Cited by 690Nicotinic Acetylcholine Receptors StudySchizophrenia research and treatmentNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

Freedman, Robert, Hall, Michael, Adler, Lawrence E., Leonard, Sherry·1995·Biological Psychiatry

DOI 10.1016/0006-3223(94)00252-x

Open this paper in CoChat — free account

Abstract

This study tests the hypothesis that nicotinic cholinergic receptors, including those sensitive to the antagonist alpha-bungarotoxin, are decreased in the hippocampus of schizophrenics. The hypothesis is derived from the finding that alpha-bungarotoxin causes a defect in the inhibitory gating of auditory-evoked potentials in laboratory animals that resembles a defect in auditory sensory gating observed in schizophrenics. Nicotine transiently normalizes this psychophysiological deficit in schizophrenic patients. Postmortem brain tissue was obtained from eight schizophrenic and eight age-matched nonschizophrenic subjects. Sections of the hippocampus were labeled with [125I alpha-bungarotoxin and imagined by autoradiography. Binding of the nicotinic agonist [3H]-cytisine was determined in tissue homogenates. alpha-Bungarotoxin labeled a population of putative interneurons in the hippocampus, primarily in the dentate gyrus and the CA3 region of Ammon's horn. This labeling was significantly decreased in the tissue from the schizophrenic patients, with seven or eight patients below the range of the nonschizophrenic subjects. There was also a significant decrease in the binding of cytisine. The results were not related to generalized hippocampal cell loss, drug exposure at time of death, or smoking history. This initial study suggests that schizophrenic patients have fewer nicotinic receptors in the hippocampus, a condition which may lead to failure of cholinergic activation of inhibitory interneurons, manifest clinically as decreased gating of response to sensory stimulation.

Integrity signals

Registry

Crossref · 10.1016/0006-3223(94)00252-x

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Progress in experimental personality research
Maher, W. B., & Maher, B. A. (1964) · Academic Press eBooks · Cited by 2,347
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471
Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia.
Adler, L. E., Pachtman, E., Franks, R. D., Pecevich, M., Waldo, M. C., & Freedman, R. (1982) · PubMed · Cited by 896
Self-citation
Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients
Benes, F. M. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810350036005 · Cited by 891
Basal Ganglia and Limbic System Pathology in Schizophrenia: A Morphometric Study of Brain Volume and Shrinkage
Bogerts, B. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790310046006 · Cited by 880
A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.
Flores, C. M., Rogers, S. W., Pabreza, L. A., Wolfe, B. B., & Kellar, K. J. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08832-7 · Cited by 880
Cigarette smoking: implications for psychiatric illness
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.4.546 · Cited by 723
Normalization of auditory physiology by cigarette smoking in schizophrenic patients
Adler, L. E., Hoffer, L., Wiser, A., & Freedman, R. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.12.1856 · Cited by 679
Self-citation
Cigarette smoking in schizophrenia: relationship to psychopathology and medication side effects
GOFF, D. C., Henderson, D. C., & Amico, E. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.9.1189 · Cited by 576

Show all 55 references

Research works printed but not linked: 3

Daviss, 1993, Calbindin- and calretinin-immunoreactive local circuit neurons are increased in density in the prefrontal cortex of schizophrenic subjects, Neurosci Abstracts, 19, 201
Goff, 1980, Neural origins of long latency evoked potentials recorded from the depth and from the cortical surface of the brain in man, Prog Clin Neurophysiol, 7, 126
Klein, 1991, On the influence of smoking upon smooth pursuit eye movements of schizophrenics and normal controls, J Psychophysiology, 5, 361

Sorted by citations

Items 501–600 of 690

Cholinergic Functioning, Cognition, and Anticholinergic Medication Burden in Schizophrenia
Joshi, Y. B. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_400 · Cited by 11
SARS-CoV-2 Spike Protein Downregulates Cell Surface α7nAChR through a Helical Motif in the Spike Neck
Tillman, T. S., Chen, Q., Bondarenko, V., Coleman, J. A., Xu, Y., & Tang, P. S. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00610 · Cited by 12
Differential signalling induced by α7 nicotinic acetylcholine receptors in hippocampal dentate gyrus in vitro and in vivo
Cheng, Q., Lamb, P. W., Stevanovic, K. D., Bernstein, B. J., Fry, S. A., Cushman, J. D., & Yakel, J. L. (2021) · The Journal of Physiology · doi:10.1113/jp280505 · Cited by 11
Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population
Kishi, T., Ikeda, M., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Kawashima, K., Okochi, T., Inada, T., Ozaki, N., & Iwata, N. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0114-8 · Cited by 11
Cholinergic mechanisms in schizophrenia: Current concepts
Raedler, T. J., & Tandon, R. (2006) · Current Psychosis & Therapeutics Reports · doi:10.1007/bf02629410 · Cited by 11
Opportunities in precision psychiatry using PET neuroimaging in psychosis
Coughlin, J. M., Horti, A. G., & Pomper, M. G. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.03.016 · Cited by 11
Nicotinic Acetylcholine Receptor Alterations in Autism Spectrum Disorders – Biomarkers and Therapeutic Targets
Anand, R., Stephanie, A., Ponath, G. D., Jordan, I., Nasir, M. I., & Susan, B. (2011) · InTech eBooks · doi:10.5772/20752 · Cited by 11
Molecular Pathology of the Nicotinic Acetylcholine Receptor
Barrantes, F. J. (1998) · Springer eBooks · doi:10.1007/978-3-662-40279-5_8 · Cited by 11
Are Differential Behavioral Responses to Smoking and Smoking Cessation in Schizophrenia Related to Nicotinic Receptor Levels?
Leonard, S. S. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00382-2 · Cited by 11
Self-citation
Hippocampal Availability of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis
Wong, N. R., Rubin, L. H., Harrington, C. K., Jenkins, K. R., Shinehouse, L. K., Yoon, M., Kilgore, J. J., Soule, A. R., Lesniak, W. G., Rowe, S. P., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.27163 · Cited by 10
Assessing the acute effects of CDP-choline on sensory gating in schizophrenia: A pilot study
Aidelbaum, R., Labelle, A., Baddeley, A., & Knott, V. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117746903 · Cited by 10
Cocaine addicts prone to cocaine-induced psychosis have lower body mass index than cocaine addicts resistant to cocaine-induced psychosis--Implications for the cocaine model of psychosis proneness.
Rosse, R. B., Deutsch, S. I., & Chilton, M. (2005) · PubMed · Cited by 10
Discovery of fused heterocyclic carboxamide derivatives as novel α7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation
Xue, Y., He, X., Yang, T., Wang, Y., Liu, Z., Zhang, G., Wang, Y., Wang, K., Zhang, L., & Zhang, L. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111618 · Cited by 10
The smoking cessation drug varenicline improves deficient P20–N40 inhibition in DBA/2 mice
Wildeboer, K. M., & Stevens, K. E. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.07.001 · Cited by 9
Design and synthesis of a novel series of 4-heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR
Iwuagwu, C. I., King, D., McDonald, I. M., Cook, J., Zusi, F. C., Hill, M. D., Mate, R. A., Fang, H., Knox, R. J., Gallagher, L., et al. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.01.058 · Cited by 9
DNA methylation regulates CHRNA7 transcription and can be modulated by valproate
Dyrvig, M., Mikkelsen, J. D., & Lichota, J. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.04.015 · Cited by 9
Nicotine Dependence in Schizophrenia: Contributions of Nicotinic Acetylcholine Receptors
Cole, R. D., & Parikh, V. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813035-3.00017-4 · Cited by 9
Desformylflustrabromine, a positive allosteric modulator of α4β2-containing nicotinic acetylcholine receptors, enhances cognition in rats
Nikiforuk, A., Litwa, E., Krawczyk, M., Popik, P., & Arias, H. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00092-4 · Cited by 9
Cognitive Effects of Nicotine
Sofuoglu, M., Herman, A. I., Robinson, C. D., & Waters, A. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418679-8.00012-5 · Cited by 8
Onde P50 dans la schizophrénie
Houy, E., & Thibaut, F. (2007) · Encyclopédie médico-chirurgicale. Psychiatrie · doi:10.1016/s0246-1072(07)48130-5 · Cited by 9
Chrna7 genotype is linked with alpha7 nicotinic receptor expression but not alpha7 RNA levels
Brooks, N. P., Mexal, S., & Stitzel, J. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.01.026 · Cited by 9
Nicotine effects in adolescence and adulthood on cognition and α4β2-nicotinic receptors in the neonatal ventral hippocampal lesion rat model of schizophrenia
Berg, S. A., Sentir, A. M., Bell, R. L., Engleman, E. A., & Chambers, R. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3800-2 · Cited by 10
CDP-choline and galantamine, a personalized α7 nicotinic acetylcholine receptor targeted treatment for the modulation of speech MMN indexed deviance detection in healthy volunteers: a pilot study
Choueiry, J., Blais, C. M., Shah, D. K., Smith, D., Fisher, D. J., Ilivitsky, V., & Knott, V. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05646-1 · Cited by 9
Event-Related Potentials (ERPs) in the Study of Schizophrenia: How Preclinical ERP Studies have Contributed to our Understanding of Schizophrenia
Phillips, J. M., Maxwell, C. R., Ehrlichman, R. S., & Siegel, S. J. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_17 · Cited by 9
Long-lasting changes in neural networks to compensate for altered nicotinic input
John, D., & Berg, D. K. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.020 · Cited by 9
Preclinical Evaluation of Novel PET Probes for Dementia
Cools, R., Kerkhofs, K., Leitao, R. C. F., & Bormans, G. M. (2023) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2023.03.004 · Cited by 9
The separate and combined effects of monoamine oxidase A inhibition and nicotine on the mismatch negativity event related potential
Smith, D., Fisher, D. J., Blier, P., Ilivitsky, V., & Knott, V. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.07.008 · Cited by 8
Nicotinic acetylcholine receptor expression on B-lymphoblasts of healthy versus schizophrenic subjects stratified for smoking: [3H]-nicotine binding is decreased in schizophrenia and correlates with negative symptoms
Luckhaus, C., Henning, U., Ferrea, S., Musso, F., Mobascher, A., & Winterer, G. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0743-1 · Cited by 8
Nicotine Administration Normalizes Behavioral and Neurophysiological Perturbations in the MAM Rodent Model of Schizophrenia
Weeks, J. J., Grace, A. A., & Sved, A. F. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab064 · Cited by 8
The Neurochemistry of Schizophrenia
Moghaddam, B., & Krystal, J. H. (2003) · Wiley eBooks · doi:10.1002/9780470987353.ch19 · Cited by 8
Targeting Neuronal Alpha7 Nicotinic Acetylcholine Receptor Upregulation in Age-Related Neurological Disorders
Abraham, S. M., Suresh, S., & Komal, P. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01586-6 · Cited by 8
Nicotine Ameliorates Emotional and Cognitive Impairments Induced by Neonatal PolyI:C Treatment in Mice~!2009-12-18~!2010-07-05~!2010-09-09~!
Yu, J. (2010) · The Open Behavioral Science Journal · doi:10.2174/1874230001004010009 · Cited by 6
Influence of muscarinic M1 receptor antagonism on brain choline levels and functional connectivity in medication-free subjects with psychosis: A placebo controlled, cross-over study
Vingerhoets, C., Bakker, G., Schrantee, A., van der Pluijm, M., Bloemen, O., Reneman, L., Caan, M. W. A., Booij, J., & van Amelsvoort, T. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.06.005 · Cited by 7
Effectiveness of multimodal interventions focused on smoking cessation in patients with schizophrenia: A systematic review
Pinho, S., Rocha, V., & Vieira‐Coelho, M. A. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.03.012 · Cited by 9
Evolution of the human CNS cholineric system: has this resulted in the emergence of psychiatric disease?
Dean, B. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670903270431 · Cited by 7
Involvement of Neuronal Nicotinic Receptors in Disease
Clementi, F., COURT, J. A., & Perry, E. A. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57079-7_25 · Cited by 7
The Prenatal Hypoxic Pathology Associated with Maternal Stress Predisposes to Dysregulated Expression of the chrna7 Gene and the Subsequent Development of Nicotine Addiction in Adult Offspring
Stratilov, V. A., Vetrovoy, O. V., Potapova, S., & Tyulkova, E. I. (2024) · Neuroendocrinology · doi:10.1159/000536214 · Cited by 6
Theoretical study of the binding profile of an allosteric modulator NS-1738 with a chimera structure of the α7 nicotinic acetylcholine receptor
Kuang, G., Wang, X., Halldin, C., Nordberg, A. K., Långström, B., Ågren, H., & Tu, Y. (2016) · Physical Chemistry Chemical Physics · doi:10.1039/c6cp02278b · Cited by 6
A-582941, cholinergic alpha 7 nicotinic receptor agonist, improved cognitive and negative symptoms of the sub-chronic MK-801 model of schizophrenia in rats
Ünal, G., & Arıcıoğlu, F. (2017) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2017.1379716 · Cited by 6
Gulf War illness associated with abnormal auditory P1 event-related potential: Evidence of impaired cholinergic processing replicated in a national sample
Tillman, G. D., Spence, J. S., Briggs, R. W., Haley, R. W., Hart, J., & Kraut, M. A. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.11.006 · Cited by 6
Nicotine effect on mismatch negativity in smoking and nonsmoking patients with schizophrenia
Inami, R., & Kirino, E. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.01.002 · Cited by 6
[Smoking and schizophrenia: where is the biological connection?].
Üneri, Ö. Ş., Tural, Ü., & Memik, N. Ç. (2006) · PubMed · Cited by 6
Involvement of neuronal nicotinic receptor in psychiatric disorders.
Suemaru, K., Araki, H., & Gomita, Y. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.119.295 · Cited by 6
Psychiatry's Remarkable Journey: The Past 40 Years
Pardes, H. (2003) · Psychiatric Services · doi:10.1176/appi.ps.54.6.896 · Cited by 6
Aberrations in Nicotinic Acetylcholine Receptor Structure, Function, and Expression: Implications in Disease
Salamone, F. N., & Zhou, M. (2020) · McGill Journal of Medicine · doi:10.26443/mjm.v5i2.573 · Cited by 6
History of Antipsychotic Drug Development
Shankar, G. S., & Radhakrishnan, R. (2011) · Pharmaceutical Sciences Encyclopedia · doi:10.1002/9780470571224.pse465 · Cited by 6
Developmental windows for effects of choline and folate on excitatory and inhibitory neurotransmission during human gestation
Hunter, S. K., Hoffman, M. C., D’Alessandro, A., & Freedman, R. (2024) · Developmental Psychobiology · doi:10.1002/dev.22453 · Cited by 5
Self-citation
Neuregulin1 gene variants as a biomarker for cognitive impairments in patients with schizophrenia
Ananloo, E. S., Yoosefee, S., & Karimipour, M. (2020) · The European Journal of Psychiatry · doi:10.1016/j.ejpsy.2019.12.004 · Cited by 5
Unanswered questions in the regulation and function of the duplicated α7 nicotinic receptor gene CHRFAM7A
Leonard, S. S., & Benfante, R. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106783 · Cited by 5
Self-citation
Switching Operation Modes in the Neocortex via Cholinergic Neuromodulation
Puigbò, J.-Y., Arsiwalla, X. D., González‐Ballester, M. Á., & Verschure, P. F. M. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01764-w · Cited by 5
Preclinical and Clinical Aspects of Nicotinic Acetylcholine Receptor Imaging
Brust, P., Deuther‐Conrad, W., Donat, C. K., Barthel, H., Riss, P. J., Paterson, L. M., Hoepping, A., Sabri, O., & Cumming, P. D. (2020) · Springer eBooks · doi:10.1007/978-3-030-53176-8_18 · Cited by 5
Alterations of Neurotransmitter Receptors in Schizophrenia: Evidence from Postmortem Studies
Kristiansen, L. V., Cowell, R. M., Biscaia, M., McCullumsmith, R. E., & Meador‐Woodruff, J. H. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_14 · Cited by 5
Neurotransmission
Hashimoto, K., & Hattori, E. (2007) · Medical psychiatry · doi:10.3109/9781420019544.004 · Cited by 5
Molecular Imaging of 7 Nicotinic Acetylcholine Receptors In Vivo: Current Status and Perspectives
Brust, P., & Deuther‐Conrad, W. (2012) · InTech eBooks · doi:10.5772/23787 · Cited by 4
Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes
Bondarenko, V., Chen, Q., Tillman, T. S., Xu, Y., & Tang, P. S. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00138 · Cited by 4
La participación de los receptores de acetilcolina nicotínicos en trastornos del Sistema Nervioso Central
López-Valdés, H. E., & García‐Colunga, J. (2003) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 4
Conformational analysis of 2-substituted piperazines
Kallel, E. A., Vangel, C., & Elbaum, D. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.05.022 · Cited by 4
Prevalence and predictors of treatment-resistant schizophrenia in a tertiary hospital from northeast Brazil
Soares, D. D. S., Carvalho, D. R., Ribeiro, M. D. T., Diniz, E., & Neto, A. F. R. (2021) · Trends in Psychiatry and Psychotherapy · doi:10.47626/2237-6089-2020-0151 · Cited by 7
An α7 nAChR approach for the baseline-dependent modulation of deviance detection in schizophrenia: A pilot study assessing the combined effect of CDP-choline and galantamine
Choueiry, J., Blais, C. M., Shah, D. K., Smith, D., Fisher, D. J., Labelle, A., & Knott, V. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231158903 · Cited by 4
Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech
Pradhan, A., Mounford, H., Peixinho, J., Rea, E., Epeslidou, E., Scott, J. S., Cull, J., Maxwell, S., Webster, R. G., Beeson, D., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05149-8 · Cited by 4
Preclinical Aspects of Nicotinic Acetylcholine Receptor Imaging
Brust, P., Deuther‐Conrad, W., Donat, C. K., Barthel, H., Riss, P. J., Paterson, L. M., Hoepping, A., Sabri, O., & Cumming, P. D. (2014) · Springer eBooks · doi:10.1007/978-3-642-42014-6_17 · Cited by 4
Human Brain Imaging of Acetylcholine Receptors
Toyohara, J., Sakata, M., & Ishiwata, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418677-4.00006-3 · Cited by 4
Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats
Ouach, A., Vercouillie, J., Bertrand, E., Rodrigues, N., Pin, F., Sérrière, S., Boiaryna, L., Chartier, A., Percina, N., Tangpong, P., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.06.049 · Cited by 4
Nicotine Ameliorates Emotional and Cognitive Impairments Induced byNeonatal PolyI:C Treatment in Mice
Yu, J., Nagai, T., Ibi, D., Kitahara, Y., Nabeshima, T., & Yamada, K. (2010) · The Open Behavioral Science Journal · Cited by 4
Smoking and Schizophrenia: Prevalence, Mechanisms and Implications for Treatment
Cather, C., Barr, R. S., & Evins, A. E. (2008) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.2.1.5 · Cited by 4
Racemic synthesis of 2′‐substituted nicotine analogs
Rouchaud, A., & Kem, W. R. (2011) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.841 · Cited by 4
Current progress in schizophrenia research: sensory gating deficit in schizophrenia: is the nicotinic alpha-7 receptor implicated?
Thaker, G. K. (2002) · PubMed · doi:10.1097/01.nmd.0000027590.27232.ed · Cited by 4
Pamoplantar Pustulosis. Pathogenetic Studies with Special Reference to the Role of Nicotine
Hagforsen, E. (2001) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 4
Real-time tilting and twisting motions of ligand-bound states of α7 nicotinic acetylcholine receptor
Yue, Y., Arai, T., Sasaki, D., Kuramochi, M., Inagaki, H., Ohashi, S., Sekiguchi, H., Mio, K., Kubo, T., & Sasaki, Y. C. (2024) · European Biophysics Journal · doi:10.1007/s00249-023-01693-6 · Cited by 3
Nicotinic acetylcholine receptors in the brain
Barrantes, F. J. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19088-9.00004-4 · Cited by 3
α7 nicotinic acetylcholine receptor, activated glia, and cognitive impairment in schizophrenia: a dual-tracer PET study
Wakuda, T., Yokokura, M., Magata, Y., Suzuki, C., Murayama, C., Goto, T., Tamayama, T., Kameno, Y., Iwabuchi, T., Isobe, T., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03162-2 · Cited by 3
Affinity purification of a chimeric nicotinic acetylcholine receptor in the agonist and antagonist bound states
Liu, S., Babcock, M. S., Bode, J., Chang, J. S., Fischer, H., Garlick, R. L., Gill, G. S., Lund, E. T., Margolis, B. J., Mathews, W. R., et al. (2011) · Protein Expression and Purification · doi:10.1016/j.pep.2011.05.019 · Cited by 3
Evaluation of the 20-Year Restoration Process in an Air-Pollution-Damaged Forest near the Ulsan Industrial Complex, Korea
Kim, D.-U., Lim, B. S., Seok, J.-E., Kim, G. S., Moon, J. S., Lim, C. H., & Lee, C. S. (2023) · Forests · doi:10.3390/f14081565 · Cited by 3
Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum
Schulz, J., Brandl, F., Grothe, M. J., Kirschner, M., Kaiser, S., Schmidt, A., Borgwardt, S., Priller, J., Sorg, C., & Avram, M. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad118 · Cited by 5
Cholinergic denervation attenuates phencyclidine-induced c-fos responses in rat cortical neurons
Savage, S., Mattsson, A., & Olson, L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.064 · Cited by 3
Nicotine Dependence and Schizophrenia
Basu, A., & Ray, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00025-0 · Cited by 3
Lobeline
Beach, W., Miller, R., & McCurdy, C. R. (1999) · CRC Press eBooks · doi:10.1201/9781420048650.ch11 · Cited by 3
Nicotine Dependence in Schizophrenia: Prevalence, Mechanisms, and Implications for Treatment
Evins, A. E. (2008) · Cited by 3
Nicotinic Acetylcholine Receptors are Possible Therapeutic Targets for Schizophrenia
Kohnomi, S., Suemaru, K., Kawasaki, H., Choshi, T., Hibino, S., & Araki, H. (2009) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.129.197 · Cited by 3
Beneficial Effect of Galantamine on Sensory Information-processing Deficits
Ago, Y. (2010) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.130.1305 · Cited by 3
The neurobiology of schizophrenia
Konopaske, G. T., & Coyle, J. T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00056-3 · Cited by 3
What is the Promise of Nicotinergic Compounds in Schizophrenia Treatment?
Mueller, J. K., Rohleder, C., & Leweke, F. M. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0154 · Cited by 3
CURRENT PROGRESS IN SCHIZOPHRENIA RESEARCH
Thaker, G. K. (2002) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200208000-00009 · Cited by 3
Dual cholinergic modulation in dementia: Quinuclidine carbamates targeting butyrylcholinesterase and α7 nicotinic receptor
Mastnak-Sokolov, P., Knez, D., Meden, A., Benedik, N. S., Benetik, S. F., Rambaher, M. H., Zorman, M., Nachon, F., Brazzolotto, X., Jardemark, K. E., et al. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111830 · Cited by 3
Chaperoning a7 neuronal nicotinic acetylcholine receptors
Vallés, A. S., & Barrantes, F. J. (2012) · CONICET Digital (CONICET) · Cited by 2
Nicotinic acetylcholine receptors (nACh) in GtoPdb v.2023.3
Gotti, C., Marks, M. J., Millar, N. S., & Wonnacott, S. (2023) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f76/2023.3 · Cited by 2
Nicotine: A Possible Neuroprotector in Brain Disorders
Alkadhi, K. A., Salim, S., & Alzoubi, K. H. (2025) · Springer eBooks · doi:10.1007/978-3-642-36202-6_178-1 · Cited by 2
Pharmacological approaches to cognitive enhancement
Harvey, P. D. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139003872.016 · Cited by 2
Methyllycaconitine Fails to Inhibit Electrically Precipitated Tonic Hindlimb Extension in Mice
Deutsch, S. I., Rosse, R. B., Bellack, A. S., Billingslea, E. N., & Mastropaolo, J. P. (2003) · Clinical Neuropharmacology · doi:10.1097/00002826-200303000-00004 · Cited by 2
Do Acetylcholinesterase Inhibitors Have a Role in Improving Cognitive Impairment in Patients with Schizophrenia?
Lenzi, A., & Tuscano, D. (2004) · International Journal of Pharmaceutical Medicine · doi:10.1097/00124363-200418030-00002 · Cited by 2
Translating Neurobiology to the Treatment of Dual Diagnosis: The Example of Nicotinic Receptors and Neurocognitive Endophenotypes in Schizophrenia
Bridgman, A. C., Mackowick, K. M., Goodman, M. S., Rabin, R. A., Barr, M. S., & George, T. P. (2014) · Current Addiction Reports · doi:10.1007/s40429-014-0033-8 · Cited by 2
Effects of Smoking on Hormones, Brain, and Behavior
Sidhartha, T., Poland, R. E., & Rao, U. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00108-x · Cited by 2
Acetylcholine Imaging in Psychosis
Vingerhoets, C., Booij, J., & van Amelsvoort, T. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_15 · Cited by 2
Genetic Regulation of Nicotine-Related Behaviors and Brain Nicotinic Receptors
Stitzel, J. A., Leonard, S. S., & Collins, A. C. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57079-7_22 · Cited by 2
Self-citation
The Cholinergic Hypothesis: An Introduction to the Hypothesis and a Short History
Friedman, J. I., Kanellopoulou, I., & Novakovic, V. (2012) · doi:10.1002/9781118309421.ch11 · Cited by 2
CholinergicAxonsModulateGABAergicSignaling amongHippocampalInterneuronsviaPostsynaptic7 NicotinicReceptors
Walker, M. (2007) · Cited by 2
Nicotinic Receptors and Mental Illness
Leonard, S. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1167-7_20 · Cited by 1
Self-citation
Eye movements and schizophrenia risk genes. Associations of the putative schizophrenia risk genes COMT and NRG-1 with smooth pursuit and antisaccade eye movement endophenotypes in schizophrenia patients and healthy controls drawn from the homogenous Icelandic population
Haraldsson, M. H. (2010) · Cited by 1
Nicotinic Acetylcholine Receptor Modulators
Mazurov, A. A., & Yohannes, D. (2014) · Topics in medicinal chemistry · doi:10.1007/7355_2014_56 · Cited by 1
In Situ/Histological Approaches to Neurotransmitter-Specific Postmortem Brain Studies of Schizophrenia
Bachus, S. E., & Kleinman, J. E. (2002) · Neurobiological foundation of aberrant behaviors · doi:10.1007/978-1-4757-3631-1_11 · Cited by 1

Authors: Freedman, R., Hall, M., Adler, L. E., & Leonard, S.
Affiliations: Denver VA Medical Center (US)
University of Colorado Denver (US)
Corresponding author: Freedman, Robert
ORCID: Freedman, Robert
Hall, Michael
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1995-07
Volume: 38
Issue: 1
Pages: 22-33
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/0006-3223(94)00252-x
OpenAlex: W2090019512
Cited by: 678
References: 55
Citations by year: 2026: 2 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 11 · 2021: 16 · 2020: 18 · 2019: 17 · 2018: 11 · 2017: 17 · 2016: 18 · 2015: 34 · 2014: 29 · 2013: 27 · 2012: 30
FWCI: 3.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1k01mh000728-01a1)
National Institute of Mental Health (MH-44212, MH00728, MH 38321, P50MH044212)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: schizophrenia, nicotinic acetylcholine receptors, hippocampus, alpha-bungarotoxin binding, auditory gating, inhibitory interneurons, dentate gyrus, CA3 region, postmortem brain, cholinergic dysfunction
MeSH terms: Quinolizidine Alkaloids, Adult, Aged, Alkaloids, Autoradiography, Azocines, Binding Sites, Bungarotoxins, Cell Count, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Quinolizines, Receptors, Nicotinic, Schizophrenia, Cholinergic Agents, Dentate Gyrus, Culture Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks