Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction
Open accessAbstract
Background Nicotine is the principal component of tobacco smoke, resulting in addiction, and recent evidence suggests that damage to the insular cortex (insula) disrupts tobacco addiction in human smokers. However, the effect of an inactivation of this structure in an animal model of nicotine addiction has yet to be evaluated. Methods To study this question, we investigated the effects of reversible inactivation of the granular insula by local injection of a gamma-aminobutyric acid agonists mixture (baclofen/muscimol) on nicotine self-administration (SA) under fixed and progressive ratio and on reinstatement of nicotine seeking induced by nicotine priming or nicotine-associated cues in rats. We also evaluated the effects of granular insula inactivation on food SA and relapse as a control. Results The inactivation of the granular insula decreased nicotine SA under both fixed and progressive ratios without affecting the SA of food under the same schedules of reinforcement. This inactivation also prevented the reinstatement, after extinction, of nicotine seeking induced by nicotine-associated cues or nicotine priming without modifying the reinstatement of food seeking. Conclusions Our study indicates that the integrity of the granular insula is necessary for exhibiting motivation to take nicotine and to relapse to nicotine seeking but not for consuming food pellets or to relapse for food seeking. Indeed, it might be interesting to study the effect of methods that are able to modulate the activity of the insula--such as repetitive transcranial magnetic stimulation or deep brain stimulation--on tobacco addiction and relapse in humans.
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aAgIC or pGIC chemical inactivation attenuates nicotine taking under various ratio schedules of reinforcement.
“Our own laboratory demonstrated that aAgIC or pGIC chemical inactivation attenuates nicotine taking, under various ratio schedules of reinforcement”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Forget et al., 2010
aAgIC or pGIC inactivation demonstrated no effect on food taking in rats under a moderately restricted diet.
“These methods of inactivation demonstrated no effect on food taking in rats under a moderately restricted diet.”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Forget et al., 2010
aAgIC or pGIC inactivation attenuates nicotine seeking.
“Our own laboratory demonstrated that aAgIC or pGIC inactivation attenuates nicotine seeking”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Forget et al., 2010
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- Authors
- Forget, B., Pushparaj, A., & Le Foll, B.
- Affiliations
- University of Toronto (CA)
- ORCID
- Pushparaj, Abhiram
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 68
- Issue
- 3
- Pages
- 265-271
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2035027501
- Cited by
- 153
- References
- 58
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 13 · 2015: 17 · 2014: 7 · 2013: 14 · 2012: 13
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ontario Ministry of Research, Innovation and Science
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine dependence, insula, neural inactivation, nicotine self-administration, relapse, food self-administration, motivation
- MeSH terms
- Analysis of Variance, Animals, Association Learning, Baclofen, Behavior, Animal, Cerebral Cortex, Conditioning, Classical, Disease Models, Animal, Drug Combinations, Extinction, Psychological, Male, Microinjections, Motivation, Muscimol, Nicotine, Reinforcement Schedule, Self Administration, Tobacco Use Disorder, Behavior, Addictive, Nicotinic Agonists, GABA Agonists, Rats
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