Uptake of corticosterone by rat brain and its concentration by certain limbic structures
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The hippocampus has the greatest density of glucocorticoid receptors of all brain structures.
“He and his coworkers first showed that the hippocampus has the greatest density of glucocorticoid receptors of all brain structures (McEwen et al. [122]; McEwen et al. [123])”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as McEwen et al. [122]
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Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580 · see citing works
The acute effects of corticosteroids on cognition: integration of animal and human model studies
LUPIEN, S., & MCEWEN, B. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00004-0 · Cited by 1,024 · see citing works
Self-citationDiamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762 · see citing works
“He and his coworkers first showed that the hippocampus has the greatest density of glucocorticoid receptors of all brain structures (McEwen et al. [122]; McEwen et al. [123]), indicating that the hippocampus was highly responsive to stressful experiences.”
BackgroundThe neuronal mineralocorticoid eeceptor as a mediator of glucocorticoid response
Arriza, J. L., Simerly, R. B., Swanson, L. W., & Evans, R. M. (1988) · Neuron · doi:10.1016/0896-6273(88)90136-5 · Cited by 591 · see citing works
Chronic Stress-induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis
Conrad, C. D. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.6.395 · Cited by 425 · see citing works
Glucocorticoid effects on object recognition memory require training-associated emotional arousal
Okuda, S., Roozendaal, B., & McGaugh, J. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307803100 · Cited by 402 · see citing works
Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., & Plotsky, P. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.007 · Cited by 368 · see citing works
Rat brain binds adrenal steroid hormone: Radioautography of hippocampus with corticosterone
Gerlach, J. L., & McEwen, B. S. (1972) · Science · doi:10.1126/science.175.4026.1133 · Cited by 306 · see citing works
Self-citationLupien, S. J., Nair, N. P. V., Briére, S., Maheu, F., Tu, M. T., Lemay, Μ., McEwen, B. S., & Meaney, M. J. (1999) · Reviews in the Neurosciences · doi:10.1515/revneuro.1999.10.2.117 · Cited by 283 · see citing works
Self-citationA selective role for corticosterone in contextual-fear conditioning
Pugh, C. R., Tremblay, D., Fleshner, M., & Rudy, J. W. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.3.503 · Cited by 272 · see citing works
DALLMAN, M. F., LEVIN, N., CASCIO, C. S., AKANA, S. F., JACOBSON, L., & KUHN, R. W. (1989) · Endocrinology · doi:10.1210/endo-124-6-2844 · Cited by 153 · see citing works
Relative binding affinity of steroids for the corticosterone receptor system in rat hippocampus
De Kloet, E. R., Veldhuis, H. D., Wagenaars, J. L., & Bergink, E. W. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90380-7 · Cited by 47 · see citing works
Gerecke, K. M., Kolobova, A., Allen, S., & Fawer, J. L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.027 · Cited by 37 · see citing works
- Authors
- McEwen, B. S., Weiss, J. M., & Schwartz, L. S.
- Affiliations
- Rockefeller University (US)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1969-11
- Volume
- 16
- Issue
- 1
- Pages
- 227-241
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2033506746
- Cited by
- 296
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 13.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- corticosterone, brain uptake, hippocampus, septum, limbic system, adrenalectomy, stress, cortisol, dexamethasone, ACTH release, glucocorticoid activity
- MeSH terms
- Adrenal Glands, Adrenalectomy, Amygdala, Animals, Brain, Brain Chemistry, Brain Stem, Cerebral Cortex, Cerebral Ventricles, Corticosterone, Hippocampus, Hypothalamus, Pituitary Gland, Time Factors, Tritium, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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