Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: Coexistence with neuropeptide Y neurons, and effects alzheimer‐type dementia

Chan‐Palay, V.

doi:10.1002/cne.902600205

Cited by 254Neuropeptides and Animal PhysiologyAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: Coexistence with neuropeptide Y neurons, and effects alzheimer‐type dementia

Chan‐Palay, V.·1987·Journal of Comparative Neurology

DOI 10.1002/cne.902600205

Open this paper in CoChat — free account

Abstract

The distribution of somatostatinlike immunoreactivity was studied in the hippocampal formation, retrohippocampal region, and temporal cortex in the human brain. Tissues from surgical biopsy and postmortem cases were used, and the immunogold/silver method on vibratome sections was introduced for routine applications in conjunction with primary antisera that recognise somatostatin‐14 or somatostatin‐28. Somatostatin‐28 antisera readily stained numerous neurons, dendrites, and extensive axonal networks throughout the hippocampus and neighbouring cortex. Liquid phase absorption provided controls for specificity. The most prominent accumulations of Somatostatin immunoreactive neurons and axons occurred in the hilus of the area dentata, in CA1, and in the entorhinal and perirhinal cortices. Axonal plexuses occurred throughout the hippocampal subfields but were particularly dense in those regions rich in Somatostatin neurons. The distribution of Somatostatin immunoreactive neurons and fibers parallels the distribution of neuropeptide Y (NPY) neurons and fibers in the hippocampus and cerebral cortex to a remarkable extent. Double labelling experiments with antisera against neuropeptide Y and Somatostatin indicate a considerable frequency of coexistence of the two peptides in single neurons, particularly in large multipolar cortical neurons and also in the small bipolar white matter neurons. Regional variations exist in the amounts of coexistence found in the hippocampal subfields; somatostatin‐NPY coexistence is particularly high in the hilus of the area dentata, the subicular complex, and the deep layers of the entorhinal and perirhinal cortices. In the hippocampi and temporal cortices in cases of Alzheimer‐type dementia compared to those of age‐matched control brains, there is a significant to severe loss of Somatostatin immunoreactive neurons and axons. This loss is most severe in those regions with the highest indices of neurofibrillary tangles and neuritic plaques–the hilus of the area dentata, CA1, and the entorhinal and perirhinal cortices. Surviving Somatostatin neurons are distorted with short dendrites and truncated axons. Neuritic plaques identified on double label experiments with thioflavin include Somatostatin axons but not neurons.

Integrity signals

Registry

Crossref · 10.1002/cne.902600205

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Alzheimer's disease patients have a specific loss of somatostatin-positive interneurons in the cortex and hippocampus.
“Additionally, AD patients have a specific loss of somatostatin-positive interneurons in the cortex [94] and hippocampus [95].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [95]

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117 · see citing works
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627 · see citing works
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565 · see citing works
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
Brazeau, P., Vale, W., Burgus, R. C., LING, N. C., Butcher, M., Rivier, J., & Guillemin, R. (1973) · Science · doi:10.1126/science.179.4068.77 · Cited by 3,536 · see citing works
Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation
Coyle, J. T., Price, D. L., & DeLong, M. R. (1983) · Science · doi:10.1126/science.6338589 · Cited by 3,050 · see citing works
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499 · see citing works
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268 · see citing works
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084 · see citing works
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.
Perry, E., Tomlinson, B. E., Blessed, G., Bergmann, K., Gibson, P., & Perry, R. H. (1978) · British medical journal · doi:10.1136/bmj.2.6150.1457 · Cited by 2,043 · see citing works
Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study
Swanson, L. W., Sawchenko, P. E., Rivier, J., & Vale, W. W. (2008) · Neuroendocrinology · doi:10.1159/000123454 · Cited by 1,953 · see citing works
The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine‐ B ‐hydroxylase as a marker
Swanson, L. W., & Hartman, B. K. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901630406 · Cited by 1,479 · see citing works
NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES
Bowen, D. M., Smith, C. B., White, P., & DAVISON, A. N. (1976) · Brain · doi:10.1093/brain/99.3.459 · Cited by 1,313 · see citing works
Greenfield's Neuropathology
Lantos, P. L. (1985) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.48.5.496 · Cited by 1,154 · see citing works
THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS
Shute, C. C. D., & Lewis, P. R. (1967) · Brain · doi:10.1093/brain/90.3.497 · Cited by 1,120 · see citing works
Neuropeptide Y Distribution in the Rat Brain
Allen, Y. S., Adrian, T. E., Allen, J. M., Tatemoto, K., Crow, T. J., Bloom, S. R., & Polak, J. M. (1983) · Science · doi:10.1126/science.6136091 · Cited by 1,097 · see citing works
The anatomy of neuropeptide-y-containing neurons in rat brain
Chronwall, B. M., DiMaggio, D. A., Massari, V. J., Pickel, V. M., Ruggiero, D. A., & O’Donohue, T. L. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90260-x · Cited by 1,088 · see citing works
NECROPSY EVIDENCE OF CENTRAL CHOLINERGIC DEFICITS IN SENILE DEMENTIA
Perry, E., Perry, R., Blessed, G., & Tomlinson, B. E. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91780-9 · Cited by 1,070 · see citing works
Distribution of cholinergic neurons in rat brain: Demonstrated by the immunocytochemical localization of choline acetyltransferase
Armstrong, D. M., Saper, C. B., Levey, A. I., Wainer, B. H., & Terry, R. D. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902160106 · Cited by 970 · see citing works
A golgi study of cell types in the hilar region of the hippocampus in the rat
Amaral, D. G. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901820508 · Cited by 911 · see citing works
Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa
Davies, P., Katzman, R., & Terry, R. D. (1980) · Nature · doi:10.1038/288279a0 · Cited by 882 · see citing works
An analysis of the origins of the cholinergic and noncholinergic septal projections to the hippocampal formation of the rat
Amaral, D. G., & Kurz, J. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902400104 · Cited by 687 · see citing works
Immunohistochemical distribution of somatostatin-like immunoreactivity in the central nervous system of the adult rat
Johansson, O., Hökfelt, T., & Elde, R. P. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90233-1 · Cited by 674 · see citing works
Plaques, tangles and dementia
Wilcock, G. K., & Esiri, M. M. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90155-1 · Cited by 608 · see citing works
Chemoarchitecture of the Brain
Nieuwenhuys, R. (1985) · Springer eBooks · doi:10.1007/978-3-642-70426-0 · Cited by 500 · see citing works
The immunocytochemical localization of somatostatin-containing neurons in the rat central nervous system
Finley, J. C. W., Maderdrut, J. L., ROGER, L. J., & Petrusz, P. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90006-3 · Cited by 491 · see citing works
Brain Peptides as Neurotransmitters
Snyder, S. H. (1980) · Science · doi:10.1126/science.6157191 · Cited by 487 · see citing works
Confirmation from choline acetylase analyses of a massive cholinergic innervation to the rat hippocampus
Lewis, P. R., Shute, C. C. D., & Silver, A. (1967) · The Journal of Physiology · doi:10.1113/jphysiol.1967.sp008246 · Cited by 473 · see citing works
Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain
McGeer, P. L., McGeer, E. G., Suzuki, J., DOLMAN, C. E., & Nagai, T. (1984) · Neurology · doi:10.1212/wnl.34.6.741 · Cited by 457 · see citing works
The Distribution of Adrenergic Nerve Fibres to the Blood Vessels in Skeletal Muscle
Fuxé, K., & Sedvall, G. (1965) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1965.tb04155.x · Cited by 419 · see citing works
The serotonin innervation of the cerebral cortex in the rat—an immunohistochemical analysis
Lidov, H. G. W., Grzanna, R., & Molliver, M. E. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90099-8 · Cited by 417 · see citing works
Chemoarchitecture of the brain
(1987) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(87)90305-7 · Cited by 416 · see citing works
Morphology, distribution, and synaptic relations of somatostatin- and neuropeptide Y-immunoreactive neurons in rat and monkey neocortex
Hendry, S., Jones, E. G., & Emson, P. C. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-10-02497.1984 · Cited by 415 · see citing works
Regulatory Peptides of the Hypothalamus
Vale, W., RIVIER, C. L., & Brown, M. (1977) · Annual Review of Physiology · doi:10.1146/annurev.ph.39.030177.002353 · Cited by 392 · see citing works
Calcium-dependent release of somatostatin and neurotensin from rat brain in vitro
Iversen, L. L., Iversen, S. D., Bloom, F. E., DOUGLAS, C., Brown, M., & Vale, W. (1978) · Nature · doi:10.1038/273161a0 · Cited by 350 · see citing works
Transmitter deficits in Alzheimer's disease
Hardy, J., Adolfsson, R., Alafuzoff, I. I., Bucht, G., Marcusson, J. O., Nyberg, P., Perdahl, E., Wester, P. O., & Winblad, B. G. (1985) · Neurochemistry International · doi:10.1016/0197-0186(85)90050-6 · Cited by 329 · see citing works
Biochemical changes in Dementia disorders of Alzheimer type (AD/SDAT)
Gottfries, C., Adolfsson, R., Aquilonius, S., Carlsson, A., Eckernäs, S. ‐., Nordberg, A. K., Oreland, L., Svennerholm, L. T., Wiberg, Å., & Winblad, B. G. (1983) · Neurobiology of Aging · doi:10.1016/0197-4580(83)90002-7 · Cited by 304 · see citing works
Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity.
McGinty, J. F., Henriksen, S. J., D, A. G. M., Terenius, L. Y., & Bloom, F. E. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.2.589 · Cited by 290 · see citing works
Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile Dementia of the Alzheimer type
Davies, P., & Terry, R. D. (1981) · Neurobiology of Aging · doi:10.1016/0197-4580(81)90053-1 · Cited by 274 · see citing works
Central somatostatin systems revealed with monoclonal antibodies
Vincent, S. R., McIntosh, C. H. S., Buchan, A. M. J., & Brown, J. C. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902380205 · Cited by 269 · see citing works
Changes in acetylcholinesterase and distribution of degenerating fibres in the hippocampal region after septal lesions in the rat
Mellgren, S. I., & Srebro, B. (1973) · Brain Research · doi:10.1016/0006-8993(73)90648-3 · Cited by 267 · see citing works
Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patients
Morrison, J. H., Rogers, J., Scherr, S., Benoit, R., & Bloom, F. E. (1985) · Nature · doi:10.1038/314090a0 · Cited by 264 · see citing works
Is somatostatin an excitatory transmitter in the hippocampus?
Dodd, J., & Kelly, J. S. (1978) · Nature · doi:10.1038/273674a0 · Cited by 264 · see citing works
Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study
Ball, M. J. (1978) · Acta Neuropathologica · doi:10.1007/bf00690970 · Cited by 251 · see citing works
Survival of basal ganglia neuropeptide Y-somatostatin neurones in Huntington's disease
Dawbarn, D., de Quidt, M. E., & Emson, P. C. (1985) · Brain Research · doi:10.1016/0006-8993(85)90921-7 · Cited by 251 · see citing works
A study of the reciprocal connections between the septum and the entorhinal area using anterograde and retrograde axonal transport methods in the rat brain
Alonso, Á., & Köhler, C. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902250303 · Cited by 243 · see citing works
The morphology and distribution of peptide-containing neurons in the adult and developing visual cortex of the rat. I. Somatostatin
McDonald, J. K., Parnavelas, J. G., Karamanlidis, A. N., Brecha, N. C., & Koenig, J. I. (1982) · Journal of Neurocytology · doi:10.1007/bf01153520 · Cited by 221 · see citing works
Immunohistochemical distribution of pro-somatostatin-related peptides in cerebral cortex
Morrison, J. H., Benoit, R., Magistretti, P. J., & Bloom, F. E. (1983) · Brain Research · doi:10.1016/0006-8993(83)91031-4 · Cited by 220 · see citing works
Cholecystokinin in hippocampal pathways
Greenwood, R., Godar, S. E., Reaves, T. A., & Hayward, J. N. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.902030303 · Cited by 219 · see citing works
Neuropeptides in Alzheimer type dementia
Ferrier, I. N., Cross, A. J., Johnson, J. A., Roberts, G. W., Crow, T. J., Corsellis, J., Lee, Y. C., O'Shaughnessy, D., Adrian, T. E., McGregor, G. P., et al. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90196-x · Cited by 215 · see citing works
Location of neuronal tangles in somatostatin neurones in Alzheimer's disease
Roberts, G. W., Crow, T. J., & Polak, J. M. (1985) · Nature · doi:10.1038/314092a0 · Cited by 213 · see citing works
Somatostatin hyperpolarizes hippocampal pyramidal cells in vitro
Pittman, Q. J., & Siggins, G. R. (1981) · Brain Research · doi:10.1016/0006-8993(81)90791-5 · Cited by 210 · see citing works
Primary structure of ovine hypothalamic somatostatin-28 and somatostatin-25.
Esch, F. S., Böhlen, P., LING, N. C., Benoit, R., Brazeau, P., & Guillemin, R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.11.6827 · Cited by 209 · see citing works
The limbic system in Alzheimer's disease. A neuropathologic investigation.
Hopper, M., & Vogel, F. S. (1976) · PubMed Central · Cited by 208 · see citing works
Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.
Schally, A. V., Huang, W. Y., Chang, R. C., Arimura, A., Redding, T. W., Millar, R. P., Hunkapiller, M. W., & Hood, L. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.8.4489 · Cited by 208 · see citing works
The substantia innominata in alzheimer's disease: an histochemical and biochemical study of cholinergic marker enzymes
Rossor, M. N., Svendsen, C. N., Hunt, S. P., Mountjoy, C. Q., Roth, M., & Iversen, L. L. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90155-0 · Cited by 202 · see citing works
Neuropeptide Y innervation of the hippocampal region in the rat and monkey brain
Köhler, C., Eriksson, L. G., Davies, S. W., & Chan‐Palay, V. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902440310 · Cited by 192 · see citing works
Self-citation
High affinity binding sites for a somatostatin-28 analog in rat brain
Reubi, J., Perrin, M. H., Rivier, J., et al. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90628-7 · Cited by 191 · see citing works
Receptor binding of somatostatin-28 is tissue specific
Srikant, C. B., & Patel, Y. (1981) · Nature · doi:10.1038/294259a0 · Cited by 187 · see citing works
Immunoreactive pancreatic polypeptide (PP) occurs in the central and peripheral nervous system: Preliminary immunocytochemical observations
Lor�n, I., Alumets, J., H�kanson, R., & Sundler, F. (1979) · Cell and Tissue Research · doi:10.1007/bf00236410 · Cited by 180 · see citing works
Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of alzheimer-type patients
Henke, H., & Lang, W. (1983) · Brain Research · doi:10.1016/0006-8993(83)90880-6 · Cited by 176 · see citing works
Distribution of neuropeptides in the limbic system of the rat: The hippocampus
Roberts, G. W., Woodhams, P. L., Polak, J. M., & Crow, T. J. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90214-8 · Cited by 174 · see citing works
Immunohistochemical distribution of pro-somatostatin-related peptides in hippocampus
Morrison, J. H., Benoit, R., Magistretti, P. J., LING, N. C., & Bloom, F. E. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90165-3 · Cited by 162 · see citing works
Presence of somatostatin-28-(1-12) in hypothalamus and pancreas.
Benoit, R., Böhlen, P., LING, N. C., Briskin, A. I., Esch, F. S., Brazeau, P., Ying, S. Y., & Guillemin, R. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.3.917 · Cited by 152 · see citing works
Monoamine metabolism in senile dementia of Alzheimer type
Cross, A. J., Crow, T. J., Johnson, J. A., Joseph, M. H., Perry, E. K., Perry, R. H., Blessed, G., & Tomlinson, B. E. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90149-1 · Cited by 150 · see citing works
Seven peptides derived from pro-somatostatin in rat brain
Benoit, R., LING, N. C., Alford, B., et al. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(82)90614-3 · Cited by 150 · see citing works
A diffuse αMSH‐immunoreactive projection to the hippocampus and spinal cord from individual neurons in the lateral hypothalamic area and zona incerta
Köhler, C., Haglund, L., & Swanson, L. W. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902230404 · Cited by 138 · see citing works
Neuropeptide Y: regional distribution chromatographic characterization and immunohistochemical demonstration in post-mortem human brain
Dawbarn, D., Hunt, S. P., & Emson, P. C. (1984) · Brain Research · doi:10.1016/0006-8993(84)90526-2 · Cited by 137 · see citing works
Characterization of the prodynorphin and proenkephalin neuropeptide systems in rat hippocampus
Chavkin, C., Shoemaker, W. J., McGinty, J. F., Bayón, A., & Bloom, F. E. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-03-00808.1985 · Cited by 133 · see citing works
Co-localization of neuropeptide tyrosine and somatostatin immunoreactivity in neurons of individual subfields of the rat hippocampal region
Köhler, C., Eriksson, L. G., Davies, S., et al. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90551-9 · Cited by 131 · see citing works
Central actions of somatostatin
Olpe, H.-R., Balcar, V. J., Bittiger, H., Rink, H., & Sieber, P. (1980) · European Journal of Pharmacology · doi:10.1016/0014-2999(80)90436-7 · Cited by 131 · see citing works
I. Cytology and distribution in normal human cerebral cortex of neurons immunoreactive with antisera against neuropeptide Y
Chan‐Palay, V., Allen, Y. S., Lang, W., et al. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902380403 · Cited by 130 · see citing works
Self-citation
Reduced cholinesterase activity and somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with dementia of the Alzheimer type
Soininen, H. S., Jolkkonen, J., Reinikainen, K. J., et al. (1984) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(84)90193-x · Cited by 116 · see citing works
Distribution of altered hippocampal neurons and axons immunoreactive with antisera against neuropeptide Y in Alzheimer's‐type dementia
Chan‐Palay, V., Lang, W., Haesler, U., Köhler, C., & Yasargil, G. M. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902480307 · Cited by 113 · see citing works
Self-citation
Somatostatin facilitates the serotonin release from rat cerebral cortex, hippocampus and hypothalamus slices
Tanaka, S., & Tsujimoto, A. (1981) · Brain Research · doi:10.1016/0006-8993(81)90636-3 · Cited by 109 · see citing works
Investigation of Cerebrospinal Fluid Neuropeptides in Idiopathic Senile Dementia
Oram, J. J., Edwardson, J. A., & Millard, P. H. (2009) · Gerontology · doi:10.1159/000212476 · Cited by 105 · see citing works
Elevation of neuropeptide Y (NPY) in substantia innominata in Alzheimer's type dementia
Allen, J. M., Ferrier, I. N., Roberts, G. W., et al. (1984) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(84)90180-1 · Cited by 104 · see citing works
Distribution of neurons and axons immunoreactive with antisera against neuropeptide Y in the normal human hippocampus
Chan‐Palay, V., Köhler, C., Haesler, U., Lang, W., & Yasargil, G. M. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902480306 · Cited by 97 · see citing works
Self-citation
Synaptic terminals with somatostatin-like immunoreactivity in the rat brain
Petrusz, P., Sar, M., Grossman, G., et al. (1977) · Brain Research · doi:10.1016/0006-8993(77)91024-1 · Cited by 95 · see citing works
Comparative localization of enkephalin and cholecystokinin immunoreactivities and heavy metals in the hippocampus
Stengaard‐Pedersen, K., Fredens, K., & Larsson, L. (1983) · Brain Research · doi:10.1016/0006-8993(83)91097-1 · Cited by 93 · see citing works
On the structure of the human archicortex
Braak, H. (1974) · Cell and Tissue Research · doi:10.1007/bf00223955 · Cited by 90 · see citing works
Somatostatin-like immunoreactivity within neuritic plaques
Armstrong, D. M., LeRoy, S., Shields, D., & Terry, R. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)90249-5 · Cited by 88 · see citing works
The distribution of somatostatin‐like immunoreactivity in the monkey hippocampal formation
Bakst, I., Morrison, J. H., & Amaral, D. G. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902360402 · Cited by 86 · see citing works
Somatostatin: Localization and distribution in the cortex and the subcortical white matter of human brain
Sørensen, K. V. (1982) · Neuroscience · doi:10.1016/0306-4522(82)91129-0 · Cited by 82 · see citing works
Somatostatin- and Neuropeptide Y-immunoreactive neurons in the neocortex in senile dementia of alzheimer's type
Nakamura, S., & Vincent, S. R. (1986) · Brain Research · doi:10.1016/0006-8993(86)91099-1 · Cited by 77 · see citing works
The distribution and orientation of serotonin fibers in the entorhinal and other retrohippocampal areas
K�hler, C., Chan‐Palay, V., & Steinbusch, H. W. M. (1981) · Anatomy and Embryology · doi:10.1007/bf00301824 · Cited by 77 · see citing works
Self-citation
The distribution of cholecystokinin‐like immunoreactive neurons and nerve terminals in the retrohippocampal region in the rat and guinea pig
Köhler, C., & Chan‐Palay, V. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902100204 · Cited by 73 · see citing works
Self-citation
S0MAT0STATIN-28tl-12)-LIKE IMMUNOREACTIVITY IN THE RAT
Benoit, R., LING, N. C., Bakhit, C., Morrison, J. H., Alford, B., & Guillemin, R. (1982) · Endocrinology · doi:10.1210/endo-111-6-2149 · Cited by 72 · see citing works
Supramammillary afferents to guinea pig hippocampus contain substance P-like immunoreactivity
Gall, C. M., & Selawski, L. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90546-9 · Cited by 68 · see citing works
Clinical Neurology of Aging
Poser, C. M. (1985) · JAMA · doi:10.1001/jama.1985.03350270124040 · Cited by 60 · see citing works
High molecular weight somatostatin secretion by cultured rat brain cells
Peterfreund, R. A., & Vale, W. (1982) · Brain Research · doi:10.1016/0006-8993(82)90522-4 · Cited by 59 · see citing works
Somatostatin and vasoactive intestinal polypeptide-like immunoreactive cells and terminals in the retrohippocampal region of the rat brain
K�hler, C., & Chan‐Palay, V. (1983) · Anatomy and Embryology · doi:10.1007/bf00298508 · Cited by 55 · see citing works
Self-citation
Depolarization- and Ionophore-Induced Release of Octacosa Somatostatin from Stalk Median Eminence Synaptosomes
Kewley, C. F., Millar, R. P., BERMAN, M. C., & Schally, A. V. (1981) · Science · doi:10.1126/science.6114560 · Cited by 54 · see citing works
Somatostatin-28 [1–12] — Like Peptides
Benoit, R., Böhlen, P., LING, N. C., Esch, F. S., Baird, A., Ying, S. Y., Wehrenberg, W. B., Guillemin, R., Morrison, J. H., Bakhit, C., et al. (1985) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-7886-4_6 · Cited by 52 · see citing works
Release of somatostatin-28(1–12) from rat hypothalamus in vitro
Bakhit, C., Benoit, R., & Bloom, F. E. (1983) · Nature · doi:10.1038/301524a0 · Cited by 49 · see citing works
A morphological analysis of vasoactive intestinal polypeptide (VIP)‐like immunoreactive neurons in the area dentata of the rat brain
Köhler, C. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902210302 · Cited by 49 · see citing works
Differing immunoreactivities of somatostatin in the cortex and the hypothalamus of the rat
Krisch, B. (1980) · Cell and Tissue Research · doi:10.1007/bf00236510 · Cited by 46 · see citing works
The substance P innervation of the rat hippocampal region
Davies, S., & K�hler, C. (1985) · Anatomy and Embryology · doi:10.1007/bf00707303 · Cited by 46 · see citing works
Origin of the neuropeptide Y innervation of the rat retrohippocampal region
Köhler, C., Śmiałowska, M., Eriksson, L. G., et al. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90276-4 · Cited by 31 · see citing works
Immunocytochemistry of human brain tissue with a polyclonal antiserum against neuropeptide Y
Chan‐Palay, V., & Yasargil, G. M. (1986) · Anatomy and Embryology · doi:10.1007/bf00318333 · Cited by 28 · see citing works
Self-citation
Somatostatin binding sites in various structures of the rat brain
Tapia‐Arancibia, L., Epelbaum, J., Enjalbert, A., et al. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90201-6 · Cited by 27 · see citing works

Flagged first, then by citations

Sorted by citations

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease
Najm, R., Jones, E. A., & Huang, Y. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0324-6 · Cited by 183 · see citing works
Parvalbumin-immunoreactive neurons in the hippocampal formation of Alzheimer’s diseased brain
Brady, D. R., & Mufson, E. J. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00068-7 · Cited by 125 · see citing works
Hippocampal Interneurons in Bipolar Disorder
Konradi, C., Zimmerman, E. I., Yang, C. K., Lohmann, K. M., Gresch, P., Pantazopoulos, H., Berretta, S., & Heckers, S. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.175 · Cited by 115 · see citing works
Calretinin Interneurons are Early Targets of Extracellular Amyloid-β Pathology in PS1/AβPP Alzheimer Mice Hippocampus
Baglietto-Vargas, D., Moreno-Gonzalez, I., Sanchez-Varo, R., Jimenez, S., Trujillo-Estrada, L., Sanchez-Mejias, E., Torres, M., Romero-Acebal, M., Ruano, D., Vizuete, M., et al. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100066 · Cited by 98 · see citing works
Structural organization of long-range GABAergic projection system of the hippocampus
Jinno, S. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.013.2009 · Cited by 75 · see citing works
Somatostatin, Olfaction, and Neurodegeneration
Saiz-Sanchez, D., Ubeda-Bañon, I., Flores-Cuadrado, A., Gonzalez-Rodriguez, M., Villar-Conde, S., Astillero-Lopez, V., & Martinez-Marcos, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00096 · Cited by 32 · see citing works
Dystrophic peptidergic neurites in senile plaques of Alzheimer's disease hippocampus precede formation of paired helical filaments
Lenders, M.-B., Peers, M.-C., Tramu, G., Delacourte, A., Defossez, A., Petit, H., & Mazzuca, M. (1989) · Brain Research · doi:10.1016/0006-8993(89)90812-3 · Cited by 27 · see citing works

Cutting Thick Sections Using a VibratomePreprint
Iulianella, A. (2017) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot094011 · Cited by 17 · see citing works
Precision vibratome for high-speed ultrathin biotissue cutting and organ-wide imaging
Li, Y., Ding, Z., Deng, L., Fan, G., Zhang, Q., Gong, H., Li, A., Yuan, J., & Chen, J. (2021) · iScience · doi:10.1016/j.isci.2021.103016 · Cited by 12 · see citing works
Comparison of Vibratome and Compresstome sectioning of fresh primate lymphoid and genital tissues for in situ MHC-tetramer and immunofluorescence staining
Abdelaal, H. M., Kim, H. O., Wagstaff, R. K., et al. (2015) · Biological Procedures Online · doi:10.1186/s12575-014-0012-4 · Cited by 23 · see citing works
Immunohistochemistry and In Situ mRNA Detection Using Inner Ear Vibratome Sections
Scheibinger, M., Janesick, A., Diaz, G. H., et al. (2022) · Neuromethods · doi:10.1007/978-1-0716-2022-9_3 · Cited by 6 · see citing works
Histochemical Detection of Horseradish Peroxidase Activity in the Rat by the Vibratome-Paraplast Method
Liem, R. S. B., Rokx, J. T. M., & van Willigen, J. D. (1988) · Cells Tissues Organs · doi:10.1159/000146569 · Cited by 2 · see citing works

Authors: Chan‐Palay, V.
Affiliations: University Hospital Zurich (CH)
Corresponding author: Chan‐Palay, V.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 1987-06-08
Volume: 260
Issue: 2
Pages: 201-223
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.902600205
OpenAlex: W2113861132
Cited by: 254
References: 100
Citations by year: 2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 2
FWCI: 7.78
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6333 d)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: Air Force Office of Scientific Research
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: somatostatin, neuropeptide Y, neuropeptide coexistence, hippocampus, temporal cortex, Alzheimer's disease, neurofibrillary tangles, neuritic plaques, somatostatin-28, somatostatin-14, entorhinal cortex, perirhinal cortex, CA1
MeSH terms: Adolescent, Adult, Alzheimer Disease, Cerebral Cortex, Child, Child, Preschool, Female, Hippocampus, Histological Techniques, Humans, Male, Middle Aged, Neurons, Neuropeptide Y, Silver, Somatostatin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: Coexistence with neuropeptide Y neurons, and effects alzheimer‐type dementia

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks