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Oxytocin potently enhances novelty-induced grooming behavior in the rat
Abstract
Intracerebroventricular (i.c.v.) injection of oxytocin was followed by an enhancement of novelty-induced grooming in male and female rats. This effect was dose-dependent, in a dose range of 0.1-10 micrograms. Grooming activity of rats injected i.c.v. with 10 micrograms of oxytocin was 9-fold higher than that of saline-injected controls. The analysis of behavioral element composition revealed an increased occurrence of genital grooming in oxytocin-injected rats. A time-course study revealed a sustained increase in grooming activity of oxytocin-treated rats during 45 min of behavioral testing. Intraperitoneal (i.p.) injection of the dopamine antagonist, haloperidol, totally suppressed oxytocin-enhanced grooming. Furthermore, i.p. injection of the opiate receptor antagonist, naloxone, was followed by an attenuation but not a suppression of grooming enhanced by i.c.v. administration of oxytocin. In addition, a small but significant increase in grooming activity was observed after subcutaneous injection of oxytocin. These results suggest that oxytocin-enhanced grooming behavior involves central mechanisms, e.g. dopamine and opioid transmission in the brain.
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“in rats OXT-enhanced grooming is attenuated by the opiate antagonist naloxone”
From An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits (2014) · cites this paper as Drago et al, 1986
In the citing paper
“suggesting that an interplay between OXT and endorphins may have contributed to the observed pattern of effects.”
From An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits (2014) · cites this paper as Drago et al, 1986
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“(9, 10), grooming (11), and the stress response (12, 13).”
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“Elevated central OXT levels are known to induce self-grooming of the facial, truncal, and genital areas in rodents (Amico et al., 2004; Caldwell et al., 1986; Drago et al., 1986), which can be blocked by OXTR antagonists (Amico et al.”
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“OT also functions to regulate the stress response (Kalin et al., 1985; Heinrichs et al., 2003;Amicoetal.,2004a),sexualbehaviors(Arletti etal.,1992; Kruger et al., 2003; Argiolas and Melis, 2004), aggressive behaviors (Winslow and Insel, 1991a; Harmon et al., 2002) and grooming, particularly allogrooming ( Drago et al.…”
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Tan, O., Musullulu, H., Raymond, J. S., Wilson, B. B., Langguth, M., & Bowen, M. T. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.016 · Cited by 59
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“Although Drago et al. (1986) did an i.c.v. OT dose– response curve, we did not do so with CeA microinjections, but used the optimal dose utilized by these authors, which was clearly effective in the current induction of hypergrooming and as said above, this hypergrooming was also blocked…”
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“CENTRALLY RELEASED OXYTOCIN (OT) is involved in processes that include maternal (50) and affiliative behavior (13, 71), lordosis (6), ingestion of food (64) and sodium chloridecontaining solutions (1, 3, 52, 60, 63), social memory (22, 23), and grooming (18).”
Drago, F., Caldwell, J. D., Pedersen, C. A., Continella, G., Scapagnini, U., & Prange, A. J. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90168-1 · Cited by 45
Self-citationCentrally administered oxytocin elicits exaggerated grooming in oxytocin null mice
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“Oxytocin is believed to be the core biological chemical that facilitates mother–infant attachment (Drago et al., 1986; Preston, 2013).”
Neonatal stress transiently alters the development of hippocampal oxytocin receptors
Noonan, L. R., Caldwell, J. D., Li, L., Walker, C. H., Pedersen, C. A., & Mason, G. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90094-9 · Cited by 42
Self-citationTransport of estrogen-induced oxytocin receptors in the ventromedial hypothalamus
Coirini, H., Schumacher, M., Flanagan, L., & McEwen, B. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03317.1991 · Cited by 40
“Thus, OT is involved in the regulation of many other central mechanisms (Fahrbach et al., 198 5; Drago et al., 1986; Argiolas et al., 1988; Arletti et al., 1989).”
BackgroundVasopressin modulates male squirrel monkeys' behavior during social separation
Winslow, J., & Insel, T. R. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90671-c · Cited by 38
The “low-dose” concept and the paradoxical effects of prolactin on grooming and sexual behavior
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Self-citation1-Oleoyl Lysophosphatidic Acid: A New Mediator of Emotional Behavior in Rats
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A comparison of grooming behavior potencies of neurohypophyseal nonapeptides
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“In other animal models, reduced oxytocin has also been shown to increase the frequency of grooming [97,98] and wing flapping [99].”
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Caldwell, J. D., Mason, G., Stanley, D. A., Jerdack, G. R., Hruby, V. J., Hill, P. S., Prange, A. J., & Pedersen, C. A. (1987) · Regulatory Peptides · doi:10.1016/0167-0115(87)90011-5 · Cited by 33
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Initiation of self-grooming in resting rats by local PVH infusion of oxytocin but not α-MSH
van Erp, A. M. M., Kruk, M. R., Semple, D. M., & Verbeet, D. W. P. (1993) · Brain Research · doi:10.1016/0006-8993(93)91494-d · Cited by 31
Oxytocin and cholecystokinin induced grooming behavior in the ventral tegmentum of the rat
Kaltwasser, M.-T., & Crawley, J. N. (1987) · Brain Research · doi:10.1016/0006-8993(87)90418-5 · Cited by 31
Johns, J. M., Lubin, D. A., Walker, C. H., Joyner, P., Middleton, C., Hofler, V. E., & McMurray, M. S. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.03.002 · Cited by 30
“…be altered by both cocaine and by manipulation of each of the aforementioned neurotransmitter systems (Rosenberg et al., 1977; Honda et al., 1985; Drago et al., 1986; Giordano et al., 1990; Kovacs et al., 1990; Cunningham et al., 1992; Kendrick et al., 1992; Sarnyai et al., 1992; Hansen, 1994;…”
BackgroundOvarian Steroid Modulation of Oxytocin Receptor Binding in the Ventromedial Hypothalamus
Schumacher, M., Coirini, H., Flanagan‐Cato, L. M., Frankfurt, M., Pfaff, D. W., & McEwen, B. S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34368.x · Cited by 30
Affiliation, Social Support, and Biobehavioral Responses to Stress
Taylor, S. E., Klein, L. C., Gruenewald, T. L., Gurung, R. A. R., & Fernandes‐Taylor, S. (2003) · doi:10.1002/9780470753552.ch12 · Cited by 28
Boer, G. J., Quak, J., de Vries, M. C., & Heinsbroek, R. P. W. (1994) · Peptides · doi:10.1016/0196-9781(94)90007-8 · Cited by 27
Oxytocin: Neurobiologic considerations and their implications for affective illness
Demitrack, M. A., & Gold, P. W. (1988) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(88)90072-3 · Cited by 26
Neonatal administration of oxytocin increases novelty-induced grooming in the adult rat
Noonan, L. R., Continella, G., & Pedersen, C. A. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90386-9 · Cited by 24
Ventral tegmental oxytocin induces grooming
Stivers, J. A., Kaltwasser, M.-T., Hill, P. S., Hruby, V. J., & Crawley, J. N. (1988) · Peptides · doi:10.1016/0196-9781(88)90248-3 · Cited by 23
Acute cocaine treatment decreases oxytocin levels in the rat hippocampus
Johns, J. M., Caldwell, J. D., & Pedersen, C. A. (1993) · Neuropeptides · doi:10.1016/0143-4179(93)90081-k · Cited by 24
Self-citationTan, O., Martin, L. J., & Bowen, M. T. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120913150 · Cited by 20
“This finding is consistent with previous work in rodents demonstrating OXT increases grooming via actions at the OXTR (Drago et al., 1986, 1991) and, specifically, through acting within various parts of a grooming circuit, including the PVN and central amygdala (Marroni et al., 2007; Van Erp et…”
BackgroundResultLeung, M., Yu, J., & Chong, A. M. L. (2015) · Journal of Construction Engineering and Management · doi:10.1061/(asce)co.1943-7862.0001059 · Cited by 22
Peterson, G., Mason, G., Barakat, A. S., & Pedersen, C. A. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.3.470 · Cited by 21
Self-citationDrago, F., Stanciu, M., Salehi, S., & Scapagnini, U. (1997) · Peptides · doi:10.1016/s0196-9781(97)00203-9 · Cited by 21
Self-citationIs oxytocin-induced grooming mediated by uterine-like receptors?
Caldwell, J. D., Hruby, V. J., Hill, P., Prange, A. J., & Pedersen, C. A. (1986) · Neuropeptides · doi:10.1016/0143-4179(86)90068-5 · Cited by 21
Self-citationIn Search of an Adult Attachment Stress Provocation to Measure Effect on the Oxytocin System
Munro‐Kramer, M. L., Brown, S. L., Pournajafi‐Nazarloo, H., Carter, C. S., Lopez, W. D., & Seng, J. S. (2013) · Journal of the American Psychiatric Nurses Association · doi:10.1177/1078390313492173 · Cited by 21
Laviola, G., Busdraghi, L. M., Meschino, G. J., Petrella, C., & Fiore, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22095039 · Cited by 19
“Actually, pre-test administration of oxytocin significantly increased the rate of self-grooming in all subjects, which is in accordance with the reported oxytocin augmented rate following intracerebral injections in rats [85,86].”
ResultThe inhibition of oxytocin-induced grooming by a specific receptor antagonist
Drago, F., Sarnyai, Z., & D’Agata, V. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90541-u · Cited by 16
Self-citationMattie Tops, A. (2014) · Psychological Inquiry · doi:10.1080/1047840x.2014.916194 · Cited by 16
Grados, M. A., Prazak, M. D., Saif, A., & Halls, A. J. M. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2016.1103225 · Cited by 16
The Season for Peace: Reconciliation in a Despotic Species (Lemur catta)
Palagi, E., & Norscia, I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142150 · Cited by 18
Intranasal Oxytocin Failed to Affect Chimpanzee (Pan troglodytes) Social Behavior
Proctor, D. P., Calcutt, S. E., Burke, K., & de Waal, F. Β. Μ. (2016) · Animal Behavior and Cognition · doi:10.12966/abc.04.08.2016 · Cited by 14
Effects of oxytocin on emotional stress and stress-induced gastric lesions
Grassi, M., & Drago, F. (1993) · Journal of Physiology-Paris · doi:10.1016/0928-4257(93)90014-k · Cited by 14
Self-citationEguibar, J. R., Cortés, C. M. A. C., Isidro, O., & Ugarte, A. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.04.009 · Cited by 13
Gargiulo, P. Á., & Donoso, A. O. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90047-6 · Cited by 13
Social impairments among children perinatally exposed to oxytocin or oxytocin receptor antagonist
Friedlander, E., Feldstein, O., Mankuta, D., Yaari, M., Harel‐Gadassi, A., Ebstein, R. P., & Yirmiya, N. (2017) · Early Human Development · doi:10.1016/j.earlhumdev.2017.01.008 · Cited by 13
van Erp, A. M. M., Kruk, M. R., van Oers, H. J. J., & Hemmers, N. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91251-m · Cited by 12
Cohen, L. B., & Lansing, A. H. (2021) · Springer eBooks · doi:10.1007/978-3-030-81245-4_3 · Cited by 15
Pantouli, F., Pujol, C., Derieux, C., Fonteneau, M., Pellissier, L. P., MARSOL, C., Karpenko, J., Bonnet, D., Hibert, M., Bailey, A., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01915-1 · Cited by 11
van Erp, A. M. M., Kruk, M. R., & de Kloet, E. R. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90776-e · Cited by 11
Metadata
- Authors
- Drago, F., Pedersen, C. A., Caldwell, J. D., & Prange, A. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Drago, Filippo
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1986-03
- Volume
- 368
- Issue
- 2
- Pages
- 287-295
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2005322248
- Cited by
- 134
- References
- 48
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, grooming, dopamine, haloperidol, naloxone, intracerebroventricular administration, dose-response relationship, rats
- MeSH terms
- Animals, Female, Grooming, Haloperidol, Injections, Intraperitoneal, Injections, Intraventricular, Injections, Subcutaneous, Male, Naloxone, Oxytocin, Rats, Inbred Strains, Sex Characteristics, Time Factors, Rats
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