Cited by 27Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Dystrophic peptidergic neurites in senile plaques of Alzheimer's disease hippocampus precede formation of paired helical filaments

Lenders, Marie-Berthe, Peers, Marie-Claire, Tramu, Gérard, Delacourte, André, Defossez, André, Petit, Henri, Mazzuca, Marc·1989·Brain Research

Abstract

The relationship between peptidergic dystrophic neurites and paired helical filament (PHF)-positive neurites in Alzheimer's disease (AD) senile plaques (SPs) was studied using combined fluorescence and bright-field optics. Cryostat sections of AD hippocampi were first stained with thioflavine-S and immunolabelled with antisera raised against different neuropeptides: somatostatin-28(1-12), somatostatin-14, neuropeptide Y, cholecystokinin (CCK) and substance P. Secondly, using the elution-restaining procedure, sections were immunolabelled with anti-tau/PHF. In immature SPs, clusters of abnormal, swollen neurites were found. The dystrophic, strongly peptidic-positive neurites contained fewer PHFs than the poorly positive ones. Cell bodies, exhibiting a peptidic content, could be found within SPs without any alteration. These results suggest the following sequence of events: an extracellular poisoning mechanism, perhaps the amyloid substance, first changes the structure of presynaptic endings and causes the formation of ballooning dystrophic neurites filled with their normal peptidic content. Subsequently, intracellular degradation occurs with formation of the PHFs. Then the other structures such as dendrites and perikarya are damaged by the same mechanism. Therefore, this phenomenon seems to precede any formation of PHFs in SPs.

Integrity signals

Registry

Crossref · 10.1016/0006-8993(89)90812-3

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • NPs represent a nidus in which extracellular plaque substance(s) seem to induce intracellular degenerative changes with tau pathology.

    “The particular toxic substance(s) within NPs still have not been completely characterized (90, 103, 278), but NPs represent a nidus in which extracellular plaque substance(s) seem to induce intracellular degenerative changes with tau pathology (18, 50, 279-281).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lenders, M.-B., Peers, M.-C., Tramu, G., Delacourte, A., Defossez, A., Petit, H., & Mazzuca, M.
Affiliations
  • Centre Hospitalier Universitaire de Lille (FR)
  • Inserm (FR)
Corresponding author
Delacourte, André
Venue
Brain Research
Publisher
Elsevier BV
Published
1989-03
Volume
481
Issue
2
Pages
344-349
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2056895835
Cited by
27
References
34
Citations by year
2023: 1 · 2022: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2012: 2
FWCI
1.81
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, amyloid plaques, paired helical filaments, dystrophic neurites, hippocampus, somatostatin, neuropeptide Y, cholecystokinin, substance P, tau protein, amyloid, pathogenesis
MeSH terms
Alzheimer Disease, Cytoskeleton, Dendrites, Hippocampus, Humans, Immunohistochemistry, Intermediate Filaments, Microtubule-Associated Proteins, Neuropeptides, tau Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review