The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The formation of peroxynitrite in vivo from nitric oxide and superoxide
Abstract
Peroxynitrite is predicted to be formed in vivo from the reaction of nitric oxide and superoxide. Nitric oxide at concentrations as low as 3 nM is expected to compete efficiently for superoxide near the surface of endothelial cells, based on competition kinetics.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition, peroxynitrite is capable of nitrating tyrosine or tryptophan residues, or oxidising methionine residues [123,124,125,126,127,128].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [123]
Citations
Cites
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,400
Radí, R., Beckman, J. S., Bush, K. M., & Freeman, B. Α. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90224-7 · Cited by 2,201
The reaction of NO with superoxide
Huie, R. E., & Padmaja, S. (1993) · Free Radical Research Communications · doi:10.3109/10715769309145868 · Cited by 2,121
The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511
Self-citationPeroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D. L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90431-u · Cited by 1,499
Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
Koppenol, W. H., Moreno, J. J., Pryor, W. A., Ischiropoulos, H., & Beckman, J. S. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00030a017 · Cited by 1,338
Self-citationExtensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry
Beckman, J. S., Ye, Y. Z., Anderson, P. G., Chen, J., Accavitti, M. A., Tarpey, M. M., & White, C. R. (1994) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1994.375.2.81 · Cited by 1,122
Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor
Maliñski, T., & Taha, Z. (1992) · Nature · doi:10.1038/358676a0 · Cited by 1,071
Ignarro, L. J. (1989) · Circulation Research · doi:10.1161/01.res.65.1.1 · Cited by 964
Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.
Wink, D. A., Hanbauer, I., Krishna, M. C., DeGraff, W., Gamson, J., & Mitchell, J. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.9813 · Cited by 766
Endogenous nitric oxide: physiology, pathology and clinical relevance
Moncada, S., & Higgs, E. A. (1991) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1991.tb01383.x · Cited by 760
Biological Roles of Nitric Oxide
Snyder, S. H., & Bredt, D. S. (1992) · Scientific American · doi:10.1038/scientificamerican0592-68 · Cited by 720
Pathological implications of nitric oxide, superoxide and peroxynitrite formation
Beckman, J. S., & Crow, J. P. (1993) · Biochemical Society Transactions · doi:10.1042/bst0210330 · Cited by 674
Malinski, T., Bailey, F., Zhang, Z. G., & Chopp, M. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.48 · Cited by 625
Inhibition of low‐density lipoprotein oxidation by nitric oxide Potential role in atherogenesis
Hogg, N., Kalyanaraman, B., Joseph, J., Struck, A. T., & Parthasarathy, S. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81706-6 · Cited by 400
Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite
van der Vliet, A., O’neill, C. A., Halliwell, B. B., Cross, C. E., & Kaur, H. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80391-9 · Cited by 381
Superoxide dismutase: The first twenty years (1968–1988)
McCord, J. M., & Fridovich, I. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90109-8 · Cited by 381
Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle
Rubanyi, G. M., & Vanhoutte, P. M. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.5.h815 · Cited by 376
Rubanyi, G. M., Ho, E. H., Cantor, E. H., Lumma, W. C., & Botelho, L. H. P. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)92093-y · Cited by 360
Traylor, T. G., & Sharma, V. S. (1992) · Biochemistry · doi:10.1021/bi00126a001 · Cited by 354
Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major
Assreuy, J., Cunha, F. Q., Epperlein, M. M., Noronha-Dutra, A. A., O’Donnell, C. A., Liew, F. Y., & Moncada, S. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240328 · Cited by 270
Reaction of No With O2−. Implications for the Action of Endothelium-Derived Relaxing Factor (EDRF)
Sarán, M., Michel, C., Bors, W., & Czapski, G. (1990) · Free Radical Research Communications · doi:10.3109/10715769009149890 · Cited by 269
Inactivation of .alpha.1-proteinase inhibitor by peroxynitrite
Moreno, J. J., & Pryor, W. A. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00027a017 · Cited by 250
Self-citationFree Radical Chemistry of Nitric Oxide
Freeman, B. Α. (1994) · CHEST Journal · doi:10.1378/chest.105.3_supplement.79s · Cited by 167
Wang, J. F., Komarov, P. G., Sies, H., & de GROOT, H. (1991) · Biochemical Journal · doi:10.1042/bj2790311 · Cited by 100
Unraveling the biological significance of nitric oxide.
Marletta, M. A., Tayeh, M. A., & Hevel, J. M. (1990) · PubMed · Cited by 100
Sarán, M., & Bors, W. (1994) · Chemico-Biological Interactions · doi:10.1016/0009-2797(94)90109-0 · Cited by 85
Nitric oxide donor GEA 3162 inhibits endothelial cell‐mediated oxidation of low density lipoprotein
Malo‐Ranta, U., Ylä‐Herttuala, S., Metsä‐Ketelä, T., Jaakkola, O., Moilanen, E., Vuorinen, P., & Nikkari, T. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80269-6 · Cited by 79
Endothelium-derived relaxing factor is identified as nitric oxide
Moncada, S., Herman, A. G., & Vanhoutte, P. M. (1987) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(87)90090-3 · Cited by 78
Goldschmidt, J., & Tallarida, R. J. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24682-1 · Cited by 63
Inhibition of nitric oxide synthase by a superoxide generating system.
Rengasamy, A., & Johns, R. A. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39378-x · Cited by 41
Cited by
Sorted by citations
The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511
Self-citationA Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
Perron, N. R., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9043-x · Cited by 1,370
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
Nagaraj, S., Gupta, K., Писарев, В. М., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J. P., & Gabrilovich, D. I. (2007) · Nature Medicine · doi:10.1038/nm1609 · Cited by 1,176
Melatonin as a natural ally against oxidative stress: a physicochemical examination
Galano, A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00916.x · Cited by 1,167
Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases
Collin, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102407 · Cited by 852
Metadata
- Authors
- Squadrito, G. L., & Pryor, W. A.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Pryor, William A.
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 1995-05
- Volume
- 96
- Issue
- 2
- Pages
- 203-206
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W2076052581
- Cited by
- 200
- References
- 35
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 1 · 2014: 6 · 2013: 7 · 2012: 3
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- peroxynitrite, nitric oxide, superoxide, nitrosative stress, endothelial cells, competition kinetics, reactive oxygen species, in vivo formation
- MeSH terms
- Endothelium, Vascular, Kinetics, Nitrates, Nitric Oxide, Superoxides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review