerJ · doi:10.7287/peerj.5889v0.1/reviews/2

Impulsive aggression: recognition and choice of pharmacotherapy

Snedkov, E. V. (2023) · Neurology Bulletin · doi:10.17816/nb119902

The meaning of lithium and naltrexone pharmacotherapy in the treatment of borderline personality disorder – a narrative review

Wingralek, Z. J., Marczak, A., Tomasik, J. M., Giermasiński, A., & Dzikowski, M. (2023) · Current Problems of Psychiatry · doi:10.12923/2353-8627/2023-0018

Evaluation of the association COMT Val158Met variant and childhood trauma on aggression in Turkish SCZ patients

Aydın, P. Ç., Yıldırım, Y. E., Erol, A., Nursal, A. F., Atar, A. Ö., Oyacı, Y., Ayar, Y., Kişioğlu, S., & Pehlivan, S. (2024) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2024.2302524

The role of CRHR1 and FKBP5 genes in juvenile delinquency among children aged between 12 and 18 years: a case–control study

Akbaba, M., Isır, A. B., kılıç, M., & Nacarkahya, G. (2024) · Journal of Forensic Psychiatry and Psychology · doi:10.1080/14789949.2024.2378843

Criterion validity of the genetic addiction risk severity (GARS) as a marker of reward deficiency in polydrug addiction: a multi-center study

Blum, K., Haberstick, B. C., Smolen, A., Han, D. C., Elman, I., Dennen, C. A., Oscar‐Berman, M., Smith, D. E., Simpatico, T. A., Giordano, J., et al. (2025) · Journal of Translational Genetics and Genomics · doi:10.20517/jtgg.2024.56

Gene Expression Study of Some Addictive Genes in the Hippocampal Region of Albino Rats Treated with a Brand of Energy Drink at Sub-Chronic PeriodPreprint

Gandawa, Y. H. A., Dibal, F. S., Sadiq, G. U., & Yerima, T. S. (2025) · Research Square · doi:10.21203/rs.3.rs-7134304/v1

Genetic risk factors for the development of chronic orofacial pain and masticatory muscle dysfunction in temporomandibular joint pain-dysfunction syndrome

Вадимовна, К. Ю., & Efimov, E. V. (2025) · Russian neurological Journal · doi:10.30629/2658-7947-2025-30-3-4-12

Virtual screening of potential inhibitors against catechol-o-methyltransferase (COMT) for temporomandibular joint disorders

Thorat, S. U., Nagachandran, K., Varghese, R. M., & Thomas, L. R. (2025) · Journal of Orthodontic Science · doi:10.4103/jos.jos_2_25

New 4-Aminophenazone derivatives: synthesis, design, and docking analysis as selective COMT inhibitors

Yaseen, Y. S., Tawfeeq, M. F., Hamdoon, Y. S., & Mahmood, A. A. R. (2025) · Journal Of Advanced Pharmacy Education And Research · doi:10.51847/f7txs6cksy

A systematic review and a meta-analysis of genetic studies linking dopaminergic alleles to aggression: Where are we now?

Palumbo, S., Grassi, G., Mariotti, V., & Pellegrini, S. (2025) · Aggression and Violent Behavior · doi:10.1016/j.avb.2025.102096

Disruption of Dopamine Homeostasis by Psychostimulants

Torres, J., Bredenkamp, C., Vazquez, A., & Chivero, E. T. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05769-0

A biopsychosocial perspective of cognitive conflict: Interacting dimensions and theoretical propositions

Gupta, R. K., & Walia, Y. (2026) · Acta Psychologica · doi:10.1016/j.actpsy.2026.106586 · Cited by 3 · see citing works

Catechol- O -methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis, and protein folding in schizophrenia

Tripathi, S. J., Chakraborty, S., Wood, N. B., Hoopes, D., Barker, S., Vázquez‐Rosa, E., An, J., Ma, C., Hou, Y., Sharma, S. M., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2606205123

Association of stress-related genetic risk and lifestyle factors with BMI in Korean adults

Lee, G. Y., Lee, J., Kim, J., Chung, K., & Han, S. N. (2026) · Nutrition Research and Practice · doi:10.4162/nrp.2026.20.5.820

Association Between Aggressive Behavior and A Functional Polymorphism in the COMT Gene

Wang, M., & Zhang, W. (2010) · Cited by 3 · see citing works

Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population

Kim, Y., Kim, J., Kim, S. J., Lee, D.-E., & Min, S. K. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.07.009 · Cited by 29 · see citing works

Association study between aggression behavior in schizophrenics and catechol-O-methyltransferase gene polymorphism

Jian-zhon, Y. (2005) · Zhongguo shenjing jingshen jibing zazhi · Cited by 1 · see citing works

Physical and verbal aggressive behavior and COMT genotype: Sensitivity to the environment

Tuvblad, C., Narusyte, J., Comasco, E., Andershed, H., Andershed, A., Colins, O. F., Fanti, K. A., & Nilsson, K. W. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32430 · Cited by 28 · see citing works

Catechol-O-Methyltransferase Gene Val158Met Polymorphism Moderates the Effect of Social Exclusion and Inclusion on Aggression in Men: Findings From a Mixed Experimental Design

Wang, M., Chen, P., Li, H., Kemp, A. H., & Zhang, W. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.622914 · Cited by 10 · see citing works