Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells.
Abstract
The effects of interleukin-6 on prostaglandin production by cells from two key sources on intrauterine prostaglandin, i.e. amnion and decidua, have been evaluated. Interleukin-6 induced a concentration-related increase in prostaglandin production by amnion and decidual cells. The concentrations of interleukin-6 required for this stimulatory action are within the range measured in amniotic fluid of women with intrauterine infections and preterm labor. Hence, interleukin-6 may contribute to the mechanism of preterm labor under these conditions.
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IL-6 is remarkably noninflammatory in tissues.
“One of the conundrums is that IL-6 is remarkably noninflammatory in tissues, and although there are some reports that IL-6 induces PGs in non-CNS cells, this seems to be uncommon and to occur at quite high concentrations (57) despite the presence of a nuclear factor IL-6 site upstream of the COX-2 gene (58).”
From Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice (2003) · cites this paper as [57]
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- Authors
- Mitchell, M. D., Dudley, D. J., Edwin, S. S., & Schiller, S. L.
- Affiliations
- University of Utah (US)
- Corresponding author
- Mitchell, Murray D.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1991-01
- Volume
- 192
- Issue
- 1
- Pages
- 189-191
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2073499642
- Cited by
- 228
- References
- 7
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 1 · 2013: 2 · 2012: 11
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Utah
- National Institutes of Health (7r01hd020779-04, 5r01hd020747-08)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-20747, HD 20779)
- Topics
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- interleukin-6, prostaglandin synthesis, amniotic membrane, decidua, preterm labor, intrauterine infection, amniotic fluid, prostaglandin E2
- MeSH terms
- Amnion, Decidua, Female, Humans, Placenta, Pregnancy, Prostaglandins, Dinoprostone, Interleukin-6, In Vitro Techniques
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