The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease
Open accessAbstract
Loss of dopaminergic neurons from the pars compacta of the substantia nigra is the pathological hallmark of Parkinson's disease (PD) and results in a partial deafferentation to the striatum. Since deafferentation is known to induce transynaptic atrophy of postsynaptic cells, we examined by Golgi impregnation the morphology of medium spiny I (MSI) striatal neurons, the principal target population for both nigrostriatal and corticostriatal fibers. Our quantitative data indicate that the dendritic arbor of MSI neurons in the putamen is significantly reduced in both length and number and MSI neurons are morphologically characterized by truncated dendrites with few dendritic spines and irregular, bulbous swellings. These data provide morphological evidence for the atrophy of striatal dendrites in PD and may explain, in part, the declining efficacy of chronic L-DOPA replacement therapy in advanced PD.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“While an important question in exercise yet to be fully addressed in PD and its animal models, studies in healthy rodents subjected to different exercise paradigms have demonstrated experience-dependent increases in dendritic spine density in a number of regions including the hippocampus and cerebellum 70, 94.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [94]
Citations
Cites
FRONTAL LOBE DYSFUNCTION IN PARKINSON'S DISEASE
TAYLOR, A. E., Saint‐Cyr, J. A., & Lang, A. E. (1986) · Brain · doi:10.1093/brain/109.5.845 · Cited by 887
Freund, T. F., Powell, J. F., & Smith, A. D. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90294-x · Cited by 875
THE CORTICO-STRIATE PROJECTION IN THE MONKEY
Kemp, J. M., & Powell, T. P. S. (1970) · Brain · doi:10.1093/brain/93.3.525 · Cited by 798
Wilson, C. J., & Groves, P. M. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901940308 · Cited by 527
Bouyer, J. J., Park, D. H., JOH, T. H., & Pickel, V. M. (1984) · Brain Research · doi:10.1016/0006-8993(84)90239-7 · Cited by 472
Anterograde and Retrograde Transneuronal Degeneration in the Central and Peripheral Nervous System
Cowan, W. M. (1970) · Springer eBooks · doi:10.1007/978-3-642-85986-1_11 · Cited by 465
The striatal cholinergic interneuron: Synaptic target of dopaminergic terminals?
Lehmann, J. C., & Langer, S. Z. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90102-1 · Cited by 429
A Golgi study of neuronal types in the neostriatum of monkeys
DiFiglia, M., Pasik, P., & Pasik, T. (1976) · Brain Research · doi:10.1016/0006-8993(76)90669-7 · Cited by 366
Contemporary Research Methods in Neuroanatomy
Grover, F. S. (1971) · Physical Therapy · doi:10.1093/ptj/51.11.1266a · Cited by 327
The site of termination of afferent fibres in the caudate nucleus
Kemp, J. M., & Powell, T. P. S. (1971) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1971.0104 · Cited by 324
Flagged first, then by citations
1 of the 32 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Moyer, 1985, Inexpensive PC based system for quantification of neuronal processes, Soc. Neurosci., 11, 261.18
Cited by
Sorted by citations
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,579
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203
Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
Fiala, J. C., Spacek, J., & Harris, K. M. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00158-3 · Cited by 811
Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798
Day, M., Wang, Z., Ding, J., An, X., Ingham, C. A., Shering, A. F., Wokosin, D., Ilijic, E., Sun, Z., Sampson, A. R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1632 · Cited by 745
Metadata
- Authors
- McNeill, T. H., Brown, S. A., Rafols, J. A., & Shoulson, I.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- McNeill, Thomas H.
- ORCID
- Shoulson, Ira
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1988-07
- Volume
- 455
- Issue
- 1
- Pages
- 148-152
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2069550409
- Cited by
- 246
- References
- 32
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 6 · 2023: 12 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 12 · 2018: 6 · 2017: 12 · 2016: 7 · 2015: 13 · 2014: 10 · 2013: 10 · 2012: 9
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-05445, AG03644)
- National Institute of Neurological Disorders and Stroke (NS17978)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Parkinson's disease, medium spiny neurons, dendritic atrophy, deafferentation, putamen, dendritic spines, substantia nigra, L-dopa therapy, neuronal morphology
- MeSH terms
- Aged, Aged, 80 and over, Atrophy, Corpus Striatum, Dendrites, Humans, Neurons, Parkinson Disease, Reference Values
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
