Cited by 166Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorPharmacological Receptor Mechanisms and Effects

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Motivational properties of opioids: evidence that an activation of σ-receptors mediates reinforcement processes

Shippenberg, T.S., Bals-Kubik, R., Herz, A.·1987·Brain Research

DOI 10.1016/0006-8993(87)91667-2

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Abstract

The role of central delta-opioid receptors in the mediation of opioid reinforcement and endogenous reward processes was examined using a non-biased place-preference conditioning procedure. Intracerebroventricular (i.c.v.) administration of the selective delta-receptor agonist, [D-Pen2, D-Pen5]-enkephalin (DPDPE, 10.0-25.0 micrograms) produced a significant preference for the drug-associated place and a similar effect was observed following i.c.v. injections of morphine (10.0 micrograms). Administration of the delta-receptor antagonist, ICI 174,864, at doses (1.0-5.0 micrograms, i.c.v.) which had no aversive effects when tested alone, abolished the reinforcing properties of DPDPE. Such treatment did not, however, modify the effect of morphine. These findings demonstrate the involvement delta- as well as mu-receptors in the motivational properties of opioids and suggest that the activation of either receptor type is sufficient for the elicitation of appetitively reinforcing effects.

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Authors: Shippenberg, T. S., Bals-Kubik, R., & Herz, A.
Affiliations: Max Planck Institute of Psychiatry (DE)
Corresponding author: Shippenberg, T.S.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1987-12
Volume: 436
Issue: 2
Pages: 234-239
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(87)91667-2
OpenAlex: W2084913220
Cited by: 166
References: 22
Citations by year: 2025: 1 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 5
FWCI: 2.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Receptor Mechanisms and Effects
Keywords: delta opioid receptor, opioid reinforcement, place preference, morphine, DPDPE, ICI 174,864, mu-opioid receptor, intracerebroventricular administration
MeSH terms: Animals, Appetitive Behavior, Avoidance Learning, Enkephalin, Leucine, Enkephalins, Injections, Intraventricular, Male, Morphine, Motivation, Rats, Inbred Strains, Receptors, Opioid, Reinforcement, Psychology, Receptors, Opioid, delta, Enkephalin, D-Penicillamine (2,5)-, Rats

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Motivational properties of opioids: evidence that an activation of σ-receptors mediates reinforcement processes

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