Abnormal sleep spindles, memory consolidation, and schizophrenia
Open accessAbstract
There is overwhelming evidence that sleep is crucial for memory consolidation. Patients with schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a defining oscillation of non-rapid eye movement (NREM) Stage 2 sleep that, in coordination with other NREM oscillations, mediate memory consolidation. In schizophrenia, the spindle deficit correlates with impaired sleep-dependent memory consolidation, positive symptoms, and abnormal thalamocortical connectivity. These relations point to dysfunction of the thalamic reticular nucleus (TRN), which generates spindles, gates the relay of sensory information to the cortex, and modulates thalamocortical communication. Genetic studies are beginning to provide clues to possible neurodevelopmental origins of TRN-mediated thalamocortical circuit dysfunction and to identify novel targets for treating the related memory deficits and symptoms. By forging empirical links in causal chains from risk genes to thalamocortical circuit dysfunction, spindle deficits, memory impairment, symptoms, and diagnosis, future research can advance our mechanistic understanding, treatment, and prevention of schizophrenia.
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This impaired connectivity in turn might disturb sensory gating and processing of external and internal signals that could then contribute to the emergence of hallucinations.
“This impaired connectivity in turn might disturb sensory gating and processing of external and internal signals that could then contribute to the emergence of hallucinations. 59”
From Towards an Integrative Account of Potential Mechanisms Mediating the Path From Sleep Dysfunction to Hallucinations (2025) · cites this paper as [59]
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Self-citation
Flagged first, then by citations
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Cited by
Sorted by citations
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Targeting sleep oscillations to improve memory in schizophrenia
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- Authors
- Manoach, D. S., & Stickgold, R.
- Affiliations
- Harvard University (US)
- Beth Israel Deaconess Medical Center (US)
- Venue
- Annual Review of Clinical Psychology
- Publisher
- Annual Reviews
- Published
- 2019-05-07
- Volume
- 15
- Issue
- 1
- Pages
- 451-479
- ISSN
- 1548-5943 (ISSN-L)
- 1548-5951
- PMC
- PMC7307009
- OpenAlex
- W2915405525
- Cited by
- 157
- References
- 149
- Citations by year
- 2026: 21 · 2025: 22 · 2024: 24 · 2023: 16 · 2022: 28 · 2021: 23 · 2020: 14 · 2019: 9
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (K24MH099421, R01 MH 67720, R01MH107579, R01MH048832, R01MH092638)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sleep spindles, memory consolidation, schizophrenia, thalamocortical connections, thalamic reticular nucleus, NREM sleep, positive symptoms, risk genes, neurodevelopmental origin
- MeSH terms
- Memory Consolidation, Cerebral Cortex, Humans, Nerve Net, Schizophrenia, Sleep Stages, Thalamic Nuclei, Brain Waves
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