Analgesia elicited by prefrontal stimulation

Patrick Hardy, S.G.

doi:10.1016/0006-8993(85)90093-9

Cited by 133Pain Mechanisms and TreatmentsPain Management and TreatmentPain Management and Placebo Effect

Analgesia elicited by prefrontal stimulation

Patrick Hardy, S.G.·1985·Brain Research

DOI 10.1016/0006-8993(85)90093-9

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Abstract

Bipolar stimulating electrodes were placed into the medial prefrontal cortex (PFC) or control sites (occipital or cerebellar cortices) in adult male rats. Subsequently, it was determined that PFC stimulation resulted in a significant elevation of nociceptive response latencies, as tested using hot plate and tail flick techniques. Stimulation in control sites did not produce an increase in these response latencies. Rats receiving PFC stimulation were able to respond normally to various innocuous stimuli. Furthermore, seizures were not observed in these rats. These facts indicated that PFC stimulation did not disorient the animals nor inhibit their voluntary motor activity. The results of this study seem to indicate that the PFC is a site from which stimulus-produced analgesia may be elicited.

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The insula is involved in critical aspects underlying SUDs, such as interoception, decision making, anxiety, pain perception, cognition, mood, threat recognition, and conscious urges.
“The insula, a region of the cerebral cortex, is known to be involved in critical aspects underlying SUDs, such as interoception, decision making, anxiety, pain perception, cognition, mood, threat recognition, and conscious urges.”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Hardy, 1985

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Authors: Patrick Hardy, S. G.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1985-07
Volume: 339
Issue: 2
Pages: 281-284
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(85)90093-9
OpenAlex: W1978774896
Cited by: 133
References: 16
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 10 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 2
FWCI: 3.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2s07rr005386-30)
National Center for Research Resources (5 S07 RR05386)
Topics: Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: medial prefrontal cortex, electrical stimulation, nociception, hot plate test, tail flick, bipolar electrodes, seizures, rats
MeSH terms: Analgesia, Animals, Brain Mapping, Electric Stimulation, Frontal Lobe, Male, Neural Pathways, Pain, Periaqueductal Gray, Rats, Inbred Strains, Reaction Time, Superior Colliculi, Rats

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