Cited by 245Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

Self-administration of methionine enkephalin into the nucleus accumbens

Goeders, Nick E., Lane, John D., Smith, James E.·1984·Pharmacology Biochemistry and Behavior

Abstract

Microinfusions of the endogenous opiate neurohumor, methionine enkephalin, into the nucleus accumbens initiated a reinforcing stimulus in a dose-related manner. The reinforcing nature of this intracranial self-administration was evaluated with intermittent schedules of reinforcement and a two-lever discrimination procedure. Opiate receptors are likely responsible for the initiation of this reinforcing stimulus since naloxone effectively blocked self-administration. These data suggest the mediation of opiate reinforcement through interactions with opiate receptors in brain regions outside the ventral tegmental area, questioning the current dopamine hypothesis for the initiation of these reinforcement processes.

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Crossref · 10.1016/0091-3057(84)90284-3

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27 of 27 references verified0 citation errors · 0 not checkable

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Authors
Goeders, N. E., Lane, J. D., & Smith, J. E.
Affiliations
Louisiana State University Health Sciences Center Shreveport (US)
Corresponding author
Goeders, Nick E.
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1984-03
Volume
20
Issue
3
Pages
451-455
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2026970523
Cited by
245
References
27
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 2 · 2018: 3 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 3
FWCI
3.07
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Public Health Service
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
met-enkephalin, nucleus accumbens, opioid receptors, naloxone, dopamine hypothesis, endogenous opioids
MeSH terms
Animals, Behavior, Animal, Dose-Response Relationship, Drug, Enkephalin, Methionine, Humans, Male, Microinjections, Naloxone, Nucleus Accumbens, Rats, Inbred F344, Receptors, Opioid, Self Administration, Septal Nuclei, Receptors, Opioid, delta, Substance-Related Disorders, Rats

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