The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Oxytocin potently enhances novelty-induced grooming behavior in the rat
Abstract
Intracerebroventricular (i.c.v.) injection of oxytocin was followed by an enhancement of novelty-induced grooming in male and female rats. This effect was dose-dependent, in a dose range of 0.1-10 micrograms. Grooming activity of rats injected i.c.v. with 10 micrograms of oxytocin was 9-fold higher than that of saline-injected controls. The analysis of behavioral element composition revealed an increased occurrence of genital grooming in oxytocin-injected rats. A time-course study revealed a sustained increase in grooming activity of oxytocin-treated rats during 45 min of behavioral testing. Intraperitoneal (i.p.) injection of the dopamine antagonist, haloperidol, totally suppressed oxytocin-enhanced grooming. Furthermore, i.p. injection of the opiate receptor antagonist, naloxone, was followed by an attenuation but not a suppression of grooming enhanced by i.c.v. administration of oxytocin. In addition, a small but significant increase in grooming activity was observed after subcutaneous injection of oxytocin. These results suggest that oxytocin-enhanced grooming behavior involves central mechanisms, e.g. dopamine and opioid transmission in the brain.
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In the citing paper
“in rats OXT-enhanced grooming is attenuated by the opiate antagonist naloxone”
From An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits (2014) · cites this paper as Drago et al, 1986
In the citing paper
“suggesting that an interplay between OXT and endorphins may have contributed to the observed pattern of effects.”
From An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits (2014) · cites this paper as Drago et al, 1986
Citations
Cites
Oxytocin induces maternal behavior in virgin female rats
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ACTH-induced excessive grooming in the rat
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Cited by
Sorted by citations
Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight.
Taylor, S. E., Klein, L. C., Lewis, B. P., Gruenewald, T. L., Gurung, R. A. R., & Updegraff, J. A. (2000) · Psychological Review · doi:10.1037/0033-295x.107.3.411 · Cited by 3,308
“We suggest that these patterns may have evolved according to principles of natural selection and by virtue of differential parental investment.”
BackgroundOxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
“More recently, Melis and coworkers (Melis et al., 2007) found that: (1) injections of both the Oxt receptor antagonist CPOVT and the dopamine receptor antagonist haloperidol into the shell of the NAcc or the PVN abolishes Oxt-induced penile erections; (2) injections of Oxt into the ventral tegmental area (VTA) increas…”
InfluentialOxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689
“…oxytocin-administered ICV has been shown to induce stereotypic behaviors such as stretching, repetitive grooming, startle, and squeaking in mice (Drago et al, 1986; Insel and Winslow, 1991; Meisenberg and Simmons, 1983a; Nelson and Alberts, 1997), grooming, particularly of the genital regions,…”
BackgroundInsel, T. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90073-g · Cited by 487
Argiolas, A., & GESSA, G. L. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80002-8 · Cited by 366
Metadata
- Authors
- Drago, F., Pedersen, C. A., Caldwell, J. D., & Prange, A. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Drago, Filippo
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1986-03
- Volume
- 368
- Issue
- 2
- Pages
- 287-295
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2005322248
- Cited by
- 134
- References
- 48
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, grooming, dopamine, haloperidol, naloxone, intracerebroventricular administration, dose-response relationship, rats
- MeSH terms
- Animals, Female, Grooming, Haloperidol, Injections, Intraperitoneal, Injections, Intraventricular, Injections, Subcutaneous, Male, Naloxone, Oxytocin, Rats, Inbred Strains, Sex Characteristics, Time Factors, Rats
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