Cited by 200Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

The formation of peroxynitrite in vivo from nitric oxide and superoxide

Squadrito, Giuseppe L., Pryor, William A.·1995·Chemico-Biological Interactions

DOI 10.1016/0009-2797(94)03591-u

Open this paper in CoChat — free account

Abstract

Peroxynitrite is predicted to be formed in vivo from the reaction of nitric oxide and superoxide. Nitric oxide at concentrations as low as 3 nM is expected to compete efficiently for superoxide near the surface of endothelial cells, based on competition kinetics.

Integrity signals

Registry

Crossref · 10.1016/0009-2797(94)03591-u

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Superoxide Dismutase
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,400
Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide
Radí, R., Beckman, J. S., Bush, K. M., & Freeman, B. Α. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90224-7 · Cited by 2,201
The reaction of NO with superoxide
Huie, R. E., & Padmaja, S. (1993) · Free Radical Research Communications · doi:10.3109/10715769309145868 · Cited by 2,121
The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511
Self-citation
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D. L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90431-u · Cited by 1,499
Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives
Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
Koppenol, W. H., Moreno, J. J., Pryor, W. A., Ischiropoulos, H., & Beckman, J. S. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00030a017 · Cited by 1,338
Self-citation

Show all 35 references

Sorted by citations

The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511
Self-citation
A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
Perron, N. R., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9043-x · Cited by 1,370
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
Nagaraj, S., Gupta, K., Писарев, В. М., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J. P., & Gabrilovich, D. I. (2007) · Nature Medicine · doi:10.1038/nm1609 · Cited by 1,176
Melatonin as a natural ally against oxidative stress: a physicochemical examination
Galano, A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00916.x · Cited by 1,167
Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases
Collin, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102407 · Cited by 852
Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide
Squadrito, G. L., & Pryor, W. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00095-1 · Cited by 800
Self-citation
High Glucose Increases Nitric Oxide Synthase Expression and Superoxide Anion Generation in Human Aortic Endothelial Cells
Cosentino, F., Hishikawa, K., Katušić, Z. S., & Lüscher, T. F. (1997) · Circulation · doi:10.1161/01.cir.96.1.25 · Cited by 762
Formation, Prevention, and Repair of DNA Damage by Iron/Hydrogen Peroxide
Henle, E. S., & Linn, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19095 · Cited by 593
Role of oxidants in microbial pathophysiology
Miller, R. A., & Britigan, B. E. (1997) · Clinical Microbiology Reviews · doi:10.1128/cmr.10.1.1 · Cited by 576
Hypertension and aging
Buford, T. W. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.007 · Cited by 622
Measurement of Nitric Oxide and Peroxynitrite Generation in the Postischemic Heart
Wang, P., & Zweier, J. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.29223 · Cited by 542
Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1–dependent mechanism that is up-regulated by interleukin-13
Highfill, S. L., Rodrı́guez, P. C., Zhou, Q., Goetz, C. A., Koehn, B. H., Veenstra, R. G., Taylor, P. A., Panoskaltsis‐Mortari, A., Serody, J. S., Munn, D. H., et al. (2010) · Blood · doi:10.1182/blood-2010-06-287839 · Cited by 465
Formation of Nitrating and Chlorinating Species by Reaction of Nitrite with Hypochlorous Acid
Eiserich, J. P., Cross, C. E., Jones, A. D., Halliwell, B., & van der Vliet, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.32.19199 · Cited by 447
A Newly Identified Role for Superoxide in Inflammatory Pain
Wang, Z., Porreca, F., Cuzzocrea, S., Galen, K. P., Lightfoot, R. T., Masini, E., Muscoli, C., Mollace, V., Ndengele, M. M., Ischiropoulos, H., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.064154 · Cited by 387
Manganese Superoxide Dismutase: Guardian of the Powerhouse
Holley, A. K., Bakthavatchalu, V., Velez-Roman, J. M., & St. Clair, D. K. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12107114 · Cited by 358
Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity
Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031841 · Cited by 342
Physiological and Pathophysiological Roles of Nitric Oxide in the Central Nervous System
Szabó, C. (1996) · Brain Research Bulletin · doi:10.1016/0361-9230(96)00159-1 · Cited by 295
Raman spectroscopy in cell biology and microbiology
Pezzotti, G. (2021) · Journal of Raman Spectroscopy · doi:10.1002/jrs.6204 · Cited by 296
On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies
Muscoli, C., Cuzzocrea, S., Riley, D. P., Zweier, J. L., Thiemermann, C., Wang, Z., & Salvemini, D. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705430 · Cited by 271
Sod mimetics are coming of age
Salvemini, D., Riley, D. P., & Cuzzocrea, S. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd796 · Cited by 265
DNA strand breakage and activation of poly-ADP ribosyltransferase: A cytotoxic pathway triggered by peroxynitrite
Szabó, C. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00170-0 · Cited by 252
Oxidative Stress in a Rat Model of Obesity-Induced Hypertension
Dobrian, A. D., Davies, M. J., Schriver, S. D., Lauterio, T. J., & Prewitt, R. L. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.554 · Cited by 246
Antioxidative properties of phenolic compounds and their effect on oxidative stress induced by severe physical exercise
Kruk, J., Aboul-Enein, B. H., Duchnik, E., & Marchlewicz, M. (2022) · The Journal of Physiological Sciences · doi:10.1186/s12576-022-00845-1 · Cited by 271
Global Ischemia Activates Nuclear Factor-κB in Forebrain Neurons of Rats
Clemens, J. A., Stephenson, D. T., Smalstig, E. B., Dixon, E. P., & Little, S. P. (1997) · Stroke · doi:10.1161/01.str.28.5.1073 · Cited by 215
Nitric oxide in renal health and disease
Kone, B. C. (1997) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(97)90275-4 · Cited by 211
Oxidative stress: a theoretical model or a biological reality?
Sorg, O. (2004) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2004.05.007 · Cited by 205
Observation of the Generation of ONOO– in Mitochondria under Various Stimuli with a Sensitive Fluorescence Probe
Li, H., Li, X., Wu, X., Shi, W. S., & Ma, H. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00503 · Cited by 181
Response of Glial Cells to Ischemia: Roles of Reactive Oxygen Species and Glutathione
Juurlink, B. H. J. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00005-x · Cited by 181
Peroxynitrite
Murphy, M. P., Packer, M. A., Scarlett, J. L., & Martin, S. W. (1998) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)00418-7 · Cited by 180
Peroxynitrite: A two-faced metabolite of nitric oxide
Muijsers, R. B. R., Folkerts, G., Henricks, P. A. J., Sadeghi-Hashjin, G., & Nijkamp, F. P. (1997) · Life Sciences · doi:10.1016/s0024-3205(96)00651-0 · Cited by 176
Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation
Salvemini, D., Doyle, T., & Cuzzocrea, S. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340965 · Cited by 170
Ways to Enhance Lymphocyte Trafficking into Tumors and Fitness of Tumor Infiltrating Lymphocytes
Bellone, M., & Calcinotto, A. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00231 · Cited by 167
Mechanisms of H2O2-induced oxidative stress in endothelial cells
Coyle, C. H., Martínez, L. J., Coleman, M. C., Spitz, D. R., Weintraub, N. L., & Kader, K. N. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.02.017 · Cited by 161
Apocynin inhibits peroxynitrite formation by murine macrophages
Muijsers, R. B. R., van den Worm, E., Folkerts, G., Beukelman, C. J., Koster, A. S., Postma, D. S., & Nijkamp, F. P. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703401 · Cited by 160
The Peroxynitrite Scavenger Uric Acid Prevents Inflammatory Cell Invasion into the Central Nervous System in Experimental Allergic Encephalomyelitis through Maintenance of Blood-Central Nervous System Barrier Integrity
Kean, R. B., Spitsin, S. V., Mikheeva, T., Scott, G. S., & Hooper, D. C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6511 · Cited by 157
Oxidation-Triggered Release of Fluorescent Molecules or Drugs from Mesoporous Si Microparticles
Wu, E. C., Park, J., Park, J., Segal, E., Cunin, F., & Sailor, M. J. (2008) · ACS Nano · doi:10.1021/nn800592q · Cited by 158
Redox Regulation of Nuclear Factor Kappa B: Therapeutic Potential for Attenuating Inflammatory Responses
Christman, J. W., Blackwell, T. S., & Juurlink, B. H. J. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00252.x · Cited by 148
Regulation of the Brain’s Vascular Responses to Oxygen
It, D., Oury, T. D., Crapo, J. D., & Piantadosi, C. A. (2002) · Circulation Research · doi:10.1161/01.res.0000043500.03647.81 · Cited by 140
Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403
Salvemini, D., Mazzon, E., Dugo, L., Riley, D. P., Serraino, I., Caputi, A. P., & Cuzzocrea, S. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703841 · Cited by 133
Global cerebral ischemia activates nuclear factor-κB prior to evidence of DNA fragmentation
Clemens, J. A., Stephenson, D. T., Dixon, E. P., Smalstig, E. B., Mincy, R. E., Rash, K. S., & Little, S. P. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00092-2 · Cited by 122
Antioxidant and Probiotic Properties of Lactobacilli and Bifidobacteria of Human Origins
Kim, H., Kim, J.-S., Kim, Y., Jeong, Y., Kim, J.-E., Paek, N.-S., & Kang, C.-H. (2020) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-020-0147-x · Cited by 121
Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity
Dobrian, A. D., Schriver, S. D., Lynch, T. J., & Prewitt, R. L. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00388.2002 · Cited by 121
Expression of peroxisome proliferator-activated receptor-γ in macrophage suppresses experimentally induced colitis
Shah, Y. M., Morimura, K., & Gonzalez, F. J. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00381.2006 · Cited by 120
Nitric oxide and vascular responses in Type I diabetes
Chan, N. N., Vallance, P. J., & Colhoun, H. M. (2000) · Diabetologia · doi:10.1007/s001250050022 · Cited by 115
Medicinal uses of mushrooms in Nigeria: towards full and sustainable exploitation
Oyetayo, O. V. (2011) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.4314/ajtcam.v8i3.65289 · Cited by 111
Superoxide Dismutase Mimetics
Salvemini, D., Muscoli, C., Riley, D. P., & Cuzzocrea, S. (2002) · Pulmonary Pharmacology & Therapeutics · doi:10.1006/pupt.2002.0374 · Cited by 105
In Vivo Aspects of Nitric Oxide (NO) Chemistry: Does Peroxynitrite (-OONO) Play a Major Role in Cytotoxicity?
Fukuto, J. M., & Ignarro, L. J. (1997) · Accounts of Chemical Research · doi:10.1021/ar960010y · Cited by 101
Peroxynitrite Reduces Myocardial Infarct Size and Preserves Coronary Endothelium After Ischemia and Reperfusion in Cats
Nossuli, T. O., Hayward, R., Scalia, R. G., & Lefer, A. M. (1997) · Circulation · doi:10.1161/01.cir.96.7.2317 · Cited by 99
Role of Angiotensin II and Free Radicals in Blood Pressure Regulation in a Rat Model of Renal Hypertension
Dobrian, A. D., Schriver, S. D., & Prewitt, R. L. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.361 · Cited by 99
Effects of diabetes, insulin and antioxidants on NO synthase abundance and NO interaction with reactive oxygen species
Koo, J.-R., & Vaziri, N. D. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00728.x · Cited by 97
Plasma Extracellular Superoxide Dismutase Levels in an Australian Population With Coronary Artery Disease
Wang, X. L., Adachi, T., Sim, A. S., & Wilcken, D. E. L. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.12.1915 · Cited by 96
Contributions of Endothelial and Neuronal Nitric Oxide Synthases to Cerebrovascular Responses to Hyperoxia
Atochin, D. N., It, D., Astern, J., Boso, A. E., Piantadosi, C. A., & Huang, P. L. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000089601.87125.e4 · Cited by 94
Inhibition of Astrocyte Glutamate Uptake by Reactive Oxygen Species: Role of Antioxidant Enzymes
Sorg, O., Horn, T. F. W., Yu, N., Gruol, D. L., & Bloom, F. E. (1997) · Molecular Medicine · doi:10.1007/bf03401690 · Cited by 92
Thrombospondin-1 Activation of Signal-Regulatory Protein-α Stimulates Reactive Oxygen Species Production and Promotes Renal Ischemia Reperfusion Injury
Yao, M., Rogers, N. M., Csányi, G., Rodriguez, A. I., Ross, M. A., Croix, C. M. S., Knupp, H. E., Novelli, E. M., Thomson, A. W., Pagano, P. J., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013040433 · Cited by 89
Nitric oxide production is enhanced in rat brain before oxygen-induced convulsions
It, D., Boso, A. E., Whorton, A. R., & Piantadosi, C. A. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03057-8 · Cited by 86
Hyperbaric Oxygen Reduces Cerebral Blood Flow by Inactivating Nitric Oxide
It, D., Boso, A. E., Bennett, P. B., Whorton, A. R., & Piantadosi, C. A. (2000) · Nitric Oxide · doi:10.1006/niox.2000.0313 · Cited by 85
A Two-Photon Fluorescent Probe for Imaging Endogenous ONOO– near NMDA Receptors in Neuronal Cells and Hippocampal Tissues
Lee, D., Lim, C. S., Ko, G., Kim, D., Cho, M. K., Nam, S., Kim, H. M., & Yoon, J. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01960 · Cited by 80
Nitric Oxide, Iron and Neurodegeneration
Liu, C., Liang, M. C., & Soong, T. W. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00114 · Cited by 80
The Central Nervous System Inflammatory Response to Neurotropic Virus Infection Is Peroxynitrite Dependent
Hooper, D. C., Kean, R. B., Scott, G. S., Spitsin, S. V., Mikheeva, T., Morimoto, K., Bette, M., Röhrenbeck, A. M., Dietzschold, B., & Weihe, E. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3470 · Cited by 79
Relationship Between Homocysteine and Superoxide Dismutase in Homocystinuria
Wilcken, D. E. L., Wang, X. L., Adachi, T., Hara, H., Duarte, N., Green, K., & Wilcken, B. M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.5.1199 · Cited by 74
Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: A histopathological study
Martinović, J., Todorović, N., Tomanović, N., Bošković, M., Djordjević, S., Pašti, T. D. L., Bernardi, R. E., Djurdjevic, A., & Filipović, D. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.04.010 · Cited by 77
Shear-Induced Increase in Hydraulic Conductivity in Endothelial Cells Is Mediated by a Nitric Oxide–Dependent Mechanism
Chang, Y. S., Yaccino, J. A. M., Lakshminarayanan, S., Frangos, J. A., & Tarbell, J. M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.1.35 · Cited by 73
Superoxide dismutase activity of corrole metal complexes
Eckshtain‐Levi, M., Zilbermann, I., Mahammed, A., Saltsman, I., Okun, Z., Maimon, E., Cohen, H., Meyerstein, D., & Gross, Z. (2009) · Dalton Transactions · doi:10.1039/b911278b · Cited by 71
Inorganic sulfur–nitrogen compounds: from gunpowder chemistry to the forefront of biological signaling
Cortese-Krott, M. M., Butler, A. R., Woollins, J. D., & Feelisch, M. (2016) · Dalton Transactions · doi:10.1039/c5dt05034k · Cited by 70
Effect of exogenous nitric oxide on antioxidative system and S-nitrosylation in leaves of Boehmeria nivea (L.) Gaud under cadmium stress
Wang, D., Liu, Y., Tan, X., Liu, H., Zeng, G., Hu, X., Jian, H., & Gu, Y. (2014) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3581-5 · Cited by 69
Role of nitric oxide in the physiopathology of pain
Anbar, M., & Gratt, B. M. (1997) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(97)00178-4 · Cited by 69
The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance
Vajapey, R. S., Rini, D. A., Walston, J. D., & Abadir, P. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00439 · Cited by 70
Colon Epithelial Cell Death in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis Is Associated with Increased Inducible Nitric-Oxide Synthase Expression and Peroxynitrite Production
Yue, G., Lai, P.-S., Yin, K., Sun, F. F., Nagele, R. G., Liu, X., Linask, K. K., Wang, C., Lin, K.-T., & Wong, P. Y.-K. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29615-4 · Cited by 66
Oxidation and Nitrosation in the Nitrogen Monoxide/Superoxide System
Daiber, A., Frein, D., Namgaladze, D., & Ullrich, V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111988200 · Cited by 64
Flavonoids and tyrosine nitration: structure–activity relationship correlation with enthalpy of formation
Sadeghipour, M., Terreux, R., & Phipps, J. (2004) · Toxicology in Vitro · doi:10.1016/j.tiv.2004.06.009 · Cited by 60
Depletion of the cellular antioxidant system contributes to tenofovir disoproxil fumarate - induced mitochondrial damage and increased oxido-nitrosative stress in the kidney
Abraham, P., Ramamoorthy, H., & Isaac, B. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-61 · Cited by 59
A ratiometric fluorescent probe for the detection of peroxynitrite with simple synthesis and large emission shift and its application in cells image
Zhou, D.-Y., Ouyang, J., Li, Y., Jiang, W., Tian, Y., Yi, Z., & Li, C. (2018) · Dyes and Pigments · doi:10.1016/j.dyepig.2018.09.059 · Cited by 59
Two-photon ESIPT-based fluorescent probe using 4-hydroxyisoindoline-1,3-dione for the detection of peroxynitrite
Wu, L., Tian, X., Lee, D. J., Yoon, J., Lim, C. S., Kim, H. M., & James, T. D. (2021) · Chemical Communications · doi:10.1039/d1cc03160k · Cited by 57
A mitochondria-targeting highly specific fluorescent probe for fast sensing of endogenous peroxynitrite in living cells
Shu, W., Wu, Y., Zang, S., Su, S., Kang, H., Jing, J., & Zhang, X. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.127284 · Cited by 58
Role of mitochondrial complexes I and II, reactive oxygen species and arachidonic acid metabolism in deoxycholate-induced apoptosis
Washo-Stultz, D., Crowley-Weber, C. L., Dvorakova, K., Bernstein, C., Bernstein, H., Kunke, K., Waltmire, C. N., Garewal, H. S., & Payne, C. M. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00786-8 · Cited by 58
Nitric oxide and hypercholesterolemia: a matter of oxidation and reduction?
Wever, R. M. F., Stroes, E. S. G., & Rabelink, T. J. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00304-3 · Cited by 59
Nitrosative stress in cancer therapy
David, G. H. (2007) · Frontiers in bioscience · doi:10.2741/2322 · Cited by 57
Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice
Paola, R. D., Mazzon, E., Muià, C., Genovese, T., Menegazzi, M., Zaffini, R., Suzuki, H., & Cuzzocrea, S. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-66 · Cited by 57
An efficient TP-FRET-based lysosome-targetable fluorescent probe for imaging peroxynitrite with two well-resolved emission channels in living cells, tissues and zebrafish
Sun, S.-G., Ding, H., Yuan, G., & Zhou, L. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.11.065 · Cited by 57
Mechanisms Underlying Resistance of Pancreatic Islets from ALR/Lt Mice to Cytokine-Induced Destruction
Mathews, C. E., Suarez‐Pinzon, W. L., Baust, J., Strynadka, K., Leiter, E. H., & Rabinovitch, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.2.1248 · Cited by 55
Differential Hydroxylation of Salicylate in Core and Penumbra Regions During Focal Reversible Cerebral Ischemia
Solenski, N. J., Kwan, A., Yanamoto, H., Bennett, J. P., Kassell, N. F., & Lee, K. S. (1997) · Stroke · doi:10.1161/01.str.28.12.2545 · Cited by 55
A deep red ratiometric fluorescent probe for accurate detection of peroxynitrite in mitochondria
Han, R., Shu, W., Kang, H., Duan, Q., Zhang, X., Liang, C., Gao, M., Xu, L., Jing, J., & Zhang, X. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.339652 · Cited by 53
Effect of asiatic acid on the Ang II-AT1R-NADPH oxidase-NF-κB pathway in renovascular hypertensive rats
Maneesai, P., Bunbupha, S., Kukongviriyapan, U., Senggunprai, L., Kukongviriyapan, V., Prachaney, P., & Pakdeechote, P. (2017) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-017-1408-x · Cited by 52
Management of oxidative stress in the CNS: The many roles of glutathione
Juurlink, B. H. J. (1999) · Neurotoxicity Research · doi:10.1007/bf03033276 · Cited by 52
DAF-FM (4-Amino-5-methylamino-2′,7′-difluorofluorescein) Diacetate Detects Impairment of Agonist-Stimulated Nitric Oxide Synthesis by Elevated Glucose in Human Vascular Endothelial Cells: Reversal by Vitamin C and l-Sepiapterin
Sheng, J., Wang, D., & Braun, A. P. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087932 · Cited by 50
Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component
Juurlink, B. H. J. (2001) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y00-120 · Cited by 51
A specific AIE and ESIPT fluorescent probe for peroxynitrite detection and imaging in living cells
Shen, Y., Li, M., Yang, M., Zhang, Y., Li, H., & Zhang, X. (2019) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2019.117230 · Cited by 50
Reactive Nitrogen Species in Colon Carcinogenesis
Payne, C. M., Bernstein, C., Bernstein, H., Gerner, E. W., & Garewal, H. S. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.4-449 · Cited by 48
Protein nitration: A connecting bridge between nitric oxide (NO) and plant stress
Corpas, F. J., González‐Gordo, S., & Palma, J. M. (2021) · Plant Stress · doi:10.1016/j.stress.2021.100026 · Cited by 47
Superoxide, no, peroxynitrite and PARP in circulatory shock and inflammation
Esposito, E. (2009) · Frontiers in bioscience · doi:10.2741/3244 · Cited by 44
NADPH oxidases as electrochemical generators to produce ion fluxes and turgor in fungi, plants and humans
Segal, A. W. (2016) · Open Biology · doi:10.1098/rsob.160028 · Cited by 41
In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids fromGingko biloba yellow leaves
Hyun, S. K., Jung, H. A., Chung, H. Y., & Choi, J. S. (2006) · Archives of Pharmacal Research · doi:10.1007/bf02969294 · Cited by 44
Mitochondrial superoxide mediates labile iron level: evidence from Mn-SOD-transgenic mice and heterozygous knockout mice and isolated rat liver mitochondria
Ibrahim, W. H., Habib, H. M., Kamal, H., Clair, D. K. S., & Chow, C. K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.026 · Cited by 44
In vitro antibacterial activity of oxide and non-oxide bioceramics for arthroplastic devices: I. In situ time-lapse Raman spectroscopy
Pezzotti, G., Bock, R. M., McEntire, B. J., Adachi, T., Marin, E., Boschetto, F., Zhu, W., Mazda, O., & Bal, B. S. (2018) · The Analyst · doi:10.1039/c8an00233a · Cited by 43
Differing Effects of Copper, Zinc Superoxide Dismutase Overexpression on Neurotoxicity Elicited by Nitric Oxide, Reactive Oxygen Species, and Excitotoxins
Ying, W., Anderson, C. M., Chen, Y., Stein-Behrens, B., Fahlman, C. S., Copin, J., Chan, P. H., & Swanson, R. A. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200002000-00018 · Cited by 43
Melatonin limits lung injury in bleomycin treated mice
Genovese, T., Paola, R. D., Mazzon, E., Muià, C., Caputi, A. P., & Cuzzocrea, S. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00229.x · Cited by 42
Role of Nitric Oxide and Peroxynitrite in Bile Salt-Induced Apoptosis: Relevance to Colon Carcinogenesis
Washo-Stultz, D., Hoglen, N. C., Bernstein, H., Bernstein, C., & Payne, C. M. (1999) · Nutrition and Cancer · doi:10.1207/s15327914nc352_13 · Cited by 42
Garcinia mangostana pericarp extract protects against oxidative stress and cardiovascular remodeling via suppression of p47 phox and iNOS in nitric oxide deficient rats
Boonprom, P., Boonla, O., Chayaburakul, K., Welbat, J. U., Pannangpetch, P., Kukongviriyapan, U., Kukongviriyapan, V., Pakdeechote, P., & Prachaney, P. (2017) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2017.03.007 · Cited by 41
A spontaneous solid-state NO donor to fight antibiotic resistant bacteria
Pezzotti, G. (2018) · Materials Today Chemistry · doi:10.1016/j.mtchem.2018.05.004 · Cited by 41
Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis
Bezerra, M. M., Brain, S. D., Girão‐Carmona, V. C. C., Greenacre, S., Keeble, J. E., & Rocha, F. A. C. (2006) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-006-0123-9 · Cited by 42

Authors: Squadrito, G. L., & Pryor, W. A.
Affiliations: Louisiana State University (US)
Corresponding author: Pryor, William A.
Venue: Chemico-Biological Interactions
Publisher: Elsevier BV
Published: 1995-05
Volume: 96
Issue: 2
Pages: 203-206
ISSN: 0009-2797 (ISSN-L)
DOI: 10.1016/0009-2797(94)03591-u
OpenAlex: W2076052581
Cited by: 200
References: 35
Citations by year: 2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 1 · 2014: 6 · 2013: 7 · 2012: 3
FWCI: 2.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Chemico-Biological Interactions (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: peroxynitrite, nitric oxide, superoxide, nitrosative stress, endothelial cells, competition kinetics, reactive oxygen species, in vivo formation
MeSH terms: Endothelium, Vascular, Kinetics, Nitrates, Nitric Oxide, Superoxides

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The formation of peroxynitrite in vivo from nitric oxide and superoxide

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks