The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Allopurinol and oxypurinol are hydroxyl radical scavengers
Open accessAbstract
Allopurinol is a scavenger of the highly reactive hydroxyl radical (k 2 approx. 10 9 M−1 s−1). One product of attack of hydroxyl radical upon allopurinol is oxypurinol, which is a major metabolite of allopurinol. Oxypurinol is a better hydroxyl radical scavenger than is allopurinol (k 2 approx. 4 × 10 9 M−1 s−1) and it also reacts with the myeloperoxidase‐derived oxidant hypochlorous acid. Hence the protective actions of allopurinol against reperfusion damage after hypoxia need not be entirely due to xanthine oxidase inhibition.
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Citations
Cites
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
Xanthine oxidase as a source of free radical damage in myocardial ischemia
CHAMBERS, D., PARKS, D., PATTERSON, G., ROY, R., MCCORD, J., YOSHIDA, S., PARMLEY, L., & DOWNEY, J. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80017-1 · Cited by 672
Cited by
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Self-citationHalliwell, B., Gutteridge, J. M. C., & Aruoma, O. I. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90222-3 · Cited by 2,362
Self-citationOxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856
Self-citationAntimicrobial reactive oxygen and nitrogen species: concepts and controversies
Fang, F. C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1004 · Cited by 1,676
Oxidants and human disease: some new concepts 1
Halliwell, B. (1987) · The FASEB Journal · doi:10.1096/fasebj.1.5.2824268 · Cited by 1,203
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Metadata
- Authors
- Moorhouse, P. C., Grootveld, M., Halliwell, B., Quinlan, J. G., & Gutteridge, J. M. C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1987-03-09
- Volume
- 213
- Issue
- 1
- Pages
- 23-28
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2082501904
- Cited by
- 393
- References
- 2
- FWCI
- 33.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Moorhouse, P. C., Grootveld, M., Halliwell, B., Quinlan, J. G., & Gutteridge, J. M. C. (1987). Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS Letters. https://doi.org/10.1016/0014-5793(87)81458-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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