Self-administration of methionine enkephalin into the nucleus accumbens
Abstract
Microinfusions of the endogenous opiate neurohumor, methionine enkephalin, into the nucleus accumbens initiated a reinforcing stimulus in a dose-related manner. The reinforcing nature of this intracranial self-administration was evaluated with intermittent schedules of reinforcement and a two-lever discrimination procedure. Opiate receptors are likely responsible for the initiation of this reinforcing stimulus since naloxone effectively blocked self-administration. These data suggest the mediation of opiate reinforcement through interactions with opiate receptors in brain regions outside the ventral tegmental area, questioning the current dopamine hypothesis for the initiation of these reinforcement processes.
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Activation of MOR in the VTA, and DOR in the nucleus accumbens, is directly rewarding in rats, producing conditioned place preferences.
“Activation of MOR in the VTA, and DOR in the NAC, is directly rewarding in rats, producing conditioned place preferences (Goeders et al 1984; Olmstead and Franklin 1997b).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Goeders et al 1984
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- Authors
- Goeders, N. E., Lane, J. D., & Smith, J. E.
- Affiliations
- Louisiana State University Health Sciences Center Shreveport (US)
- Corresponding author
- Goeders, Nick E.
- ORCID
- Smith, James E.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1984-03
- Volume
- 20
- Issue
- 3
- Pages
- 451-455
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2026970523
- Cited by
- 245
- References
- 27
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 2 · 2018: 3 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- met-enkephalin, nucleus accumbens, opioid receptors, naloxone, dopamine hypothesis, endogenous opioids
- MeSH terms
- Animals, Behavior, Animal, Dose-Response Relationship, Drug, Enkephalin, Methionine, Humans, Male, Microinjections, Naloxone, Nucleus Accumbens, Rats, Inbred F344, Receptors, Opioid, Self Administration, Septal Nuclei, Receptors, Opioid, delta, Substance-Related Disorders, Rats
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