Cited by 76Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychosomatic Disorders and Their TreatmentsNeurotransmitter Receptor Influence on Behavior

Isoproterenol-induced panic attacks

Pohl, Robert, Yeragani, Vikram K., Balon, Richard, Rainey, John M., Lycaki, Helene, Ortiz, Aurelio, Berchou, Richard, Weinberg, Paula·1988·Biological Psychiatry

Abstract

Eighty-six panic disorder patients and 45 nonpsychiatric controls were infused with isoproterenol at a rate of 1 microgram/min for up to 20 min in a placebo-controlled, double-blind study. Sixty-six percent of panic disorder patients experienced panic attacks during isoproterenol infusions, compared to 16% during placebo infusions. Nine percent of control subjects panicked with isoproterenol, but none panicked with placebo. Patients were more sensitive than controls to the anxiogenic effects of isoproterenol, as measured by subject self-ratings on a panic description scale. The frequency of panic attacks induced in patients was related to the dosage of isoproterenol; 79% of the patients who received a mean of 18.5 ng/min/kg of isoproterenol panicked. The panic attacks experienced by patients during isoproterenol infusions were similar to those experienced during placebo infusions.

Integrity signals

Registry

Crossref · 10.1016/0006-3223(88)90224-7

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Pohl, R., Yeragani, V. K., Balon, R., Rainey, J. M., Lycaki, H., Ortiz, A., Berchou, R., & Weinberg, P.
Affiliations
Wayne State University (US)
Corresponding author
Pohl, Robert
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1988-12
Volume
24
Issue
8
Pages
891-902
ISSN
0006-3223 (ISSN-L)
OpenAlex
W1971545103
Cited by
76
References
41
Citations by year
2026: 4 · 2025: 4 · 2024: 7 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 1 · 2014: 1 · 2012: 2
FWCI
1.05
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
isoproterenol, panic attacks, panic disorder, beta-adrenergic agonists, anxiogenic effects, placebo response, beta-adrenergic blockade
MeSH terms
Adolescent, Adult, Clinical Trials as Topic, Dose-Response Relationship, Drug, Double-Blind Method, Fear, Female, Glucose, Humans, Infusions, Intravenous, Isoproterenol, Lactates, Male, Middle Aged, Panic, Lactic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review