Cited by 219Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

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Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age

Ingham, C.A., Hood, S.H., Arbuthnott, G.W.·1989·Brain Research

DOI 10.1016/0006-8993(89)91686-7

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Abstract

Golgi-impregnated medium-size spiny neurones were studied in the rat neostriatum at various times after a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle. At both short (12-26 days) and long (7-12 months) survival times, the density of spines was significantly lower (13%) on neostriatal neurones ipsilateral to the 6-hydroxydopamine injection. At longer times the density of spines was lower on neurones both ipsilateral and contralateral to the lesion when compared to neurones taken from short-term animals (23%).

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Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb11000.x · Cited by 1,920
Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines
Freund, T. F., Powell, J. F., & Smith, A. D. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90294-x · Cited by 875
Demonstration and mapping out of nigro-neostriatal dopamine neurons
Andén, N. ‐., Carlsson, A., Dahlström, A. B., Fuxé, K., Hillarp, N. ‐., & Larsson, K. (1964) · Life Sciences · doi:10.1016/0024-3205(64)90161-4 · Cited by 812
Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.
Young, W. S., Bonner, T. I., & Brann, M. R. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9827 · Cited by 748
Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization
Hefti, F. F., Melamed, E., & Wurtman, R. J. (1980) · Brain Research · doi:10.1016/0006-8993(80)90871-9 · Cited by 504
Apical dendritic spines of the visual cortex and light deprivation in the mouse
Valverde, P. (1967) · Experimental Brain Research · doi:10.1007/bf00237559 · Cited by 483
Identification of synaptic terminals of thalamic or cortical origin in contact with distinct medium‐size spiny neurons in the rat neostriatum
Dubé, L., Smith, A. D., & Bolam, J. P. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902670402 · Cited by 333
The termination of fibres from the cerebral cortex and thalamus upon dendritic spines in the caudate nucleus: a study with the Golgi method
Kemp, J. M., & Powell, T. P. S. (1971) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1971.0105 · Cited by 306
Morphological Alterations in Hippocampus After Long-Term Alcohol Consumption in Mice
Riley, J. N., & Walker, D. W. (1978) · Science · doi:10.1126/science.566953 · Cited by 288

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Authors: Ingham, C. A., Hood, S. H., & Arbuthnott, G. W.
Affiliations: University of Edinburgh (GB)
Corresponding author: Ingham, C.A.
ORCID: Arbuthnott, G.W.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1989-12
Volume: 503
Issue: 2
Pages: 334-338
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(89)91686-7
OpenAlex: W2074379320
Cited by: 219
References: 38
Citations by year: 2025: 4 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 10 · 2018: 3 · 2017: 8 · 2016: 8 · 2015: 14 · 2014: 6 · 2013: 13 · 2012: 7
FWCI: 1.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: dendritic spine density, neostriatum, 6-hydroxydopamine lesion, medial forebrain bundle, striatal neurons, age-related changes, ipsilateral and contralateral effects, dopaminergic neurotoxicity, Golgi impregnation
MeSH terms: Aging, Animals, Corpus Striatum, Dendrites, Hydroxydopamines, Male, Medial Forebrain Bundle, Rats, Inbred Strains, Oxidopamine, Rats

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Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age

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