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Glucocorticoid effects on object recognition memory require training-associated emotional arousal

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Okuda, Shoki, Roozendaal, Benno, McGaugh, James L.·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0307803100PMC PMC321770
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Abstract

Considerable evidence implicates glucocorticoid hormones in the regulation of memory consolidation and memory retrieval. The present experiments investigated whether the influence of these hormones on memory depends on the level of emotional arousal induced by the training experience. We investigated this issue in male Sprague-Dawley rats by examining the effects of immediate posttraining systemic injections of the glucocorticoid corticosterone on object recognition memory under two conditions that differed in their training-associated emotional arousal. In rats that were not previously habituated to the experimental context, corticosterone (0.3, 1.0, or 3.0 mg/kg, s.c.) administered immediately after a 3-min training trial enhanced 24-hr retention performance in an inverted-U shaped dose-response relationship. In contrast, corticosterone did not affect 24-hr retention of rats that received extensive prior habituation to the experimental context and, thus, had decreased novelty-induced emotional arousal during training. Additionally, immediate posttraining administration of corticosterone to nonhabituated rats, in doses that enhanced 24-hr retention, impaired object recognition performance at a 1-hr retention interval whereas corticosterone administered after training to well-habituated rats did not impair 1-hr retention. Thus, the present findings suggest that training-induced emotional arousal may be essential for glucocorticoid effects on object recognition memory.

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  • Emotional arousal for a rodent by being placed in a novel environment is required for adrenal steroids to enhance object recognition memory, that involves the hippocampus; the effects of adrenal steroids on this memory show an inverted U shaped dose response.

    “Emotional arousal for a rodent by being placed in a novel environment is required for adrenal steroids to enhance object recognition memory, that involves the hippocampus; the effects of adrenal steroids on this memory show an inverted U shaped dose response (Okuda et al., 2004).”

    From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Okuda et al., 2004

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Authors
Okuda, S., Roozendaal, B., & McGaugh, J. L.
Affiliations
University of California, Irvine (US)
ORCID
Roozendaal, Benno
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2004-01-07
Volume
101
Issue
3
Pages
853-858
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0307803100
PMC
PMC321770
OpenAlex
W2015987039
Cited by
402
References
83
Citations by year
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FWCI
11.58
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service
  • National Institute of Mental Health (R01MH012526, MH12526, R56MH012526)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
glucocorticoids, corticosterone, object recognition memory, emotional arousal, memory consolidation, memory retrieval, habituation, dose-response relationship, retention interval, rats
MeSH terms
Animals, Arousal, Conditioning, Psychological, Corticosterone, Emotions, Glucocorticoids, Habituation, Psychophysiologic, Learning, Male, Memory, Rats, Sprague-Dawley, Rats

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