Cited by 360Neuroendocrine regulation and behaviorCerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

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Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): Half-times of disappearance of these neuropeptides from CSF

Mens, Wim B.J., Witter, Albert, Van Wimersma Greidanus, Tjeerd B.·1983·Brain Research

DOI 10.1016/0006-8993(83)90478-x

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Abstract

The penetration of neurohypophyseal peptides after peripheral administration into the cerebrospinal fluid (CSF) was studied in freely moving rats. In addition, the clearance of these peptides from CSF was investigated. Increased concentrations of vasopressin (AVP) in CSF were detectable 2 min after s.c. injection of 5.0 micrograms of this peptide. Peak concentration was reached at 5 min after administration and this level declined slowly over the next hour. Administration of 5.0 micrograms oxytocin (OXT) s.c. or i.v. resulted in increased OXT levels in CSF within 10 min after application. After 60 min a significant elevation of OXT in CSF was no longer present. These data reveal that approximately 0.002% of the peripherally applied amount of AVP or OXT reached the central nervous system at 10 min after injection. AVP (2.5 ng) and OXT (5.0 ng) applied into one of the lateral brain ventricles reached the cisternal cavity within 2 min after administration. Both neuropeptides were cleared from the CSF with terminal half-times of 26 and 19 min for AVP and OXT, respectively. The present data demonstrate that neurohypophyseal hormones do cross the blood-brain barrier in amounts obviously sufficient to induce central actions.

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Authors: Mens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B.
Affiliations: Utrecht University (NL)
Venue: Brain Research
Publisher: Elsevier BV
Published: 1983-02
Volume: 262
Issue: 1
Pages: 143-149
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(83)90478-x
OpenAlex: W2062508009
Cited by: 360
References: 29
Citations by year: 2026: 6 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 20 · 2021: 28 · 2020: 24 · 2019: 11 · 2018: 28 · 2017: 16 · 2016: 16 · 2015: 21 · 2014: 18 · 2013: 14 · 2012: 5
FWCI: 12.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: neurohypophyseal hormones, vasopressin, oxytocin, cerebrospinal fluid, blood-brain barrier penetration, peripheral administration, central nervous system action
MeSH terms: Animals, Arginine Vasopressin, Half-Life, Kinetics, Male, Oxytocin, Pituitary Hormones, Posterior, Rats, Inbred Strains, Rats

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Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): Half-times of disappearance of these neuropeptides from CSF

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