The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury
Open accessAbstract
The expression of immune-associated (MHC class II) antigen was studied immunohistochemically over several months in the rat facial nucleus after nerve transection and after intraneural injection of toxic ricin. Cells expressing Ia antigen were of a perivascular type and parenchymal ramified microglia. In the first few weeks after nerve lesions we observed a gradual increase in the number of Ia-immunoreactive cells starting with an initial appearance of Ia-positive perivascular cells which were succeeded by increasing numbers of Ia-positive ramified microglia. In long-term animals Ia expression was almost exclusively found in microglia. We propose (a) the existence of a population of immunocompetent perivascular cells normally present in adult rat brain that can be stimulated to express Ia antigen, and (b) the existence of a subpopulation of ramified microglia that arises through transformation of Ia-positive perivascular cells in the adult under pathological conditions.
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Cites
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Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
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Cited by
Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096
Self-citationMicroglial Activation and Chronic Neurodegeneration
Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047
“A possible mechanism for this could be replenishment from perivascular cells, which are bone marrow-derived and have been shown to enter the CNS and differentiate into microglia.(12,13) The mechanisms through which circulating cells are recruited to the CNS, and whether they enter the CNS under normal, resting conditi…”
BackgroundDystrophic microglia in the aging human brain
Streit, W. J., Sammons, N. W., Kuhns, A. J., & Sparks, D. L. (2004) · Glia · doi:10.1002/glia.10319 · Cited by 705
Self-citationMicroglia in degenerative neurological disease
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Microglia during development and aging
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Microglial senescence: does the brain's immune system have an expiration date?
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Self-citationRole of microglia in CNS inflammation
Graeber, M. B., Li, W., & Rodriguez, M. L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.08.033 · Cited by 392
Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia
Deleo, J. A., Tanga, F. Y., & Tawfik, V. L. (2004) · The Neuroscientist · doi:10.1177/1073858403259950 · Cited by 371
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Self-citationMicroglia actions in Alzheimer's disease
Prokop, S., Miller, K. R., & Heppner, F. L. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1182-x · Cited by 291
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“For example, very few parenchymal, ramified microglia-like cells are found to express the donor MHC class I haplotype (Matsumoto and Fujiwara, 1987): rather, positive cells are localized preferentially in the white matter (Mattiace et al., 1990; Streit et al., 1989).”
Parkinson’s disease as a result of aging
Rodriguez, M., Rodriguez‐Sabate, C., Morales, I., Sanchez, A., & Sabate, M. (2015) · Aging Cell · doi:10.1111/acel.12312 · Cited by 214
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Self-citationWilliams, K., Alvarez, X., & Lackner, A. A. (2001) · Glia · doi:10.1002/glia.1105 · Cited by 190
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Microglial Activation in Alzheimer Disease: Association with APOE Genotype
Egensperger, R., Kösel, S., von Eitzen, U., & Graeber, M. B. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00166.x · Cited by 164
Self-citationMicroglial degeneration in the aging brain - bad news for neurons?
Streit, W. (2008) · Frontiers in Bioscience · doi:10.2741/2937 · Cited by 150
Self-citationTurnover of Rat Brain Perivascular Cells
Bechmann, I., Kwidzinski, E., Kovac, A. D., Simbürger, E., Horvath, T., Gimsa, U., Dirnagl, U., Priller, J., & Nitsch, R. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7618 · Cited by 134
The effects of aging, injury and disease on microglial function: a case for cellular senescence
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Self-citationDifferential Expression of MHC Class II Antigen in the Contused Rat Spinal Cord
POPOVICH, P. G., STREIT, W. J., & STOKES, B. T. (1993) · Journal of Neurotrauma · doi:10.1089/neu.1993.10.37 · Cited by 42
Self-citationAre Microglial Cells the Regulators of Lymphocyte Responses in the CNS?
Almolda, B., González, B., & Castellano, B. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00440 · Cited by 34
Metadata
- Authors
- Streit, W. J., Graeber, M. B., & Kreutzberg, G. W.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 1989-08
- Volume
- 105
- Issue
- 2
- Pages
- 115-126
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2036931179
- Cited by
- 287
- References
- 2
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- green
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