Isoproterenol-induced panic attacks
Abstract
Eighty-six panic disorder patients and 45 nonpsychiatric controls were infused with isoproterenol at a rate of 1 microgram/min for up to 20 min in a placebo-controlled, double-blind study. Sixty-six percent of panic disorder patients experienced panic attacks during isoproterenol infusions, compared to 16% during placebo infusions. Nine percent of control subjects panicked with isoproterenol, but none panicked with placebo. Patients were more sensitive than controls to the anxiogenic effects of isoproterenol, as measured by subject self-ratings on a panic description scale. The frequency of panic attacks induced in patients was related to the dosage of isoproterenol; 79% of the patients who received a mean of 18.5 ng/min/kg of isoproterenol panicked. The panic attacks experienced by patients during isoproterenol infusions were similar to those experienced during placebo infusions.
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Older evidence shows that isoproterenol can trigger panic and anxiety in experimental settings.
“older evidence that isoproterenol can provoke panic and anxiety in experimental settings (Rainey et al., 1984; Balon et al., 1990; Pohl et al., 1988; Pohl et al., 1990).”
From Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome (2018) · cites this paper as Pohl et al., 1988
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Self-citation
- Authors
- Pohl, R., Yeragani, V. K., Balon, R., Rainey, J. M., Lycaki, H., Ortiz, A., Berchou, R., & Weinberg, P.
- Affiliations
- Wayne State University (US)
- Corresponding author
- Pohl, Robert
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1988-12
- Volume
- 24
- Issue
- 8
- Pages
- 891-902
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1971545103
- Cited by
- 76
- References
- 41
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 1 · 2014: 1 · 2012: 2
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- isoproterenol, panic attacks, panic disorder, beta-adrenergic agonists, anxiogenic effects, placebo response, beta-adrenergic blockade
- MeSH terms
- Adolescent, Adult, Clinical Trials as Topic, Dose-Response Relationship, Drug, Double-Blind Method, Fear, Female, Glucose, Humans, Infusions, Intravenous, Isoproterenol, Lactates, Male, Middle Aged, Panic, Lactic Acid
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