Cited by 360Neuroendocrine regulation and behaviorCerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.

Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): Half-times of disappearance of these neuropeptides from CSF

Mens, Wim B.J., Witter, Albert, Van Wimersma Greidanus, Tjeerd B.·1983·Brain Research

DOI 10.1016/0006-8993(83)90478-x

Open this paper in CoChat — free account

Abstract

The penetration of neurohypophyseal peptides after peripheral administration into the cerebrospinal fluid (CSF) was studied in freely moving rats. In addition, the clearance of these peptides from CSF was investigated. Increased concentrations of vasopressin (AVP) in CSF were detectable 2 min after s.c. injection of 5.0 micrograms of this peptide. Peak concentration was reached at 5 min after administration and this level declined slowly over the next hour. Administration of 5.0 micrograms oxytocin (OXT) s.c. or i.v. resulted in increased OXT levels in CSF within 10 min after application. After 60 min a significant elevation of OXT in CSF was no longer present. These data reveal that approximately 0.002% of the peripherally applied amount of AVP or OXT reached the central nervous system at 10 min after injection. AVP (2.5 ng) and OXT (5.0 ng) applied into one of the lateral brain ventricles reached the cisternal cavity within 2 min after administration. Both neuropeptides were cleared from the CSF with terminal half-times of 26 and 19 min for AVP and OXT, respectively. The present data demonstrate that neurohypophyseal hormones do cross the blood-brain barrier in amounts obviously sufficient to induce central actions.

Integrity signals

Registry

Crossref · 10.1016/0006-8993(83)90478-x

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Drugs and the Pharmaceutical Sciences
(2010) · Drugs and the pharmaceutical sciences · doi:10.1201/ihcdruphasci · Cited by 587
Behavioral effects of intraventricularly administered vasopressin and vasopressin fragments
de Wied, D. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90165-x · Cited by 359
Evidence for the Release of Vasopressin and Oxytocin into Cerebrospinal Fluid: Measurements in Plasma and CSF of Intact and Hypophysectomized Rats
Dogterom, J., Greidanus, T. B. V. W., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000122702 · Cited by 247
Entry of Opioid Peptides into the Central Nervous System
Рапопорт, С. И., Klee, W. A., Pettigrew, K. D., & Ohno, K. (1980) · Science · doi:10.1126/science.7350645 · Cited by 245
Opposite effects of oxytocin and vasopressin on avoidance behaviour and hippocampal theta rhythm in the rat
BOHUS, B., URBAN, I., VANWIMERSMAGREIDANUS, T., & DEWIED, D. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90107-7 · Cited by 231
Self-citation
The effects of ACTH- and vasopressin-analogues on CO2-induced retrograde amnesia in rats
Rigter, H., van Riezen, H., & de Wied, D. (1974) · Physiology & Behavior · doi:10.1016/0031-9384(74)90092-4 · Cited by 213
Intraventricular administration of anti-vasopressin serum inhibits memory consolidation in rats
Greidanus, T. B. V. W., Dogterom, J., & Wied, D. D. (1975) · Life Sciences · doi:10.1016/s0024-3205(75)80015-4 · Cited by 204
THE CEREBROSPINAL FLUID AS A PATHWAY IN NEUROENDOCRINE INTEGRATION
Rodríguez, E. M. (1976) · Journal of Endocrinology · doi:10.1677/joe.0.0710407 · Cited by 197
Vasopressin in cerebrospinal fluid and plasma of man, dog, and rat.
Dogterom, J., Greidanus, T. B. V. W., & de Wied, D. (1978) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1978.234.5.e463 · Cited by 157
Postnatal development of bulk flow in the cerebrospinal fluid system of the albino rat: Clearance of carboxyl-[14C]inulin after intrathecal infusion
Bass, N. H., & Lundborg, P. G. (1973) · Brain Research · doi:10.1016/0006-8993(73)90668-9 · Cited by 153

Show all 29 references

Research works printed but not linked: 3

Jones, P. M. and Robinson, I. C. A. F., Differential clearance of neurophysin and neurohypophyseal peptides from the cerebrospinal fluid in conscious guinea pigs,Neuroendocrinology, in press.
Kozlowski, 1976, Neurosecretory pathways to the choroid plexus, IRC Med. Sci., 4, 299
van Wimersma Greidanus, 1978, Behavioral changes of rats after neutralization of central available neuropeptides by administration of specific antisera, Vol. 88, 192

Sorted by citations

Items 101–200 of 357

The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders
Abramova, O. V., Zorkina, Y., Ushakova, V. M., Zubkov, E. A., Morozova, A. Y., & Chekhonin, V. P. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102079 · Cited by 75
Involvement of the oxytocin system in the bed nucleus of the stria terminalis in the sex-specific regulation of social recognition
Dumais, K. M., Alonso, A. G., Immormino, M. A., Bredewold, R., & Veenema, A. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.007 · Cited by 79
Effects of enhanced cerebrospinal fluid levels of vasopressin, vasopressin antagonist or vasoactive intestinal polypeptide on circadian sleep-wake rhythm in the rat
Kruisbrink, J., Mirmiran, M., van der Woude, T. P., & Boer, G. J. (1987) · Brain Research · doi:10.1016/0006-8993(87)90570-1 · Cited by 69
Coming Full Circle: Contributions of Central and Peripheral Oxytocin Actions to Energy Balance
Ho, J. M., & Blevins, J. E. (2012) · Endocrinology · doi:10.1210/en.2012-1751 · Cited by 67
Somato‐dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation
Brown, C. H., Ludwig, M., Tasker, J. G., & Stern, J. E. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12856 · Cited by 72
Oxytocin: Parallel Processing in the Social Brain?
Dölen, G. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12284 · Cited by 65
Multiple signalling modalities mediated by dendritic exocytosis of oxytocin and vasopressin
Ludwig, M., & Stern, J. E. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0182 · Cited by 69
No. 355-Physiologic Basis of Pain in Labour and Delivery: An Evidence-Based Approach to its Management
Bonapace, J., Gagné, G., Chaillet, N., Gagnon, R. F., Hébert, E., & Buckley, S. J. (2018) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2017.08.003 · Cited by 66
Maternal Behavior
Numan, M. J., FLEMING, A., & Lévy, F. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50040-3 · Cited by 63
Social preference and maternal defeat-induced social avoidance in virgin female rats: Sex differences in involvement of brain oxytocin and vasopressin
Lukas, M., & Neumann, I. D. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.013 · Cited by 65
Neuromodulatory function of neuropeptides in the normal CNS
Merighi, A., Salio, C., Ferrini, F., & Lossi, L. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.02.001 · Cited by 69
The Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication
Maejima, Y., Yokota, S., Nishimori, K., & Shimomura, K. (2018) · Neuroendocrinology · doi:10.1159/000489263 · Cited by 68
Targeting the Oxytocin System: New Pharmacotherapeutic Approaches
Gulliver, D. W., Werry, E. L., Reekie, T. A., Katte, T. A., Jorgensen, W. T., & Kassiou, M. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.11.001 · Cited by 67
Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 63
Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord
Oti, T., Satoh, K., Uta, D., Nagafuchi, J., Tateishi, S., Ueda, R., Takanami, K., Young, L. J., Galione, A., Morris, J. F., et al. (2021) · Current Biology · doi:10.1016/j.cub.2020.09.089 · Cited by 63
Effects of positive and negative human contacts and intranasal oxytocin on cerebrospinal fluid oxytocin
Rault, J. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.03.015 · Cited by 64
Dendritic Release of Neurotransmitters
Ludwig, M., Apps, D. K., Menzies, J. R. W., Patel, J. C., & Rice, M. E. (2016) · Comprehensive physiology · doi:10.1002/cphy.c160007 · Cited by 75
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience
Sharma, S. R., Gonda, X., Dome, P., & Tarazi, F. I. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107602 · Cited by 61
The Role of Hypothalamic Neuropeptides in Neurogenesis and Neuritogenesis
Bakoš, J., Zatkova, M., Bačová, Z., & Ostatníková, D. (2016) · Neural Plasticity · doi:10.1155/2016/3276383 · Cited by 63
Effect of varying the duration of pre-test cage habituation on oxytocin induction of short-latency maternal behavior
Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90396-3 · Cited by 60
Distinct BOLD Activation Profiles Following Central and Peripheral Oxytocin Administration in Awake Rats
Ferris, C. F., Yee, J. R., Kenkel, W. M., Dumais, K. M., Moore, K., Veenema, A. H., Kulkarni, P. P., Perkybile, A. M., & Carter, C. S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00245 · Cited by 60
A systematic review and quantitative meta‐analysis of the effects of oxytocin on feeding
Leslie, M. R., Silva, P., Paloyelis, Y., Blevins, J. E., & Treasure, J. L. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12584 · Cited by 60
Infanticide and parental behavior in wild female house mice: Effects of ovariectomy, adrenalectomy and administration of oxytocin and prostaglandin F2α
McCarthy, M. M., Bare, J. E., & Saal, F. S. V. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90066-1 · Cited by 58
Evidence that [125I]N-Tyr-delta sleep-inducing peptide crosses the blood-brain barrier by a non-competitive mechanism
Banks, W. A., Kastin, A. J., & Coy, D. H. (1984) · Brain Research · doi:10.1016/0006-8993(84)91088-6 · Cited by 60
Non-invasive measurement of small peptides in the common marmoset (Callithrix jacchus): A radiolabeled clearance study and endogenous excretion under varying social conditions
Seltzer, L. J., & Ziegler, T. E. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.12.012 · Cited by 58
Diversity of Axonal and Dendritic Contributions to Neuronal Output
Goaillard, J., Moubarak, E. M., Tapia, M., & Tell, F. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00570 · Cited by 61
Current findings on the role of oxytocin in the regulation of food intake
Spetter, M. S., & Hallschmid, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.007 · Cited by 61
Putative roles of neuropeptides in vagal afferent signaling
de Lartigue, G. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.011 · Cited by 56
Anti-depression effects of Danggui-Shaoyao-San, a fixed combination of Traditional Chinese Medicine, on depression model in mice and rats
Xu, F., Peng, D., Tao, C., Yin, D., Kou, J., Zhu, D., & Yu, B. (2011) · Phytomedicine · doi:10.1016/j.phymed.2011.05.002 · Cited by 56
Effects of α‐Melanocyte‐Stimulating Hormone on Magnocellular Oxytocin Neurones and their Activation at Intromission in Male Rats
Caquineau, C., Leng, G., Guan, X.-M., Jiang, M., der Ploeg, L. H. T. V., & Douglas, A. J. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01465.x · Cited by 58
Delivering Peptides to the Central Nervous System: Dilemmas and Strategies
Banks, W. A., Kastin, A. J., & Barrera, C. M. (1991) · Pharmaceutical Research · doi:10.1023/a:1015884603456 · Cited by 54
Oxytocin and Eating Disorders: A Narrative Review on Emerging Findings and Perspectives
Giel, K. E., Zipfel, S., & Hallschmid, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666171128143158 · Cited by 58
Effects of Intranasal Administration of Oxytocin and Vasopressin on Social Cognition and Potential Routes and Mechanisms of Action
Yao, S., & Kendrick, K. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020323 · Cited by 55
Maternal and newborn plasma oxytocin levels in response to maternal synthetic oxytocin administration during labour, birth and postpartum – a systematic review with implications for the function of the oxytocinergic system
Buckley, S. J., Uvnäs‐Moberg, K., Pajalić, Z., Luegmair, K., Ekström, A., Dencker, A., Massarotti, C., Kotłowska, A., Callaway, L. K., Morano, S., et al. (2023) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-022-05221-w · Cited by 58
Intranasal oxytocin administration promotes emotional contagion and reduces aggression in a mouse model of callousness
Zoratto, F., Sbriccoli, M., Martinelli, A., Glennon, J. C., Macrı̀, S., & Laviola, G. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.010 · Cited by 53
The vagus nerve mediates the suppressing effects of peripherally administered oxytocin on methamphetamine self-administration and seeking in rats
Everett, N. A., Turner, A. J., Costa, P. A., Baracz, S. J., & Cornish, J. L. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0719-7 · Cited by 52
Presynaptic actions of endocannabinoids mediate α-MSH-induced inhibition of oxytocin cells
Sabatier, N., & Leng, G. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00667.2005 · Cited by 52
The Regulation of Oxytocin Receptor Gene Expression during Adipogenesis
Yi, K., So, K., Hata, Y., Suzuki, Y., Kato, D., Watanabe, K., Aso, H., Kasahara, Y., Nishimori, K., Chen, C., et al. (2015) · Journal of neuroendocrinology · doi:10.1111/jne.12268 · Cited by 51
Speculations Concerning the Physiological Significance of Central Oxytocin in Maternal Behavior
McCarthy, M. M., Kow, L., & Pfaff, D. W. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34347.x · Cited by 50
Prior Exposure To Oxytocin Mimics the Effects Of Social Contact and Facilitates Sexual Behaviour In Females
Cushing, & Carter (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00382.x · Cited by 50
Salusin-β in paraventricular nucleus increases blood pressure and sympathetic outflow via vasopressin in hypertensive rats
Chen, W., Sun, H., Zhang, F., Zhou, Y., Xiong, X., Wang, J., & Zhu, G. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt031 · Cited by 49
A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain
Hilfiger, L., Zhao, Q., Kerspern, D., Inquimbert, P., Andry, V., Goumon, Y., Darbon, P., Hibert, M., & Charlet, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-59929-w · Cited by 47
Penetration of DGAVP (Org 5667) across the blood-brain barrier in human subjects
Riekkinen, P. J., Legros, J., Sennef, C., Jolkkonen, J., Smitz, S., & Soininen, H. S. (1987) · Peptides · doi:10.1016/0196-9781(87)90101-x · Cited by 49
Oxytocin—a social peptide? Deconstructing the evidence
Leng, G., Leng, R., & Ludwig, M. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0055 · Cited by 51
Prolactin and oxytocin: potential targets for migraine treatment
Szewczyk, A. K., Ulutas, S., Aktürk, T., Al‐Hassany, L., Börner, C., Cernigliaro, F., Kodounis, M., Cascio, S. L., Mikolajek, D., Onan, D., et al. (2023) · The Journal of Headache and Pain · doi:10.1186/s10194-023-01557-6 · Cited by 51
How does oxytocin modulate human behavior?
Yao, S., & Kendrick, K. M. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02898-1 · Cited by 61
Neuroendocrine‐Autonomic Integration in the Paraventricular Nucleus : Novel Roles for Dendritically Released Neuropeptides
Stern, J. E. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12252 · Cited by 48
Oxytocin Induces a Conditioned Social Preference in Female Mice
Kent, K., Arientyl, V., Khachatryan, M. M., & Wood, R. I. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12075 · Cited by 48
Antagonism of mGlu2/3 receptors in the nucleus accumbens prevents oxytocin from reducing cued methamphetamine seeking in male and female rats
Bernheim, A. P., Leong, K.-C., Berini, C., & Reichel, C. M. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.08.012 · Cited by 47
The role of the vasopressin V1A receptor in oxytocin modulation of methamphetamine primed reinstatement
Everett, N. A., McGregor, I. S., Baracz, S. J., & Cornish, J. L. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.036 · Cited by 44
WITHDRAWN: How to Increase and Decrease the Strength of Memory Traces: The Effects of Drugs and Hormones
Martinez, J. L., Schulteis, G., & Weinberger, S. B. (1991) · Elsevier eBooks · doi:10.1016/b978-0-12-474993-1.50009-2 · Cited by 43
Neuropsychological effects of vasopressin in healthy humans
Born, J., Pietrowsky, R., & L. Fehm, H. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61595-2 · Cited by 42
Relay of peripheral oxytocin to central oxytocin neurons via vagal afferents for regulating feeding
Iwasaki, Y., Parmila, K., Wang, L. A., Hidema, S., Nishimori, K., & Yada, T. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.09.039 · Cited by 41
Oxytocin and Behavior
Kovács, G. L. (1986) · Current topics in neuroendocrinology · doi:10.1007/978-3-642-70414-7_4 · Cited by 43
Somatodendritic dynorphin release: orchestrating activity patterns of vasopressin neurons
Brown, C. H., Scott, V. M., Ludwig, M., Leng, G., & Bourque, C. W. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351236 · Cited by 41
Oxytocin Receptor Signaling in Vascular Function and Stroke
McKay, E. C., & Counts, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.574499 · Cited by 45
Studies of vasopressin in the human cerebrospinal fluid
Sørensen, P. S. (1986) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1986.tb04633.x · Cited by 41
Salt-induced sympathoexcitation involves vasopressin V1a receptor activation in the paraventricular nucleus of the hypothalamus
Ribeiro, N., Panizza, H. N., dos Santos, K. M., Ferreira‐Neto, H. C., & Antunes, V. R. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00312.2015 · Cited by 40
Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates
Galbusera, A., Felice, A. D., Girardi, S., Bassetto, G., Maschietto, M., Nishimori, K., Chini, B., Papaleo, F., Vassanelli, S., & Gozzi, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.283 · Cited by 38
Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations
Yeomans, D. C., Hanson, L. R., Carson, D. S., Tunstall, B. J., Lee, M. R., Tzabazis, A., Jacobs, D. L., & Frey, W. H. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01511-7 · Cited by 42
Intranasal Administration for Pain: Oxytocin and Other Polypeptides
Bharadwaj, V. N., Tzabazis, A., Klukinov, M., Manering, N. A., & Yeomans, D. C. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13071088 · Cited by 43
Measurement of Efflux Rates from Brain to Blood
Banks, W. A., Fasold, M. B., & Kastin, A. J. (2003) · Humana Press eBooks · doi:10.1385/0-89603-399-6:353 · Cited by 40
Neuropeptides and Memory
Koob, G. F. (1987) · Springer eBooks · doi:10.1007/978-1-4613-1819-4_9 · Cited by 40
Endocrine‐Autonomic Linkages
Sladek, C. D., Michelini, L. C., Stachenfeld, N. S., Stern, J. E., & Urban, J. H. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140028 · Cited by 51
Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders
Quintana, D. S., Dieset, I., Elvsåshagen, T., Westlye, L. T., & Andreassen, O. A. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.004 · Cited by 39
Pituitary crosstalk with bone, adipose tissue and brain
Zaidi, M., Yuen, T., & Kim, S. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00894-5 · Cited by 44
Involvement of Central Cholinergic Mechanisms in the Effects of Oxytocin and an Oxytocin Receptor Antagonist on Retention Performance in Mice
Boccia, M. M., & Baratti, C. M. (2000) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1999.3954 · Cited by 39
Penetration of the blood-brain barrier by peripheral neuropeptides: new approaches to enhancing transport and endogenous expression
Lee, M. R., & Jayant, R. D. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2959-y · Cited by 39
Sniffing oxytocin: Nose to brain or nose to blood?
Yao, S., Chen, Y., Zhuang, Q., Zhang, Y., Lan, C., Zhu, S., Becker, B., & Kendrick, K. M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02075-2 · Cited by 41
Intranasal application of vasopressin fails to elicit changes in brain immediate early gene expression, neural activity and behavioural performance of rats
Ludwig, M., Tobin, V. A., Callahan, M. F., Papadaki, E., Becker, A., Engelmann, M., & Leng, G. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12046 · Cited by 37
In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing
Kou, J., Lan, C., Zhang, Y., Wang, Q., Zhou, F., Zhao, Z., Montag, C., Yao, S., Becker, B., & Kendrick, K. M. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01241-w · Cited by 39
Information Processing in the Hypothalamus: Peptides and Analogue Computation
Leng, G., & Ludwig, M. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01428.x · Cited by 36
Oxytocin alters cell fate selection of rat neural progenitor cells in vitro
Palanisamy, A., Kannappan, R., Xu, Z., Martino, A., Friese, M. B., Boyd, J. D., Crosby, G. J., & Culley, D. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191160 · Cited by 36
An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow
Fukushima, A., Kataoka, N., & Nakamura, K. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111380 · Cited by 41
Release of Oxytocin into Blood and into Cerebrospinal Fluid Induced by Naloxone in Anaesthetized Morphine‐Dependent Rats: The Role of the Paraventricular Nucleus
Coombes, J. E., Robinson, I. C. A. F., Antoni, F. A., & Russell, J. A. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00316.x · Cited by 36
Vasopressin reduces release from vasopressin-neurons and oxytocin-neurons by acting on V2-like receptors
Cheng, S. W. T., & North, W. G. (1989) · Brain Research · doi:10.1016/0006-8993(89)91332-2 · Cited by 36
The role of vasopressin in olfactory and visual processing
Wacker, D. W., & Ludwig, M. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2867-1 · Cited by 37
Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system
Sasaki, K., Ferdousi, F., Fukumitsu, S., Kuwata, H., & Isoda, H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112291 · Cited by 37
Oxytocinase in the Female Rat Hypothalamus: A Novel Mechanism Controlling Oxytocin Neurones During Lactation
Tobin, V. A., Arechaga, G., Brunton, P. J., Russell, J. A., Leng, G., Ludwig, M., & Douglas, A. J. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12141 · Cited by 34
Sex differences in neural activation following different routes of oxytocin administration in awake adult rats
Dumais, K. M., Kulkarni, P. P., Ferris, C. F., & Veenema, A. H. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.04.003 · Cited by 34
Functional role of intrahypothalamic release of oxytocin and vasopressin: consequences and controversies
Ludwig, M. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.4.e537 · Cited by 34
Saturable efflux of the peptides RC-160 and Tyr-MIF-1 by different parts of the blood-brain barrier
Banks, W. A., Kastin, A. J., Sam, H., Cao, V. T., King, B. M., Maness, L. M., & Schally, A. V. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90100-7 · Cited by 34
New directions in the treatment of autism spectrum disorders from animal model research
Chadman, K. K., Guariglia, S. R., & Yoo, J. H. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.678828 · Cited by 33
A meta-analysis of hormone administration effects on cooperative behaviours: oxytocin, vasopressin, and testosterone
Yang, X., Wang, W., Wang, X. T., & Wang, Y. W. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.033 · Cited by 31
Probing Neuropeptide Volume Transmission In Vivo by Simultaneous Near‐Infrared Light‐Triggered Release and Optical Sensing**
Xiong, H., Lacin, E., Ouyang, H. X., Naik, A. A., Xu, X., Xie, C., Youn, J., Wilson, B. A., Kumar, K., Kern, T., et al. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202206122 · Cited by 33
Social Cognition
Patin, A., & Hurlemann, R. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-16522-6_10 · Cited by 37
A functional MRI study on how oxytocin affects decision making in social dilemmas: Cooperate as long as it pays off, aggress only when you think you can win
Lambert, B., Declerck, C. H., Boone, C., & Parizel, P. M. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.06.011 · Cited by 30
Vascular responses to vasopressin are tone-dependent in the cerebral circulation of the newborn pig.
Armstead, W. M., Mirro, R., Busija, D. W., & Leffler, C. W. (1989) · Circulation Research · doi:10.1161/01.res.64.1.136 · Cited by 30
Oxytocin as an Anti-obesity Treatment
Niu, J., Tong, J., & Blevins, J. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.743546 · Cited by 30
The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease
Aulinas, A., & Lawson, E. A. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf008 · Cited by 31
Design of Oxytocin Analogs
Wiśniewski, K. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9504-2_11 · Cited by 30
Central oxytocin signaling inhibits food reward-motivated behaviors and VTA dopamine responses to food-predictive cues in male rats
Liu, C. M., Hsu, T. M., Suarez, A. N., Subramanian, K. S., Fatemi, R. A., Cortella, A. M., Noble, E. E., Roitman, M. F., & Kanoski, S. E. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104855 · Cited by 29
Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges
Che, X., Cai, J., Liu, Y., Xu, T., Yang, J., & Wu, C. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107820 · Cited by 28
Role of Oxytocin in Different Neuropsychiatric, Neurodegenerative, and Neurodevelopmental Disorders
Ghazy, A. A., Soliman, O., Elbahnasi, A. I., Alawy, A. Y., Mansour, A. M., & Gowayed, M. A. (2022) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2022_72 · Cited by 27
Intranasal oxytocin administration facilitates the induction of long-term potentiation and promotes cognitive performance of maternally separated rats
Joushi, S., Esmaeilpour, K., Masoumi‐Ardakani, Y., Esmaeili‐Mahani, S., & Sheibani, V. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105044 · Cited by 28
Effects of Oxytocin Administration on the Response of Piglets to Weaning
Rault, J., Dunshea, F. R., & Pluske, J. R. (2015) · Animals · doi:10.3390/ani5030371 · Cited by 27
Current and Emerging Treatments for Premature Ejaculation
McMahon, C. G. (2015) · Sexual Medicine Reviews · doi:10.1002/smrj.49 · Cited by 27
Vasopressin and Animal Behavior
Gash, D. M., Herman, J. P., & Thomas, G. J. (1987) · Springer eBooks · doi:10.1007/978-1-4615-8129-1_14 · Cited by 27
Stress-induced oxytocin release and oxytocin cell number and size in prepubertal and adult male and female rats
Minhas, S., Liu, C. M., Galdamez, J., So, V. M., & Romeo, R. D. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.03.014 · Cited by 26
Emerging and investigational drugs for premature ejaculation
McMahon, C. G. (2016) · Translational Andrology and Urology · doi:10.21037/tau.2016.04.02 · Cited by 26

Authors: Mens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B.
Affiliations: Utrecht University (NL)
Venue: Brain Research
Publisher: Elsevier BV
Published: 1983-02
Volume: 262
Issue: 1
Pages: 143-149
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(83)90478-x
OpenAlex: W2062508009
Cited by: 360
References: 29
Citations by year: 2026: 6 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 20 · 2021: 28 · 2020: 24 · 2019: 11 · 2018: 28 · 2017: 16 · 2016: 16 · 2015: 21 · 2014: 18 · 2013: 14 · 2012: 5
FWCI: 12.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: neurohypophyseal hormones, vasopressin, oxytocin, cerebrospinal fluid, blood-brain barrier penetration, peripheral administration, central nervous system action
MeSH terms: Animals, Arginine Vasopressin, Half-Life, Kinetics, Male, Oxytocin, Pituitary Hormones, Posterior, Rats, Inbred Strains, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): Half-times of disappearance of these neuropeptides from CSF

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks