Circadian rhythm in the light response of rat retinal disk-shedding and autophagy
Abstract
Under a light-dark cycle, disk-shedding and autophagy in the rat retina peak in the early and mid light phase, respectively. Under constant conditions, disk-shedding and autophagy responses after light stimulation were elicited at different time points of a 24-h cycle. The greatest magnitude of response occurred in the late dark and early light phase. Thus there is a circadian variation of the light response of important metabolic parameters in the mammalian retina. Inhibition of dopamine synthesis during the early light phase caused a significant dampening of the light responses of both disk-shedding and autophagy.
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Photoreceptor tip shedding is maximal in the morning just after onset of the light cycle, linking the process to circadian rhythms.
“Photoreceptor tip shedding occurs throughout the day, but it is maximal in the morning just after the onset of the light cycle, [8][9][10] linking the process to circadian rhythms.41,51”
From RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye (2017) · cites this paper as [51]
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The Retinal Pigment Epithelium in Visual Function
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- Authors
- Reme´, C., Wirz-Justice, A., Rhyner, A., & Hofmann, S.
- Affiliations
- University of Zurich (CH)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1986-03
- Volume
- 369
- Issue
- 1-2
- Pages
- 356-360
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2092763268
- Cited by
- 84
- References
- 16
- Citations by year
- 2025: 5 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 3 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- circadian rhythm, autophagy, light response, retina, light-dark cycle, dopamine synthesis inhibition, photoreceptor metabolism
- MeSH terms
- Animals, Autophagy, Circadian Rhythm, Dopamine, Light, Male, Methyltyrosines, Photoreceptor Cells, Rats, Inbred F344, alpha-Methyltyrosine, Rats
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