The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age
Abstract
Golgi-impregnated medium-size spiny neurones were studied in the rat neostriatum at various times after a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle. At both short (12-26 days) and long (7-12 months) survival times, the density of spines was significantly lower (13%) on neostriatal neurones ipsilateral to the 6-hydroxydopamine injection. At longer times the density of spines was lower on neurones both ipsilateral and contralateral to the lesion when compared to neurones taken from short-term animals (23%).
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“These morphological changes reflect the loss of synapses and hence reduction in neurotransmission not only in PD but a wide spectrum of brain disorders including Alzheimer’s disease and Fragile-X syndrome 91.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [91]
Citations
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Grissell, A. E., & Ariano, M. A. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-387-28066-9_27
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Metadata
- Authors
- Ingham, C. A., Hood, S. H., & Arbuthnott, G. W.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- Ingham, C.A.
- ORCID
- Arbuthnott, G.W.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1989-12
- Volume
- 503
- Issue
- 2
- Pages
- 334-338
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2074379320
- Cited by
- 219
- References
- 38
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 10 · 2018: 3 · 2017: 8 · 2016: 8 · 2015: 14 · 2014: 6 · 2013: 13 · 2012: 7
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- dendritic spine density, neostriatum, 6-hydroxydopamine lesion, medial forebrain bundle, striatal neurons, age-related changes, ipsilateral and contralateral effects, dopaminergic neurotoxicity, Golgi impregnation
- MeSH terms
- Aging, Animals, Corpus Striatum, Dendrites, Hydroxydopamines, Male, Medial Forebrain Bundle, Rats, Inbred Strains, Oxidopamine, Rats
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