Cited by 272Memory and Neural MechanismsStress Responses and CortisolMemory Processes and Influences

A selective role for corticosterone in contextual-fear conditioning

Pugh, C. Rachal, Tremblay, Darren, Fleshner, Monika, Rudy, Jerry W.·1997·Behavioral Neuroscience

Abstract

The contribution of corticosterone to contextual- and auditory-cue fear conditioning was examined. Adrenalectomized rats showed reduced contextual-fear conditioning when tested 24 hr after conditioning; however, neither immediate contextual- nor auditory-cue fear conditioning was impaired. Contextual-fear conditioning in adrenalectomized rats with corticosterone replacement during the 4-day interval separating surgery and conditioning matched the level of controls. Moreover, rats exposed to the context prior to adrenalectomy showed normal long-term contextual-fear conditioning. Corticosterone replacement administered after the conditioning episode also negated the effects of adrenalectomy. Thus, corticosterone's role in fear conditioning is selective: It appears to contribute to the neural processes that support the consolidation of a long-term memory representation of the context.

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Crossref · 10.1037/0735-7044.111.3.503

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Authors
Pugh, C. R., Tremblay, D., Fleshner, M., & Rudy, J. W.
Affiliations
University of Colorado Boulder (US)
Venue
Behavioral Neuroscience
Published
1997-06
Volume
111
Issue
3
Pages
503-511
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
OpenAlex
W2057143757
Cited by
272
References
38
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 17 · 2013: 10 · 2012: 6
FWCI
5.67
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioral Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (5r01mh049407-03)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
corticosterone, contextual fear conditioning, adrenalectomy, corticosterone replacement, memory consolidation, long-term memory, glucocorticoids, rats
MeSH terms
Acoustic Stimulation, Adrenalectomy, Animals, Arousal, Association Learning, Conditioning, Classical, Corticosterone, Fear, Female, Male, Mental Recall, Retention, Psychology, Rats

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