Cited by 360Neuroendocrine regulation and behaviorCerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.

Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): Half-times of disappearance of these neuropeptides from CSF

Mens, Wim B.J., Witter, Albert, Van Wimersma Greidanus, Tjeerd B.·1983·Brain Research

Abstract

The penetration of neurohypophyseal peptides after peripheral administration into the cerebrospinal fluid (CSF) was studied in freely moving rats. In addition, the clearance of these peptides from CSF was investigated. Increased concentrations of vasopressin (AVP) in CSF were detectable 2 min after s.c. injection of 5.0 micrograms of this peptide. Peak concentration was reached at 5 min after administration and this level declined slowly over the next hour. Administration of 5.0 micrograms oxytocin (OXT) s.c. or i.v. resulted in increased OXT levels in CSF within 10 min after application. After 60 min a significant elevation of OXT in CSF was no longer present. These data reveal that approximately 0.002% of the peripherally applied amount of AVP or OXT reached the central nervous system at 10 min after injection. AVP (2.5 ng) and OXT (5.0 ng) applied into one of the lateral brain ventricles reached the cisternal cavity within 2 min after administration. Both neuropeptides were cleared from the CSF with terminal half-times of 26 and 19 min for AVP and OXT, respectively. The present data demonstrate that neurohypophyseal hormones do cross the blood-brain barrier in amounts obviously sufficient to induce central actions.

Overview

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Crossref · 10.1016/0006-8993(83)90478-x

Cites

28 of 28 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 29 references

Research works printed but not linked: 3

  1. Jones, P. M. and Robinson, I. C. A. F., Differential clearance of neurophysin and neurohypophyseal peptides from the cerebrospinal fluid in conscious guinea pigs,Neuroendocrinology, in press.
  2. Kozlowski, 1976, Neurosecretory pathways to the choroid plexus, IRC Med. Sci., 4, 299
  3. van Wimersma Greidanus, 1978, Behavioral changes of rats after neutralization of central available neuropeptides by administration of specific antisera, Vol. 88, 192

Cited by

Sorted by citations

Items 201–300 of 357

Metadata

Authors
Mens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B.
Affiliations
Utrecht University (NL)
Venue
Brain Research
Publisher
Elsevier BV
Published
1983-02
Volume
262
Issue
1
Pages
143-149
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2062508009
Cited by
360
References
29
Citations by year
2026: 6 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 20 · 2021: 28 · 2020: 24 · 2019: 11 · 2018: 28 · 2017: 16 · 2016: 16 · 2015: 21 · 2014: 18 · 2013: 14 · 2012: 5
FWCI
12.43
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
neurohypophyseal hormones, vasopressin, oxytocin, cerebrospinal fluid, blood-brain barrier penetration, peripheral administration, central nervous system action
MeSH terms
Animals, Arginine Vasopressin, Half-Life, Kinetics, Male, Oxytocin, Pituitary Hormones, Posterior, Rats, Inbred Strains, Rats

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