Quantitative assessment of the density of neurofibrillary tangles and senile plaques in senile dementia of the Alzheimer type. Comparison of immunocytochemistry with a specific antibody and Bodian’s protargol method.
Abstract
Counts of neurofibrillary tangles and senile plaques were performed in two adjacent sections from the temporal lobe in 14 women aged over 75 years at death. The mental status of these cases had been prospectively assessed by the test score of Blessed, Tomlinson and Roth. They were either intellectually normal or had senile dementia of the Alzheimer type of various degrees of severity. The first section was silver-impregnated according to Bodian's method; the second one was immunolabeled with an antiserum raised against neurofibrillary tangles. Densities of neurofibrillary tangles and senile plaques evaluated by the two techniques were highly correlated but their means of differences and limits of agreement were large. The correlation with the clinical data was similar for the two methods. Both techniques can thus be used with the same accuracy in correlative studies but their results are not interchangeable without caution.
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Compared with cortical amyloid-β plaque, the density and distribution of phosphorylated tau aggregated in neurofibrillary tangles correlate more closely with Alzheimer disease-associated cognitive impairment and neurodegeneration.
“Compared with cortical Aβ plaque, the density and distribution of phosphorylated tau aggregated in NFTs correlate more closely with AD-associated cognitive impairment and neurodegeneration.12,13,14”
From Positron Emission Tomography Imaging With [ <sup>18</sup> F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes (2020) · cites this paper as [13]
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- Authors
- Duyckaerts, C., Brion, J. P., Hauw, J. J., & Flament-Durand, J.
- Affiliations
- Pitié-Salpêtrière Hospital (FR)
- Université Libre de Bruxelles (BE)
- Venue
- Acta Neuropathologica
- Published
- 1987
- Volume
- 73
- Issue
- 2
- Pages
- 167-170
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2037473016
- Cited by
- 89
- References
- 23
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 2 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neurofibrillary tangles, amyloid plaques, Alzheimer's disease, senile dementia, temporal lobe, immunocytochemistry, silver staining, method comparison
- MeSH terms
- Aged, Alzheimer Disease, Female, Histocytochemistry, Humans, Immunologic Techniques, Indoles, Neurofibrils, Staining and Labeling
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