The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.
Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): Half-times of disappearance of these neuropeptides from CSF
Abstract
The penetration of neurohypophyseal peptides after peripheral administration into the cerebrospinal fluid (CSF) was studied in freely moving rats. In addition, the clearance of these peptides from CSF was investigated. Increased concentrations of vasopressin (AVP) in CSF were detectable 2 min after s.c. injection of 5.0 micrograms of this peptide. Peak concentration was reached at 5 min after administration and this level declined slowly over the next hour. Administration of 5.0 micrograms oxytocin (OXT) s.c. or i.v. resulted in increased OXT levels in CSF within 10 min after application. After 60 min a significant elevation of OXT in CSF was no longer present. These data reveal that approximately 0.002% of the peripherally applied amount of AVP or OXT reached the central nervous system at 10 min after injection. AVP (2.5 ng) and OXT (5.0 ng) applied into one of the lateral brain ventricles reached the cisternal cavity within 2 min after administration. Both neuropeptides were cleared from the CSF with terminal half-times of 26 and 19 min for AVP and OXT, respectively. The present data demonstrate that neurohypophyseal hormones do cross the blood-brain barrier in amounts obviously sufficient to induce central actions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“After entering the blood, oxytocin rapidly penetrates extravascular fluid, but does not cross the blood-brain barrier in appreciable amounts.”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [10]
In the citing paper
“The effectiveness of the blood-brain barrier for oxytocin was measured by Mens et al., who injected 5µg subcutaneously in rats, increasing plasma concentrations 500-fold to ~38,600pg/ml (10).Increases in CSF were modest; concentrations increased from ~40pg/ml to ~150pg/ml.The authors calculated that just 0.002% of the injected oxytocin had reached the CNS after 10min, when CSF concentrations were”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [10]
In the citing paper
“although mixed evidence has been observed in humans.80”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [80]
Citations
Cites
Drugs and the Pharmaceutical Sciences
(2010) · Drugs and the pharmaceutical sciences · doi:10.1201/ihcdruphasci · Cited by 587
Behavioral effects of intraventricularly administered vasopressin and vasopressin fragments
de Wied, D. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90165-x · Cited by 359
Dogterom, J., Greidanus, T. B. V. W., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000122702 · Cited by 247
Entry of Opioid Peptides into the Central Nervous System
Рапопорт, С. И., Klee, W. A., Pettigrew, K. D., & Ohno, K. (1980) · Science · doi:10.1126/science.7350645 · Cited by 245
BOHUS, B., URBAN, I., VANWIMERSMAGREIDANUS, T., & DEWIED, D. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90107-7 · Cited by 231
Self-citationThe effects of ACTH- and vasopressin-analogues on CO2-induced retrograde amnesia in rats
Rigter, H., van Riezen, H., & de Wied, D. (1974) · Physiology & Behavior · doi:10.1016/0031-9384(74)90092-4 · Cited by 213
Intraventricular administration of anti-vasopressin serum inhibits memory consolidation in rats
Greidanus, T. B. V. W., Dogterom, J., & Wied, D. D. (1975) · Life Sciences · doi:10.1016/s0024-3205(75)80015-4 · Cited by 204
THE CEREBROSPINAL FLUID AS A PATHWAY IN NEUROENDOCRINE INTEGRATION
Rodríguez, E. M. (1976) · Journal of Endocrinology · doi:10.1677/joe.0.0710407 · Cited by 197
Vasopressin in cerebrospinal fluid and plasma of man, dog, and rat.
Dogterom, J., Greidanus, T. B. V. W., & de Wied, D. (1978) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1978.234.5.e463 · Cited by 157
Bass, N. H., & Lundborg, P. G. (1973) · Brain Research · doi:10.1016/0006-8993(73)90668-9 · Cited by 153
Research works printed but not linked: 3
- Jones, P. M. and Robinson, I. C. A. F., Differential clearance of neurophysin and neurohypophyseal peptides from the cerebrospinal fluid in conscious guinea pigs,Neuroendocrinology, in press.
- Kozlowski, 1976, Neurosecretory pathways to the choroid plexus, IRC Med. Sci., 4, 299
- van Wimersma Greidanus, 1978, Behavioral changes of rats after neutralization of central available neuropeptides by administration of specific antisera, Vol. 88, 192
Cited by
Sorted by citations
Items 301–357 of 357
Effect of service and oxytocin on estrus duration in goats
Romano, J. E. (1997) · Small Ruminant Research · doi:10.1016/s0921-4488(96)00908-x · Cited by 3
Oliveira, P., Soares, M. C., & Trigo, S. (2024) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105646 · Cited by 4
Nasal dominance potentiates intranasal oxytocin’s anxiolytic effects
Julius, N., Nicholls, D., Nowell, J., & Burmester, V. (2025) · Scientific Reports · doi:10.1038/s41598-025-95148-x · Cited by 3
Thakur, P., Shrivastava, R., & Shrivastava, V. K. (2021) · Metabolism Open · doi:10.1016/j.metop.2021.100146 · Cited by 2
The role of vasopressin in behaviors associated with aversive stimuli
(2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80015-x · Cited by 2
Koehler-Stec, E. M., Byers, A. L., & Summy‐Long, J. Y. (1998) · Pharmacology · doi:10.1159/000028187 · Cited by 2
Effects of Intracerebroventricularly Administered Carbetocin on Social Behavior in Holstein Steers
Yayou, K., Ito, S., Kasuya, E., Sutoh, M., & Yamamoto, N. (2013) · Journal of Veterinary Medical Science · doi:10.1292/jvms.12-0560 · Cited by 2
Central modulation of affective touch, pain, and emotion in humans
Ellingsen, D. (2014) · Cited by 2
Ocytocine, douleur et émotions
Goyon, S., & Charlet, A. (2018) · Douleurs Évaluation - Diagnostic - Traitement · doi:10.1016/j.douler.2018.10.005 · Cited by 2
Measuring Affinity of Ligands to the Oxytocin Receptor Using Radioligand Binding
Werry, E. L., & Kassiou, M. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1759-5_14 · Cited by 2
Samson, W. K. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00307.2016 · Cited by 2
Oxytocin-Cholinergic Central Interaction: Implications for Non-Social Memory Formation
Medina, C., Krawczyk, M. C., Millan, J., Blake, M. G., & Boccia, M. M. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.028 · Cited by 2
Clinical Pharmacology of Motor Neurons
Guiloff, R. J. (1995) · Springer eBooks · doi:10.1007/978-1-4471-1871-8_15 · Cited by 2
Speisky, M. B., & Kalant, H. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90390-4 · Cited by 2
Arginine8-vasopressin potentiates the motor incoordinating effects of pentobarbital
Marchese, A., Mihic, S. J., Wu, P. H., & Kalant, H. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90276-v · Cited by 2
Neuropharmacokinetic Applications of in Vivo Monitoring Techniques
Hutson, P. H., Sarna, G. S., & Curzon, G. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb23657.x · Cited by 2
Evidence for intranasal oxytocin delivery to the brain: recent advances and future perspectivesPreprint
Quintana, D. S., Smerud, K. T., Andreassen, O. A., & Djupesland, P. G. (2018) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/fnhx5 · Cited by 3
Adams, J., Nishitani, S., Mun, J., Klinger, M., Landry, M. P., & Komatsu, N. (2025) · ACS in focus · doi:10.1021/acsinfocus.7e9007 · Cited by 1
Development and characterisation of novel oxytocin analogues for PET imaging
Pascali, G., Parmar, A., Zanoni, S., Arthur, A., Hering, A., Teakle, N., Markham, J. W., Zhang, B., Mackay, T., Klenner, M. A., et al. (2025) · Communications Chemistry · doi:10.1038/s42004-025-01649-1 · Cited by 1
Ahmad, N., Han, S., Utami, R. N., Baker, R. S., Helal, D. O., Li, Z., Tricklebank, M. D., Paloyelis, Y., Wang, J., Petrinovic, M. M., et al. (2025) · Small · doi:10.1002/smll.202511603 · Cited by 1
Merighi, A., Sbriz, M., & Lossi, L. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1839947 · Cited by 1
Oxytocin administration is a potential tool for behavioral management in felids
Burkhart, J. C., Heilbronner, S. R., & Packer, C. (2023) · Frontiers in Mammal Science · doi:10.3389/fmamm.2023.1148214 · Cited by 1
Oxytocin’s Effects in Cocaine and Other Psychostimulant Addictions
Lee, M. R., Rohn, M. C. H., Tanda, G., & Leggio, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803750-8.00023-3 · Cited by 1
Duodenal ulcer and its complications
Maksymchuk, D. (2021) · International Journal of Health Sciences · doi:10.53730/ijhs.v5n3.2014 · Cited by 1
Hoyda, T. D. (2010) · QSpace (Queen's University Library) · Cited by 1
Hypothalamic Neuropeptides and the Blood—Brain Barrier
Begley, D. J. (2006) · Elsevier eBooks · doi:10.1016/b978-012369442-3/50208-7 · Cited by 1
Actions of appetite regulating peptides on supraoptic nucleus (SON) oxytocin neurones
Velmurugan, S. (2009) · ERA · Cited by 1
Begley, D. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385095-9.00228-1
Subtype selective activation and molecular characterization of galanin receptors
Lundström, L. (2007) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Neurotransmitters in the central nervous system: Basic knowledge revisited
Lozić, M. (2015) · Medicinski podmladak · doi:10.5937/medpodm1502012l
Tracking effects of oxytocin crossing the blood brain barrier in vivo and in vitro
Chakraborty, T. (2024) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/6tnt-6n23
On oxytocin and social behavior
Hovey, D. (2018) · Gothenburg University Publications Electronic Archive (Gothenburg University)
CNIFERS: CELL-BASED BIOSENSORS WITH NANOMOLAR SENSITIVITY TO IN VIVO CHANGES IN NEUROMODULATION
Kircher, D. M., Lacin, M. E., Kleinfeld, D., & Slesinger, P. A. (2019) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789811206238_0002
Studies on the Optimization of Neuropeptides Detection in the Human Tear Film
Jabeen, A. (2020) · UWSpace (University of Waterloo)
Maternal overweight and obesity : impact on obstetric outcomes in adolescents and oxytocin in labor
Isgren, A. R. (2021) · Linköping University medical dissertations · doi:10.3384/diss.diva-173147
Comment, au fil du temps, l’ocytocine est devenue l’hormone de l’attachement
Freund‐Mercier, M. J. (2022) · Biologie Aujourd hui · doi:10.1051/jbio/2022014
Karthikeyan, M., Shrivastava, A., & Neff, A. (2023) · Seeds of Science · doi:10.53975/ykha-lrmn
Neuroendocrinology of Human Cooperation and Parental Care
Rilling, J. K. (2024) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-51112-7_3
Repetitive daily oxytocin treatment reduces weight gain but not acute neonatal procedural pain
Baudat, M., Joosten, E. A. J., & Simons, S. H. P. (2024) · Pediatric Research · doi:10.1038/s41390-024-03680-9
Monteros-Zúñiga, A. E. D. L., Almazán, J. L., Martı́nez-Lorenzana, G., Guillen-Paredes, M. C., Prieto, G. A., Condés‐Lara, M., & González‐Hernández, A. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110487
Iba, K., Masuda, Y., Kitano, R., Ohbayashi, K., Ago, Y., Nagai, H., Furuyashiki, T., Abe, C., & Iwasaki, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.16.694527
Sağlam, M. K., & Yanaşoğlu, E. (2026) · Sakarya Medical Journal · doi:10.31832/smj.1797857
The oxytocinergic descending control of pain and its modulation by neonatal maternal separation
Melchior, M. (2018) · theses.fr (ABES) · doi:10.70675/368c73c0ze731z4b57zb52cz8f31049fb33c
Circuits neuronaux sous-tendant la régulation émotionnelle par le système ocytocinergique
Goyon, S. (2018) · theses.fr (ABES) · doi:10.70675/c8c9bec0z7b79z4826z862az93b128e1ada6
Bertoni, A. (2019) · theses.fr (ABES) · doi:10.70675/d43fcf44zc66ez47a1zae43zd20439e2b233
Influence of the activities imposed by the human being on equine emotional responses
Mendonça, T. S. V. (2020) · theses.fr (ABES) · doi:10.70675/b12f870bz4cccz49dazaed0z2960f88d3776
L'astrocyte un nouvel acteur dans la modulation ocytocinergique : du réseau au comportement
Kerspern, D. (2020) · theses.fr (ABES) · doi:10.70675/386e1bfbz661dz4336zb1e0zb5dbce3b6f10
New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
Martucci, L. L. (2021) · theses.fr (ABES) · doi:10.70675/027d1ae2zd2ebz4677za019ze6ccd94cafe9
In vivo analysis of the antihyperalgesic activity of innovative compounds
Hilfiger, L. (2022) · theses.fr (ABES) · doi:10.70675/75d118c6zbe5ez4d20z9c25zd658f8cf399a
Manca, C., Paulus, J. P., Almeida, A. J. D., Caceres, A., Sosnowski, M. J., Hobson, B. A., Ferrer, E. E., Chaudhari, A. J., & Bales, K. L. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.06.028 · Cited by 1
Central administration of oxytocin increases social interaction and shoaling behaviour in guppies
Cabrera-Álvarez, M. J., Swaney, W. T., & Reader, S. M. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116363
Vasotocin influences mother–offspring associations in a facultatively family-living lizard
Lake, J., While, G. M., Ophir, A. G., Rubenstein, D. R., Witczak, L. R., & Whiting, M. J. (2026) · Behavioral Ecology · doi:10.1093/beheco/arag082
Metadata
- Authors
- Mens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B.
- Affiliations
- Utrecht University (NL)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1983-02
- Volume
- 262
- Issue
- 1
- Pages
- 143-149
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2062508009
- Cited by
- 360
- References
- 29
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 20 · 2021: 28 · 2020: 24 · 2019: 11 · 2018: 28 · 2017: 16 · 2016: 16 · 2015: 21 · 2014: 18 · 2013: 14 · 2012: 5
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- neurohypophyseal hormones, vasopressin, oxytocin, cerebrospinal fluid, blood-brain barrier penetration, peripheral administration, central nervous system action
- MeSH terms
- Animals, Arginine Vasopressin, Half-Life, Kinetics, Male, Oxytocin, Pituitary Hormones, Posterior, Rats, Inbred Strains, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
