CoChat
Sign Up
Cited by 57

The DOI matches its Crossref record.

Neurotoxic lesion of the mesencephalic reticular formation and/or the posterior hypothalamus does not alter waking in the cat

Denoyer, Michel, Sallanon, Marcelle, Buda, Colette, Kitahama, Kunio, Jouvet, Michel·1991·Brain Research
DOI 10.1016/0006-8993(91)91633-c
Open this paper in CoChat — free account

Abstract

In order to re-evaluate the role of two putative waking systems, we injected a neural cell body toxin, ibotenic acid (IA) (45 micrograms/microliters), into the mesencephalic reticular formation (MRF) and/or the posterior hypothalamus (PH). On the one hand, when the cell body destruction was only restricted to the MRF, the IA microinjection was followed by a temporary high voltage and slow neocortical electroencephalogram (EEG) during the first 24 postoperative hours and by a subsequent long term increase in waking which lasted 8-12 h. After the first postoperative day, there were no motor disturbances, no aphagia nor adypsia, no alteration of cortical activation and no modification of thermoregulation or of the sleep-waking cycle. On the other hand, the IA microinjection into the PH induced a hypothermia during the first postoperative night and a dramatic transient hypersomnia immediately after the disappearance of the anesthesia (14-24 h after the IA injection). On the third day, all cats recovered control level of paradoxical sleep (PS), slow wave sleep (SWS) and cerebral temperature. They presented normal motor behavior but they were not able to eat by themselves during the first postoperative week. Finally, when the lesions of the MRF and the PH were realized in one single operation, the cats were first motionless in a comatose state for 2-3 days. This state was accompanied by a transitory hypothermia and the suppression of a spontaneous or evoked cortical low voltage fas…

Overview

Integrity signals

Registry

Crossref · 10.1016/0006-8993(91)91633-c

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 59

  1. Adametz, 1959, Rate of recovery of functioning in cats with rostral reticular lesions, J. Neurosurgery, 16, 85, 10.3171/jns.1959.16.1.0085 · DOI
  2. Aston-Jones, 1981, Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle, J. Neurosci., 1, 876, 10.1523/JNEUROSCI.01-08-00876.1981 · DOI · Paper page
  3. Badoer, 1987, Localization of the main noradrenergic neuron groups in the pons and medulla of the rabbit and the importance of cathodal lesions for prolonged survival, J. Neurosci. Methods, 19, 11, 10.1016/0165-0270(87)90017-3 · DOI
  4. Bobillier, 1976, The raphe nuclei of the cat brain stem: a topographical atlas of their efferent projections as revealed by autoradiography, Brain Research, 113, 449, 10.1016/0006-8993(76)90050-0 · DOI
  5. Boulant, 1981, Hypothalamic control of thermoregulation. Neurophysiological basis, Vol. 3, 1
  6. Buzsaki, 1988, Nucleus basalis and thalamic control of neocortical activity in the freely moving rat, J. Neurosci., 8, 4007, 10.1523/JNEUROSCI.08-11-04007.1988 · DOI · Paper page
  7. Celesia, 1966, Acetylcholine released from cerebral cortex in relation to state of activation, Neurology, 16, 1053, 10.1212/WNL.16.11.1053 · DOI
  8. Denoyer, 1989, La destruction des périkaryas de la formation réticulée mésencéphalique et de l'hypothalamus postérieur n'entrîne pas de troubles majeurs de l'éveil chez le chat, C.R. Acad. Sci., 309, 265
  9. French, 1952, Effects of chronic lesions in central cephalic brain stem of monkeys, Arch. Neurol. Psychiatry, 68, 591, 10.1001/archneurpsyc.1952.02320230017002 · DOI
  10. Grossman, 1978, Aphagia and adypsia after preferential destruction of nerve cell bodies in hypothalamus, Science, 202, 537, 10.1126/science.705344 · DOI
  11. Jasper, 1949, Diffuse projection systems: the integrative action of the thalamic reticular system, Electroencephalogr. Clin. Neurophysiol., 1, 405, 10.1016/0013-4694(49)90213-8 · DOI
  12. Jones, 1973, The effect of lesions of catecholamine-containing neurons upon monoamine content of the brain and EEG and behavioral waking in the cat, Brain Research, 58, 157, 10.1016/0006-8993(73)90830-5 · DOI
  13. Jones, 1977, Effects of locus coeruleus lesions upon cerebral monoamine content, sleep-wakefulness states and the response to amphetamine in the cat, Brain Research, 124, 473, 10.1016/0006-8993(77)90948-9 · DOI
  14. Jones, 1988, Neurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-cholinergic cell area in the cat. I. Effects upon the cholinergic innervation of the brain, Brain Research, 451, 13, 10.1016/0006-8993(88)90745-7 · DOI
  15. Jones, 1989, Afferents to the basal forebrain cholinergic cell area from pontomesencephalic-catecholamine, serotonin, and acetylcholine-neurons, Neuroscience, 31, 37, 10.1016/0306-4522(89)90029-8 · DOI
  16. Jouvet, 1972, The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle, Ergebn. Physiol., 64, 166
  17. Kanai, 1965, Mesencephalic reticular activating system and cortical acetylcholine output, Nature, 205, 80, 10.1038/205080b0 · DOI
  18. Kitahama, 1988, Immunohistochemistry of aromaticl-amino acid decar☐ylase in the cat forebrain, J. Comp. Neurol., 270, 337, 10.1002/cne.902700304 · DOI
  19. Kitahama, K., Denoyer, M., Raynaud, B., Borri-Voltattorni, C., Weber, M. and Jouvet, M., Aromaticl-amino acid decar☐ylase-immunohistochemistry in the cat lower brainstem and midbrain, J. Comp. Neurol., in press.
  20. Kitsikis, 1981, Immediate behavioral effects of kainic acid injections into the midbrain reticular core, Behav. Brain Res., 3, 361, 10.1016/0166-4328(81)90005-X · DOI
  21. Kohler, 1979, Intrahippocampal injections of ibotenic acid provide histological evidence for a neurotoxic mechanism different from kainic acid, Neurosci. Lett., 15, 223, 10.1016/0304-3940(79)96117-2 · DOI
  22. Lin, 1986, Neurones immunoréactifsàl'histamine dans l'hypothalamus chez le chat, C.R. Acad. Sci., 303, 371
  23. Lin, 1988, Evidence for histaminergic arousal mechanism in the hypothalamus of cat, Neuropharmacology, 27, 111, 10.1016/0028-3908(88)90159-1 · DOI
  24. Lin, 1989, A critical role of the posterior hypothalamus in the mechanisms of wakefulness determined by microinjection of muscimol in freely moving cats, Brain Research, 479, 225, 10.1016/0006-8993(89)91623-5 · DOI
  25. Lindsley, 1950, Behavioral and EEG changes following chronic brain stem lesions in the cat, Electroencephalogr. Clin. Neurophysiol., 2, 483, 10.1016/0013-4694(50)90086-1 · DOI
  26. Lindvall, 1974, The adrenergic innervation of the rat pothalamus as revealed by the glyoxylic acid fluorescence method, J. Comp. Neurol., 154, 317, 10.1002/cne.901540307 · DOI
  27. Longo, 1966, Behavioral and electroencephalographic effects of atropine and related compounds, Pharmacol. Rev., 18, 965
  28. Maeda, 1973, Les neurones contenant des catécholamines du tegmentum pontique et leurs voies de projection chez le chat, Brain Research, 57, 119, 10.1016/0006-8993(73)90572-6 · DOI
  29. Markowska, 1985, Comparison of electrolytic and ibotenic acid lesions in the lateral hypothalamus, Brain Research, 328, 313, 10.1016/0006-8993(85)91043-1 · DOI
  30. McGinty, 1969, Somnolence, recovery, and hyposomnia following ventromedial diencephalic lesions in the rat, Electroencephalogr. Clin. Neurophysiol., 26, 70, 10.1016/0013-4694(69)90035-2 · DOI
  31. Mesulam, 1983, Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1–Ch6), Neuroscience, 10, 1185, 10.1016/0306-4522(83)90108-2 · DOI
  32. McCormick, 1989, Cholinergic and noradrenergic modulation of thalamocortical processing, Trends Neurosci., 12, 215, 10.1016/0166-2236(89)90125-2 · DOI
  33. Moruzzi, 1949, Brain stem reticular formation and activation of the EEG, Electroencephalogr. Clin. Neurophysiol., 1, 455, 10.1016/0013-4694(49)90219-9 · DOI · Paper page
  34. Moruzzi, 1972, The sleep-waking cycle, Ergebn. Physiol., 64, 1
  35. Nauta, 1946, Hypothalamic regulation of sleep in rats: an experimental study, J. Neurophysiol., 9, 285, 10.1152/jn.1946.9.4.285 · DOI
  36. Nieuwenhuys, 1982, The medial forebrain bundle of the rat. I. General introduction, J. Comp. Neurol., 206, 49, 10.1002/cne.902060106 · DOI
  37. Paré, 1988, Projections of brainstem core cholinergic and non-cholinergic neurons of cat to intralaminar and reticular thalamic nuclei, Neuroscience, 25, 69, 10.1016/0306-4522(88)90007-3 · DOI
  38. Parent, 1981, Organization of ascending serotonin systems in the adult rat brain. A radioautographic study after intraventricular administration of3H-5-hydroxytryptamine, Neuroscience, 6, 115, 10.1016/0306-4522(81)90050-6 · DOI
  39. Parent, 1988, Basal forebrain cholinergic and noncholinergic projections to the thalamus and brainstem in cats and monkeys, J. Comp. Neurol., 277, 281, 10.1002/cne.902770209 · DOI
  40. Ranson, 1939, Somnolence caused by hypothalamic lesion in the monkey, Arch. Neurol. Psychiat., 41, 1, 10.1001/archneurpsyc.1939.02270130011001 · DOI
  41. Rasmussen, 1986, Single unit activity of locus coeruleus neurons in the freely moving cats. I. During naturalistic behaviors and in responses to simple and complex stimuli, Brain Research, 371, 324, 10.1016/0006-8993(86)90370-7 · DOI
  42. Reiner, 1987, Electrophysiological properties of cortically projecting histamine neurons of the rat hypothalamus, Neurosci. Lett., 73, 43, 10.1016/0304-3940(87)90028-0 · DOI
  43. Robinson, 1977, Are the dorsal noradrenergic bundle projections from the locus coeruleus important for neocortical or allocortical activation?, Brain Research, 138, 75, 10.1016/0006-8993(77)90785-5 · DOI
  44. Sakai, 1977, Afferent projections to the cat locus coeruleus as visualized by the horseradish peroxidase technique, Brain Research, 119, 21, 10.1016/0006-8993(77)90089-0 · DOI
  45. Sallanon, 1988, Increase of paradoxical sleep induced by microinjections of ibotenic acid into the ventrolateral part of the posterior hypothalamus in the cat, Arch. Ital. Biol., 126, 87
  46. Sallanon, 1989, Long-lasting insomnia induced by preoptic neuron lesions and its transient reversal by muscimol injection into the posterior hypothalamus, Neuroscience, 32, 1, 10.1016/0306-4522(89)90289-3 · DOI
  47. Shoham, 1982, Subcortical waking and sleep during lateral hypothalamic ‘somnolence’ in rats, Physiol. Behav., 28, 323, 10.1016/0031-9384(82)90082-8 · DOI
  48. Shute, 1967, The ascending cholinergic reticular system: neocortical, olfactory and subcortical projections, Brain, 90, 497, 10.1093/brain/90.3.497 · DOI
  49. Steriade, 1982, Firing rates and patterns of midbrain reticular neurons during steady and transitional states of the sleep-waking cycle, Exp. Brain Res., 46, 37, 10.1007/BF00238096 · DOI
  50. Steriade, 1988, The functional states of the thalamus and the associated neuronal interplay, Physiol. Rev., 68, 649, 10.1152/physrev.1988.68.3.649 · DOI
  51. Steriade, 1988, Projections of cholinergic and non-cholinergic neurons of the brainstem core to relay and associational thalamic nuclei in the cat and macaque monkey, Neuroscience, 25, 47, 10.1016/0306-4522(88)90006-1 · DOI · Paper page
  52. Stuart, 1961, Activation and suppression of shivering during septal and hypothalamic stimulation, Exp. Neurol., 4, 485, 10.1016/0014-4886(61)90048-6 · DOI
  53. Stuart, 1962, Effects of septal and hypothalamic lesions on shivering, Exp. Neurol., 5, 335, 10.1016/0014-4886(62)90042-0 · DOI
  54. Sweet, 1968, The effects of posterior hypothalamic lesions on behavioral and electrographic manifestations of sleep and waking in cats, Arch. Ital. Biol., 106, 283
  55. Vanderwolf, 1981, Reticulocortical activity and behavior: a critique of the arousal theory and a new synthesis, Behav. Brain Sci., 4, 459, 10.1017/S0140525X00009869 · DOI
  56. Vanni-Mercier, 1984, Neurones spécifiques de l'éveil dans l'hypothalamus postérieur du chat, C.R. Acad. Sci., 298, 195
  57. Webster, 1988, Neurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-cholinergic cell area in the cat. II. Effects upon sleep-waking states, Brain Research, 458, 285, 10.1016/0006-8993(88)90471-4 · DOI
  58. Wheatley, 1944, The hypothalamus and affective behavior in cats, Arch. Neurol. Psychiat., 52, 296, 10.1001/archneurpsyc.1944.02290340043004 · DOI
  59. Yoshimoto, 1989, Forebrain afferents to the cat posterior hypothalamus: a double labeling study, Brain Res. Bull., 23, 83, 10.1016/0361-9230(89)90167-6 · DOI

Cited by

Sorted by citations

See all 57

Metadata

Authors
Denoyer, M., Sallanon, M., Buda, C., Kitahama, K., & Jouvet, M.
Venue
Brain Research
Publisher
Elsevier BV
Published
1991-01
Volume
539
Issue
2
Pages
287-303
ISSN
0006-8993
DOI
10.1016/0006-8993(91)91633-c
Cited by
57
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Neurotoxic lesion of the mesencephalic reticular formation and/or the posterior hypothalamus does not alter waking in the cat. https://app.cochat.ai/papers/10.1016/0006-8993(91)91633-c
The paper
Denoyer, M., Sallanon, M., Buda, C., Kitahama, K., & Jouvet, M. (1991). Neurotoxic lesion of the mesencephalic reticular formation and/or the posterior hypothalamus does not alter waking in the cat. Brain Research. https://doi.org/10.1016/0006-8993(91)91633-c