Electroencephalographic sleep in clinically stable schizophrenic patients: Two-weeks versus six weeks neuroleptic-free
Abstract
EEG sleep studies in schizophrenic patients are influenced by alterations in clinical state and medication status. The current study defines longitudinal alterations in electroencephalographic (EEG) sleep for 10 healthy men who were schizophrenic patients who remained relatively clinically stable during a double-blind neuroleptic withdrawal study. Clinical assessments and EEG sleep studies were performed at baseline on haloperidol, and then at 2-week and 6-week drug-free periods. Sleep continuity and rapid eye movement (REM) sleep measures declined not only between the haloperidol baseline and 2-week drug-free conditions, but continued to decline from 2-week to 6-weeks neuroleptic-free. Alterations in EEG sleep from the 2-week to 6-week haloperidol-free assessments did not correlate with changes in clinical symptoms suggesting effects related to drug-withdrawal or subclinical state changes. These results show that despite relative clinical stability over time, the EEG sleep of schizophrenic patients continues to change following withdrawal of a neuroleptic and is dependent on the duration of the drug-free interval.
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In one smaller study, sleep variables displayed no relationship with clinical symptoms.
“although in one smaller study sleep variables displayed no relationship with clinical symptoms (Nofzinger, van Kammen, Gilbertson, Gurklis, & Peters, 1993).”
From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Nofzinger, van Kammen, Gilbertson, Gurklis, & Peters, 1993
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- Authors
- Nofzinger, E. A., van Kammen, D. P., Gilbertson, M. W., Gurklis, J. A., & Peters, J. L.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Nofzinger, Eric A.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 33
- Issue
- 11-12
- Pages
- 829-835
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2039465869
- Cited by
- 61
- References
- 33
- Citations by year
- 2026: 5 · 2025: 1 · 2023: 1 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2013: 3 · 2012: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01 MH-44841, MH16804, T32MH016804)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- schizophrenia, sleep EEG, neuroleptic withdrawal, haloperidol, drug-free interval, REM sleep, sleep continuity, longitudinal EEG changes, clinical stability
- MeSH terms
- Adult, Double-Blind Method, Electroencephalography, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Reaction Time, Schizophrenia, Schizophrenic Psychology, Sleep, Substance Withdrawal Syndrome, Time Factors, Antipsychotic Agents
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