The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophrenia
Abstract
Circadian rhythm abnormalities have been described mostly with respect to manic-depressive illness; little information is available concerning circadian rhythms and schizophrenia or their influence on neuroleptic drugs. We showed previously that the MESOR of dopamine is higher in schizophrenic patients than in healthy subjects and that women who are drug-free schizophrenic have lower prolactin MESORs and lower amplitudes than healthy women. We now report the data of a cosinor analysis of tryptophan, serotonin, melatonin, and pituitary hormones in the blood of 34 healthy subjects, 90 drug-free schizophrenics, and 25 neuroleptic-treated schizophrenic patients. This data indicated a significant phase advance of serum tryptophan, prolactin, and melatonin concentrations, a trend toward a phase advance in serotonin. Thyroid stimulating hormone (TSH), and growth hormone concentrations, and decreases in the TSH MESORs among patients compared to healthy subjects. These results suggest that circadian changes, such as phase advances and alterations in MESOR, are not only present in depression but also in schizophrenia. Although neuroleptic treatment raised the prolactin MESOR and amplitude, it did not elicit any change in circadian rhythmicity among the other parameters.
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“Studies of individuals with SZ who were not currently taking medication have revealed alterations in several aspects of the melatonin rhythm, including reduced nighttime melatonin concentrations149–151, blunted rhythmic amplitude149,150, and phase advance of the typical melatonin acrophase152.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [152]
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“In contrast to melatonin, the cortisol circadian rhythm appears to remain more or less intact in SZ150–152, although concentrations are often elevated relative to healthy controls156,157.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [152]
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Cites
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- Fernstrom, 1988, Tryptophan availability and serotinin synthesis in brain, vol. 20, 201
- Kishimoto, 1977, The biochemical studies of manic-depressive psychosis: I. The circadian rhythm of plasma trypophan, tyrosine and cortisol, and its clinical significance, Yokohama Med Bull, 28, 23
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Circadian rhythm disruption and mental health
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030
Circadian misalignment and health
Baron, K. G., & Reid, K. J. (2014) · International Review of Psychiatry · doi:10.3109/09540261.2014.911149 · Cited by 645
Antipsychotic-Induced Hyperprolactinaemia: Mechanisms, Clinical Features and Management
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Peuskens, J., Pani, L., Detraux, J., & De Hert, M. (2014) · CNS Drugs · doi:10.1007/s40263-014-0157-3 · Cited by 350
Marx, W., McGuinness, A. J., Rocks, T., Ruusunen, A. A., Cleminson, J. R., Walker, A. J., Gomes‐da‐Costa, S., Lane, M. M., Sanches, M., Díaz, A. P., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00951-9 · Cited by 339
Metadata
- Authors
- Rao, M. L., Gross, G., Strebel, B., Halaris, A., Huber, G., Bräunig, P., & Marler, M.
- Affiliations
- University of Bonn (DE)
- University of Mississippi (US)
- Corresponding author
- Rao, Maria Luise
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1994-02
- Volume
- 35
- Issue
- 3
- Pages
- 151-163
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2172147562
- Cited by
- 154
- References
- 78
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 13 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 8
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- circadian rhythm, schizophrenia, tryptophan, serotonin, melatonin, prolactin, pituitary hormones, thyroid-stimulating hormone, growth hormone, antipsychotic drugs, mesor, phase advance, cosinor analysis
- MeSH terms
- Adolescent, Adult, Aged, Circadian Rhythm, Female, Humans, Hypothalamo-Hypophyseal System, Male, Melatonin, Middle Aged, Neural Inhibition, Pituitary Hormones, Prolactin, Reference Values, Schizophrenia, Schizophrenic Psychology, Serotonin, Growth Hormone, Thyrotropin, Antipsychotic Agents, Tryptophan
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