Rod outer segment disk shedding in rat retina: relationship to cyclic lighting

LaVail, Matthew M.

doi:10.1126/science.982063

Cited by 689Retinal Development and DisordersCircadian rhythm and melatoninCellular transport and secretion

Rod outer segment disk shedding in rat retina: relationship to cyclic lighting

LaVail, Matthew M.·1976·Science

DOI 10.1126/science.982063

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Abstract

When albino rats are reared in cyclic light, a burst of rod outer segment disk shedding occurs in the retina soon after the onset of light. The number of large packets of outer segment disks (phagosomes) in the pigment epithelium at this time is 2.5 to 5 times greater than at any other time of day or night. The subsequent degradation of large phagosomes to smaller structures within pigment epithelial cells proceeds rapidly. The burst of disk shedding follows a circadian rhythm for at least 3 days, since it occurs in continuous darkness at the same time without the onset of light.

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LaVail (1976) first reported a greater number of phagosomes in the rat RPE after light onset.
“LaVail (1976) first reported a greater number of phagosomes in the rat RPE after light onset.”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
Blockage of the rat pineal gland with reserpine prevented the sudden increase in phagosome number that occurs after light onset, suggesting some extraocular influence on circadian OS phagocytosis.
“However, in his original paper, LaVail showed that blockage of the rat pineal gland with reserpine prevented the sudden increase in phagosome number that occurs after light onset (LaVail, 1976), suggesting some extraocular influence on circadian OS phagocytosis.”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
Most animals (including mouse, rat, cat, hamster, Xenopus laevis, goldfish, rabbit, and chick) appear to be entrained to a circadian rhythm, which is cued by the light/dark cycle and persists even when the animal is maintained in absolute darkness, but not in absolute light.
“Most animals (including mouse, rat, cat, hamster, Xenopus laevis, goldfish, rabbit, and chick) appear to be entrained to a circadian rhythm, which is cued by the light/dark cycle and persists even when the animal is maintained in absolute darkness (LaVail, 1976; Besharse et al., 1977; Grace et al., 1996), but not in absolute light (Teirstein et al., 1980).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
Flatmounts of the RPE reflect the in vivo circadian rhythm of OS phagocytosis due to their fresh dissection.
“due to their fresh dissection, reflect the in vivo circadian rhythm of OS phagocytosis (LaVail, 1976)”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
POS disk phagocytosis is triggered according to a daily cycle at the beginning of the light phase.
“POS disk phagocytosis is triggered according to a daily cycle at the beginning of the light phase (LaVail, 1976)”
From Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis (2015) · cites this paper as LaVail, 1976

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Authors: LaVail, M. M.
Affiliations: Boston Children's Hospital (US)
Corresponding author: LaVail, Matthew M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1976-12-03
Volume: 194
Issue: 4269
Pages: 1071-1074
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.982063
OpenAlex: W2051747007
Cited by: 689
References: 20
Citations by year: 2026: 13 · 2025: 19 · 2024: 16 · 2023: 17 · 2022: 23 · 2021: 14 · 2020: 24 · 2019: 18 · 2018: 24 · 2017: 16 · 2016: 9 · 2015: 25 · 2014: 21 · 2013: 11 · 2012: 15
FWCI: 10.66
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: phagosome, retinal pigment epithelium, circadian rhythm, albino rats, photoreceptors
MeSH terms: Animals, Circadian Rhythm, Light, Organoids, Phagocytosis, Photoreceptor Cells, Pigment Epithelium of Eye, Reserpine, Rats

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Rod outer segment disk shedding in rat retina: relationship to cyclic lighting

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