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Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age

Ingham, C.A., Hood, S.H., Arbuthnott, G.W.·1989·Brain Research

DOI 10.1016/0006-8993(89)91686-7

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Abstract

Golgi-impregnated medium-size spiny neurones were studied in the rat neostriatum at various times after a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle. At both short (12-26 days) and long (7-12 months) survival times, the density of spines was significantly lower (13%) on neostriatal neurones ipsilateral to the 6-hydroxydopamine injection. At longer times the density of spines was lower on neurones both ipsilateral and contralateral to the lesion when compared to neurones taken from short-term animals (23%).

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Authors: Ingham, C. A., Hood, S. H., & Arbuthnott, G. W.
Affiliations: University of Edinburgh (GB)
Corresponding author: Ingham, C.A.
ORCID: Arbuthnott, G.W.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1989-12
Volume: 503
Issue: 2
Pages: 334-338
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(89)91686-7
OpenAlex: W2074379320
Cited by: 219
References: 38
Citations by year: 2025: 4 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 10 · 2018: 3 · 2017: 8 · 2016: 8 · 2015: 14 · 2014: 6 · 2013: 13 · 2012: 7
FWCI: 1.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: dendritic spine density, neostriatum, 6-hydroxydopamine lesion, medial forebrain bundle, striatal neurons, age-related changes, ipsilateral and contralateral effects, dopaminergic neurotoxicity, Golgi impregnation
MeSH terms: Aging, Animals, Corpus Striatum, Dendrites, Hydroxydopamines, Male, Medial Forebrain Bundle, Rats, Inbred Strains, Oxidopamine, Rats

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Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age

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