The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.
Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia
Abstract
This study tests the hypothesis that nicotinic cholinergic receptors, including those sensitive to the antagonist alpha-bungarotoxin, are decreased in the hippocampus of schizophrenics. The hypothesis is derived from the finding that alpha-bungarotoxin causes a defect in the inhibitory gating of auditory-evoked potentials in laboratory animals that resembles a defect in auditory sensory gating observed in schizophrenics. Nicotine transiently normalizes this psychophysiological deficit in schizophrenic patients. Postmortem brain tissue was obtained from eight schizophrenic and eight age-matched nonschizophrenic subjects. Sections of the hippocampus were labeled with [125I alpha-bungarotoxin and imagined by autoradiography. Binding of the nicotinic agonist [3H]-cytisine was determined in tissue homogenates. alpha-Bungarotoxin labeled a population of putative interneurons in the hippocampus, primarily in the dentate gyrus and the CA3 region of Ammon's horn. This labeling was significantly decreased in the tissue from the schizophrenic patients, with seven or eight patients below the range of the nonschizophrenic subjects. There was also a significant decrease in the binding of cytisine. The results were not related to generalized hippocampal cell loss, drug exposure at time of death, or smoking history. This initial study suggests that schizophrenic patients have fewer nicotinic receptors in the hippocampus, a condition which may lead to failure of cholinergic activation of inhibitory interneurons, manifest clinically as decreased gating of response to sensory stimulation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Thus, there is convergence between the genetic findings and the neurobiological model, corroborated by postmortem findings of decreased α7-nicotinic receptors in schizophrenia (31).”
From Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia (2015) · cites this paper as [31]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Progress in experimental personality research
Maher, W. B., & Maher, B. A. (1964) · Academic Press eBooks · Cited by 2,347
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471
Adler, L. E., Pachtman, E., Franks, R. D., Pecevich, M., Waldo, M. C., & Freedman, R. (1982) · PubMed · Cited by 896
Self-citationBenes, F. M. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810350036005 · Cited by 891
Bogerts, B. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790310046006 · Cited by 880
Flores, C. M., Rogers, S. W., Pabreza, L. A., Wolfe, B. B., & Kellar, K. J. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08832-7 · Cited by 880
Cigarette smoking: implications for psychiatric illness
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.4.546 · Cited by 723
Normalization of auditory physiology by cigarette smoking in schizophrenic patients
Adler, L. E., Hoffer, L., Wiser, A., & Freedman, R. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.12.1856 · Cited by 679
Self-citationCigarette smoking in schizophrenia: relationship to psychopathology and medication side effects
GOFF, D. C., Henderson, D. C., & Amico, E. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.9.1189 · Cited by 576
Research works printed but not linked: 3
- Daviss, 1993, Calbindin- and calretinin-immunoreactive local circuit neurons are increased in density in the prefrontal cortex of schizophrenic subjects, Neurosci Abstracts, 19, 201
- Goff, 1980, Neural origins of long latency evoked potentials recorded from the depth and from the cortical surface of the brain in man, Prog Clin Neurophysiol, 7, 126
- Klein, 1991, On the influence of smoking upon smooth pursuit eye movements of schizophrenics and normal controls, J Psychophysiology, 5, 361
Cited by
Sorted by citations
Items 301–400 of 690
Nicotine blocks quinpirole-induced behavior in rats: psychiatric implications
Tizabi, Y., Copeland, R., Brus, R., & Kostrzewa, R. M. (1999) · Psychopharmacology · doi:10.1007/s002130051078 · Cited by 39
Stryjer, R., Strous, R. D., Bar, F., Shaked, G., Shiloh, R., Rozencwaig, S., Grupper, D., Buchman, N., Kotler, M., Rabey, J. M., et al. (2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.595 · Cited by 39
Mastropaolo, J. P., Rosse, R. B., & Deutsch, S. I. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.023 · Cited by 39
Simplified quantification of nicotinic receptors with 2[18F]F-A-85380 PET
Mitkovski, S., Villemagne, V. L., Novakovic, K. E., O'Keefe, G. J., Tochon‐Danguy, H., Mulligan, R. S., Dickinson, K. L., Saunder, T., Grégoire, M., Bottlaender, M., et al. (2005) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2005.04.013 · Cited by 39
Lewis, A. S., & Picciotto, M. R. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3126-5 · Cited by 38
Pharmacological Strategies for Enhancing Cognition in Schizophrenia
Barch, D. M. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_39 · Cited by 38
Carson, R., Craig, D., Hart, D. J., Todd, S., McGuinness, B., Johnston, J. A., O’Neill, F. A., Ritchie, C. W., & Passmore, A. P. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8048-8 · Cited by 38
Maloku, E., Kadriu, B., Zhubi, A., Dong, E., Pibiri, F., Satta, R., & Guidotti, A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.21 · Cited by 38
Bakanidze, G., Roinishvili, M., Chkonia, E. D., Kitzrow, W., Richter, S., Neumann, K., Herzog, M. H., Brand, A., & Puls, I. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00133 · Cited by 39
Haig, G. M., Wang, D., Othman, A. A., & Zhao, J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.101 · Cited by 38
Dean, B., Opeskin, K., Pavey, G., Hill, C., & Keks, N. A. (1997) · Journal of Neural Transmission · doi:10.1007/bf01294738 · Cited by 38
Horti, A. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.030 · Cited by 33
Vingerhoets, W. A. M., Bloemen, O., Bakker, G., & van Amelsvoort, T. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00157 · Cited by 39
Coughlin, J. M., Du, Y., Rosenthal, H. B., Slania, S., Koo, S. M., Park, A., Solomon, G., Vranešić, M., Antonsdottir, I. M., Speck, C. L., et al. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.10.009 · Cited by 37
Imaging Habenula Volume in Schizophrenia and Bipolar Disorder
Schafer, M., Kim, J.-W., Joseph, J., Xu, J., Frangou, S., & Doucet, G. E. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00456 · Cited by 36
Chaperoning α7 neuronal nicotinic acetylcholine receptors.
Vallés, A. S., & Barrantes, F. (2012) · Biochimica et Biophysica Acta · doi:10.1016/j.bbamem.2011.10.012 · Cited by 35
Effects of Rivastigmine on Sustained Attention in Schizophrenia
Aasen, I., Kumari, V., & Sharma, T. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000169267.36797.76 · Cited by 37
Vallés, A. S., & Barrantes, F. J. (2023) · Cells · doi:10.3390/cells12162051 · Cited by 37
Assessment of the effects of AZD3480 on cognitive function in patients with schizophrenia
Velligan, D. I., Brenner, R., Sicuro, F., Walling, D. P., Riesenberg, R. A., Sfera, A., Merideth, C., Sweitzer, D. E., & Jaeger, J. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.10.004 · Cited by 36
Deuther-Conrad, W., Fischer, S., Hiller, A., Becker, G., Cumming, P., Xiong, G., Funke, U., Sabri, O., Peters, D., & Brust, P. (2011) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-011-1808-y · Cited by 35
Autism - A Neurodevelopmental Journey from Genes to Behaviour
Eapen, V. (2011) · InTech eBooks · doi:10.5772/974 · Cited by 36
Knott, V., McIntosh, J. F., Millar, A., Fisher, D. J., Villeneuve, C. M., Ilivitsky, V., & Horn, E. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.08.005 · Cited by 36
Increased antibodies for the α7 subunit of the nicotinic receptor in schizophrenia
Chandley, M., Miller, M. N., Kwasigroch, C. N., Wilson, T. D., & Miller, B. E. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.01.023 · Cited by 36
Dopamine D2 agonist priming in intact and dopamine-lesioned rats
Kostrzewa, R. M., Kostrzewa, J. P., Nowak, P. G., Kostrzewa, R. A., & Brus, R. (2004) · Neurotoxicity Research · doi:10.1007/bf03033281 · Cited by 37
Nicotinic-antipsychotic drug interactions and cognitive function
Levin, E. D., & Rezvani, A. H. (2006) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7772-4_10 · Cited by 36
Cognitive enhancing agents in schizophrenia and bipolar disorder
Vreeker, A., van Bergen, A. H., & Kahn, R. S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.014 · Cited by 37
Knott, V., de la Salle, S., Smith, D., Phillipe, T., Dort, H., Choueiry, J., & Impey, D. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113490449 · Cited by 35
Altered hippocampal circuit function in C3H α7 null mutant heterozygous mice
Adams, C. E., Yonchek, J. C., Zheng, L., Collins, A. C., & Stevens, K. E. (2008) · Brain Research · doi:10.1016/j.brainres.2007.12.007 · Cited by 35
Werkheiser, J. L., Sydserff, S. G., Hubbs, S. J., Ding, M., Eisman, M. S., Perry, D., Williams, A., Smith, J. S., Mrzljak, L., & Maier, D. L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.033 · Cited by 35
Lascio, S. D., Fornasari, D., & Benfante, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073463 · Cited by 35
The Effects of Galantamine on Psychopathology in Chronic Stable Schizophrenia
Conley, R. R., Boggs, D. L., Kelly, D. L., McMahon, R. P., Dickinson, D., Feldman, S. M., Ball, M. P., & Buchanan, R. W. (2008) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e31816f2795 · Cited by 35
Pocivavsek, A., Icenogle, L., & Levin, E. D. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0416-1 · Cited by 35
Cannon, C. E., Puri, V., Vivian, J. A., Egbertson, M. S., Eddins, D. M., & Uslaner, J. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.003 · Cited by 33
iPSC model of CHRFAM7A effect on α7 nicotinic acetylcholine receptor function in the human context
Ihnatovych, I., Nayak, T. K., Ouf, A., Süle, N., Birkaya, B. G., Chaves, L. D., Auerbach, A. L., & Szigeti, K. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0375-z · Cited by 34
Lower cholinergic basal forebrain volumes link with cognitive difficulties in schizophrenia
Avram, M., Grothe, M. J., Meinhold, L., Leucht, C., Leucht, S., Borgwardt, S., Brandl, F., & Sorg, C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01070-x · Cited by 35
Feuerbach, D., Pezous, N., Weiss, M., Shakeri-Nejad, K., Lingenhoehl, K., Hoyer, D., Hurth, K., Bilbe, G., Pryce, C., McAllister, K., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13001 · Cited by 32
First Administration of Cytidine Diphosphocholine and Galantamine in Schizophrenia
Deutsch, S. I., Schwartz, B. L., Schooler, N. R., Rosse, R. B., Mastropaolo, J. P., & Gaskins, B. L. (2008) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e31806462ba · Cited by 34
Toyohara, J., Ishiwata, K., Sakata, M., Wu, J., Nishiyama, S., Tsukada, H., & Hashimoto, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008961 · Cited by 34
Knott, V., Millar, A., Fisher, D. J., & Albert, P. R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.053 · Cited by 34
Physostigmine and cognition in schizotypal personality disorder
Kirrane, R., Mitropoulou, V., Nunn, M., Silverman, J. M., & Siever, L. J. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00059-1 · Cited by 34
McLean, S. L., Grayson, B., Marsh, S., Zarroug, S. H. O., Harte, M., & Neill, J. C. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.08.037 · Cited by 33
Neuronal α7 Nicotinic Receptors as a Target for the Treatment of Schizophrenia
Wallace, T. L., & Bertrand, D. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.08.003 · Cited by 37
Hu, Y. C., Fang, Z., Yang, Y., Rohlsen-Neal, D., Cheng, F., & Wang, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-21297-x · Cited by 34
Mazeh, D., Zemishlani, H., Barak, Y., Mirecki, I., & Paleacu, D. (2006) · International Psychogeriatrics · doi:10.1017/s1041610205003017 · Cited by 33
Chronic nicotine interactions with clozapine and risperidone and attentional function in rats
Rezvani, A. H., Caldwell, D. P., & Levin, E. D. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.10.017 · Cited by 33
́, Z. K., Šťastný, F., Bubeníková, V., Druga, R., Klaschka, J., & Španiel, F. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000018837.27383.ff · Cited by 33
André, J. M., Leach, P. T., & Gould, T. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.004 · Cited by 32
Sakata, M., Wu, J., Toyohara, J., Oda, K., Ishikawa, M., Ishii, K., Hashimoto, K., & Ishiwata, K. (2010) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2010.09.007 · Cited by 32
Molecular alterations in the medial temporal lobe in schizophrenia
Bobilev, A. M., Perez, J. M., & Tamminga, C. A. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.06.001 · Cited by 34
Ion Channel Diseases of the Central Nervous System
Li, M., & Lester, H. A. (2001) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2001.tb00196.x · Cited by 30
Petrovsky, N., Ettinger, U., Quednow, B. B., Walter, H., Schnell, K., Kessler, H., Mößner, R., Maier, W., & Wagner, M. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2540-9 · Cited by 31
Kohnomi, S., Suemaru, K., Goda, M., Choshi, T., Hibino, S., Kawasaki, H., & Araki, H. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.037 · Cited by 31
Pharmacological Approaches to the Management of Cognitive Dysfunction in Schizophrenia
Harvey, P. D., & McClure, M. M. (2006) · Drugs · doi:10.2165/00003495-200666110-00004 · Cited by 31
Input dysfunction, schizotypy, and genetic models of schizophrenia
Freedman, R., Adler, L. E., D, A. O. M., Waldo, M. C., Ross, R. G., Stevens, K. E., & Leonard, S. S. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00348-6 · Cited by 31
Self-citationModulation of α7 Nicotinic Receptor-Mediated Calcium Influx by Nicotinic Agonists
Quik, M., Philie, J., & Choremis, J. (1997) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13492-x · Cited by 58
R-(+) and S-(−) Isomers of Cotinine Augment Cholinergic Responses In Vitro and In Vivo
Terry, A. V., Callahan, P. M., & Bertrand, D. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.219881 · Cited by 30
Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia
Stephens, S. H., Franks, A. L., Berger, R., Palionyte, M., Fingerlin, T. E., Wagner, B. D., Logel, J., D, A. O. M., Ross, R. G., Freedman, R., et al. (2011) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32834c0c33 · Cited by 30
Self-citationStimulation of the α4β2 nicotinic receptor by 5-I A-85380 improves auditory gating in DBA/2 mice
Wildeboer, K. M., & Stevens, K. E. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.007 · Cited by 30
Zhang, W., Ross, P. J., Ellis, J., & Salter, M. W. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02010-z · Cited by 36
Sinha, N., Karche, N. P., Verma, M. K., Walunj, S. S., Nigade, P. B., Jana, G., Kurhade, S. P., Hajare, A. K., Tilekar, A. R., Jadhav, G. R., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01569 · Cited by 30
Gargus, M., Ben‐Azu, B., Landwehr, A., Dunn, J., Errico, J. P., & Tremblay, M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1527842 · Cited by 32
Koola, M., Looney, S., Hong, H.-L., Pillai, A., & Hou, W. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113285 · Cited by 22
Prenatal choline and the development of schizophrenia.
Freedman, R., & Ross, R. G. (2015) · Europe PMC (PubMed Central) · doi:10.11919/j.issn.1002-0829.215006 · Cited by 29
Self-citationTracy, H. A., Wayner, M. J., & Armstrong, D. L. (1999) · Alcohol · doi:10.1016/s0741-8329(98)00074-3 · Cited by 29
Smucny, J., Stevens, K. E., Olincy, A., & Tregellas, J. R. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.77 · Cited by 28
Cholinergic system in schizophrenia: A systematic review and meta-analysis
Saint-Georges, Z., MacDonald, J., Al-Khalili, R., Hamati, R., Solmi, M., Keshavan, M. S., Tuominen, L. J., & Guimond, S. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03023-y · Cited by 32
Mitra, S., Mucha, M., Khatri, S., Glenon, R., Schulte, M. K., & Bult‐Ito, A. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00244 · Cited by 32
Sensory Gating in Patients With Alzheimer’s Disease and Their Biological Children
Ally, B. A., Jones, G. E., Cole, J. A., & Budson, A. E. (2007) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317506292282 · Cited by 28
Thomsen, M. S., Mikkelsen, J. D., Timmermann, D. B., Peters, D., Hay‐Schmidt, A., Martens, H., & Hansen, H. H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.083 · Cited by 28
Coughlin, J. M., Du, Y., Crawford, J. L., Rubin, L. H., Azad, B. B., Lesniak, W. G., Horti, A. G., Schretlen, D. J., Sawa, A., & Pomper, M. G. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.213686 · Cited by 28
Mendelsohn, E., Rosenthal, M., Bohiri, Y., Werber, E. A., Kotler, M., & Strous, R. D. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200411000-00001 · Cited by 28
Adams, C. E., Stevens, K. E., Kem, W. R., & Freedman, R. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02677-9 · Cited by 28
Self-citationMok, M. H. S., & Kew, J. N. C. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.104794 · Cited by 28
Knott, V., Smith, D., de la Salle, S., Impey, D., Choueiry, J., Beaudry, E., Smith, M. K., Saghir, S., Ilivitsky, V., & Labelle, A. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114553254 · Cited by 27
Tanibuchi, Y., Wu, J., Toyohara, J., Fujita, Y., Iyo, M., & Hashimoto, K. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.008 · Cited by 27
Altered neural oscillations and behavior in a genetic mouse model of NMDA receptor hypofunction
Aguilar, D. D., Radzik, L. K., Schiffino, F. L., Folorunso, O. O., Zielinski, M. R., Coyle, J. T., Balu, D. T., & McNally, J. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-88428-9 · Cited by 27
Chung, Y., Lee, C.-R., Park, T.-W., Yang, K.-H., & Kim, K. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701432551 · Cited by 27
Stoichiometry for drug potentiation of a pentameric ion channel
daCosta, C. J. B., & Sine, S. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301909110 · Cited by 27
Chapter 5. Targeting nicotinic acetylcholine receptors: Advances in molecular design and therapies
Schmitt, J. D., & Bencherif, M. (2000) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(00)35006-0 · Cited by 27
Boggs, D. L., Carlson, J., Cortes-Briones, J., Krystal, J. H., & D’Souza, D. C. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612819666131216121019 · Cited by 26
Stevens, K. E., Choo, K. S., Stitzel, J. A., Marks, M. J., & Adams, C. E. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.022 · Cited by 26
Friis, S., Mathes, C., Sunesen, M., Bowlby, M., & Dunlop, J. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.10.007 · Cited by 31
Smucny, J., Visani, A. V., & Tregellas, J. R. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00043 · Cited by 28
Hellier, J. L., Arevalo, N. L., Blatner, M. J., Dang, A. K., Clevenger, A. C., Adams, C. E., & Restrepo, D. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.027 · Cited by 26
Knott, V., Impey, D., Choueiry, J., Smith, D., de la Salle, S., Saghir, S., Smith, M. K., Beaudry, E., Ilivitsky, V., & Labelle, A. (2015) · Neuropsychiatric Electrophysiology · doi:10.1186/s40810-014-0002-4 · Cited by 26
Severance, E. G., & Yolken, R. H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.008 · Cited by 25
Characterization of allelic variants at chromosome 15q14 in schizophrenia
Freedman, R., Leonard, S. S., Waldo, M., Gault, J., D, A. O. M., & Adler, L. E. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00190.x · Cited by 26
Self-citationDepression, smoking, and nicotine: Toward a bioinformational situation by trait model
Gilbert, D. G. (1996) · Drug Development Research · doi:10.1002/(sici)1098-2299(199607/08)38:3/4 · Cited by 25
Esaki, H., Izumi, S., Fukao, A., Ito, S., Nishitani, N., Deyama, S., & Kaneda, K. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00314 · Cited by 25
Freedman, R., & Goldowitz, D. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.008 · Cited by 25
Self-citationBouvrais‐Veret, C., Weiss, S., Andrieux, A., Schweitzer, A., McIntosh, J. M., Job, D., Giros, B., & Martres, M. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.03.015 · Cited by 32
In Search of Allosteric Modulators of α7-nAChR by Solvent Density Guided Virtual Screening
Dey, R., & Chen, L. (2011) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2011.10508600 · Cited by 25
Treating Schizophrenia: Novel Targets for the Cholinergic System
Money, T., Scarr, E., Udawela, M., Gibbons, A. S., Jeon, W. J., Seo, M. S., & Dean, B. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791012062 · Cited by 24
Saur, T., DeMarco, S., Ortiz, A., Sliwoski, G. R., Hao, L., Wang, X., Cohen, B. M., & Buttner, E. A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003313 · Cited by 25
Dentate Gyrus Immaturity in Schizophrenia
Tavitian, A., Song, W., & Schipper, H. M. (2019) · The Neuroscientist · doi:10.1177/1073858418824072 · Cited by 23
Othman, A. A., Lenz, R. A., Zhang, J., Li, J., Awni, W. M., & Dutta, S. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270010370460 · Cited by 24
Meta-analyses of 10 polymorphisms associated with the risk of schizophrenia
Dai, D., Wang, Y., Yuan, J., Zhou, X., Jiang, D., Li, J., Zhang, Y., Yin, H., & Duan, S. (2014) · Biomedical Reports · doi:10.3892/br.2014.308 · Cited by 24
Søderman, A., Thomsen, M. S., Hansen, H. H., Nielsen, E. Ø., Jensen, M. S., West, M. J., & Mikkelsen, J. D. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.062 · Cited by 24
Ancín, I., Barabash, A., Vázquez-Álvarez, B., Santos, J. L., Sánchez‐Morla, E. M., Martínez, J. L., Aparicio, A. I., Peláez, J. C., & Díaz, J. A. C. (2010) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32833a9b7a · Cited by 24
Tobacco addiction: A biochemical model of nicotine dependence
Ortells, M. O., & Barrantes, G. E. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.11.004 · Cited by 26
Metadata
- Authors
- Freedman, R., Hall, M., Adler, L. E., & Leonard, S.
- Affiliations
- Denver VA Medical Center (US)
- University of Colorado Denver (US)
- Corresponding author
- Freedman, Robert
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 38
- Issue
- 1
- Pages
- 22-33
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2090019512
- Cited by
- 678
- References
- 55
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 11 · 2021: 16 · 2020: 18 · 2019: 17 · 2018: 11 · 2017: 17 · 2016: 18 · 2015: 34 · 2014: 29 · 2013: 27 · 2012: 30
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1k01mh000728-01a1)
- National Institute of Mental Health (MH-44212, MH00728, MH 38321, P50MH044212)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- schizophrenia, nicotinic acetylcholine receptors, hippocampus, alpha-bungarotoxin binding, auditory gating, inhibitory interneurons, dentate gyrus, CA3 region, postmortem brain, cholinergic dysfunction
- MeSH terms
- Quinolizidine Alkaloids, Adult, Aged, Alkaloids, Autoradiography, Azocines, Binding Sites, Bungarotoxins, Cell Count, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Quinolizines, Receptors, Nicotinic, Schizophrenia, Cholinergic Agents, Dentate Gyrus, Culture Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
